KEGG   PATHWAY: ko04530
Entry
ko04530                     Pathway                                
Name
Tight junction
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ko04530  Tight junction
ko04530

Other DBs
GO: 0005923
Orthology
K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04237  PARD3; partitioning defective protein 3
K04345  PKA; protein kinase A [EC:2.7.11.11]
K04353  RAP1A; Ras-related protein Rap-1A
K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04393  CDC42; cell division control protein 42
K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04448  JUN; transcription factor AP-1
K04503  CCND1; G1/S-specific cyclin-D1
K04513  RHOA; Ras homolog gene family, member A
K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.39]
K04802  PCNA; proliferating cell nuclear antigen
K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
K05031  CFTR, ABCC7; cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
K05692  ACTB_G1; actin beta/gamma 1
K05699  ACTN1_4; actinin alpha 1/4
K05701  TJP1, ZO1; tight junction protein 1
K05702  AF6, MLLT4; afadin
K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K05719  ITGB1, CD29; integrin beta 1
K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
K05747  WAS; Wiskott-Aldrich syndrome protein
K05754  ARPC5; actin related protein 2/3 complex, subunit 5
K05755  ARPC4; actin related protein 2/3 complex, subunit 4
K05756  ARPC3; actin related protein 2/3 complex, subunit 3
K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758  ARPC2; actin related protein 2/3 complex, subunit 2
K05762  RDX; radixin
K05763  MSN; moesin
K06069  PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
K06087  CLDN; claudin
K06088  OCLN; occludin
K06089  F11R, JAM1, CD321; junctional adhesion molecule 1
K06090  CRB3; crumbs 3
K06091  MPP5, PALS1; MAGUK p55 subfamily member 5
K06092  INADL, PATJ; InaD-like protein
K06093  PARD6; partitioning defective protein 6
K06094  LLGL; lethal(2) giant larvae protein
K06095  MPDZ, MUPP1, Patj; multiple PDZ domain protein
K06097  TJP3, ZO3; tight junction protein 3
K06098  TJP2, ZO2; tight junction protein 2
K06099  CSDA, ZONAB; cold shock domain protein A
K06100  SYMPK; symplekin
K06102  CGN; cingulin
K06104  AMOTL; angiomotin like
K06105  TJP4, PILT; tight junction protein 4
K06106  CTTN, EMS1; cortactin
K06109  RAB13; Ras-related protein Rab-13
K06274  VASP; vasodilator-stimulated phosphoprotein
K06448  CD1; T-cell surface glycoprotein CD1
K06735  JAM2, CD322; junctional adhesion molecule 2
K06785  JAM3; junctional adhesion molecule 3
K06786  JAM4, JCAM; junctional adhesion molecule 4
K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K07298  STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K07374  TUBA; tubulin alpha
K07839  RAP2C; Ras-related protein Rap-2C
K07901  RAB8A, MEL; Ras-related protein Rab-8A
K07902  RAB8B; Ras-related protein Rab-8B
K08007  EZR, VIL2; ezrin
K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
K08367  RUNX1, AML1; runt-related transcription factor 1
K09183  GATA4; GATA-binding protein 4
K09489  HSPA4; heat shock 70kDa protein 4
K10351  MYL2; myosin regulatory light chain 2
K10352  MYH9s; myosin heavy chain 9/10/11/14
K10591  NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
K12075  DLG2; discs large protein 2
K12076  DLG1; disks large protein 1
K12751  MYL6; myosin light chain 6
K12755  MYL9; myosin regulatory light chain 9
K12757  MYL12; myosin regulatory light chain 12
K12791  ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
K13365  SLC9A3R1, NHERF1; sodium/hydrogen exchange regulatory cofactor NHE-RF1
K16175  SCRIB; protein scribble
K16684  NF2; merlin
K16819  AMOT; angiomotin
K17260  ACTR2, ARP2; actin-related protein 2
K17291  MARVELD2; MARVEL domain-containing protein 2
K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.39]
K18050  PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
K18584  ACTR3, ARP3; actin-related protein 3
K18952  PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
K20479  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules
K20638  ARHGAP17, RICH1; Rho GTPase-activating protein 17
K21066  ARHGEF18; A-kinase anchor protein 18
K21068  MICALL2, JRAB; MICAL-like protein 2
K21098  DLG3; discs large protein 3
K21099  MARVELD3; MARVEL domain-containing protein 3
K21108  BVES, POPDC1; blood vessel epicardial substance
K21109  MPP4; MAGUK p55 subfamily member 4
K21110  CGNL1; cingulin-like protein 1
K21111  EPB41L4B, EHM2, LULU2; band 4.1-like protein 4B
K21112  SYNPO; synaptopodin
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ko04520  Adherens junction
ko04810  Regulation of actin cytoskeleton

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