KEGG   PATHWAY: brhi04530
Entry
brhi04530                   Pathway                                
Name
Tight junction - Buceros rhinoceros silvestris (rhinoceros hornbill)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
brhi04530  Tight junction
brhi04530

Other DBs
GO: 0005923
Organism
Buceros rhinoceros silvestris (rhinoceros hornbill) [GN:brhi]
Gene
104487925  [KO:K05692]
104488070  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
104488359  [KO:K06087]
104488399  ACTR3; actin-related protein 3 [KO:K18584]
104488425  [KO:K07374]
104488427  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104488483  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
104488602  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104488906  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
104489023  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
104489230  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
104489327  [KO:K05699]
104489472  [KO:K06087]
104489529  CLDN2; claudin-2 [KO:K06087]
104489604  [KO:K06448]
104489878  [KO:K05692]
104489945  [KO:K12755]
104490049  [KO:K07198] [EC:2.7.11.31]
104490080  CLDN16; claudin-16 [KO:K06087]
104490086  [KO:K06087]
104490090  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
104490168  CLDN10; claudin-10 [KO:K06087]
104490250  [KO:K21111]
104490313  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104490358  MICALL2; MICAL-like protein 2 [KO:K21068]
104490559  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
104490725  INADL; inaD-like protein [KO:K06092]
104490737  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104490842  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
104490850  [KO:K06099]
104491039  [KO:K07374]
104491193  TJAP1; tight junction-associated protein 1 [KO:K06105]
104491259  AMOT; angiomotin [KO:K16819]
104491427  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104491435  [KO:K05692]
104491480  PCNA; proliferating cell nuclear antigen [KO:K04802]
104491481  [KO:K06106]
104491658  [KO:K10352]
104491724  [KO:K06087]
104491910  [KO:K04392]
104492355  RDX; radixin isoform X1 [KO:K05762]
104492421  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
104492429  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
104492895  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
104492941  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
104492966  [KO:K04345] [EC:2.7.11.11]
104493031  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
104493107  CLDN1; claudin-1 [KO:K06087]
104493266  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104493288  [KO:K07374]
104493324  [KO:K06091]
104493325  JAM2; junctional adhesion molecule B [KO:K06735]
104493445  ITGB1; integrin beta-1 [KO:K05719]
104493484  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104493578  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
104493593  MLLT4; afadin [KO:K05702]
104493631  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
104493955  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
104494032  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104494170  CLDN12; claudin-12 [KO:K06087]
104494230  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
104494388  [KO:K06093]
104494408  [KO:K04392]
104494547  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
104494719  CLDN11; claudin-11 [KO:K06087]
104494849  RHOA; transforming protein RhoA [KO:K04513]
104494937  [KO:K10351]
104495021  SCRIB; protein scribble homolog [KO:K16175]
104495063  RAPGEF6; rap guanine nucleotide exchange factor 6 [KO:K08020]
104495108  [KO:K21099]
104495299  CGNL1; cingulin-like protein 1 [KO:K21110]
104495534  AMOTL2; angiomotin-like protein 2 [KO:K06104]
104495579  RAP1A; ras-related protein Rap-1A [KO:K04353]
104495861  [KO:K04440] [EC:2.7.11.24]
104495888  MSN; moesin [KO:K05763]
104496073  [KO:K16684]
104496282  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
104496449  [KO:K04382] [EC:3.1.3.16]
104496511  JAM3; junctional adhesion molecule C [KO:K06785]
104496602  [KO:K04851]
104496671  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
104496681  [KO:K06104]
104496966  CLDN18; claudin-18 isoform X1 [KO:K06087]
104497006  [KO:K04382] [EC:3.1.3.16]
104497081  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
104497099  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104497262  [KO:K04354]
104497426  [KO:K06087]
104497427  [KO:K06087]
104497474  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104497792  CLDN14; claudin-14 [KO:K06087]
104497943  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
104498020  ACTR2; actin-related protein 2 [KO:K17260]
104498038  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
104498071  MYH11; myosin-11 isoform X1 [KO:K10352]
104498175  [KO:K12757]
104498229  [KO:K13365]
104498298  [KO:K07374]
104498639  RAP2C; ras-related protein Rap-2c [KO:K07839]
104498693  [KO:K07200]
104499463  [KO:K06087]
104499645  [KO:K16684]
104499668  MPDZ; multiple PDZ domain protein [KO:K06095]
104499788  [KO:K06087]
104499893  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
104499964  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
104500038  MYH10; myosin-10 [KO:K10352]
104500448  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104500607  EZR; ezrin isoform X1 [KO:K08007]
104500703  CTTN; src substrate cortactin [KO:K06106]
104500820  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
104500957  [KO:K05757]
104501009  [KO:K07901]
104501025  CLDN23; claudin-23 [KO:K06087]
104501281  CLDN20; claudin-20 [KO:K06087]
104501301  TJP3; LOW QUALITY PROTEIN: tight junction protein ZO-3 [KO:K06097]
104501459  ACTR3B; actin-related protein 3B [KO:K18584]
104501988  [KO:K12757]
104502200  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
104502304  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104502393  [KO:K06087]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
brhi04520  Adherens junction
brhi04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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