KEGG ORTHOLOGY: K08020

ORTHOLOGY: K08020

Entry

K08020                      KO

Symbol

RAPGEF6, PDZGEF2

Name

Rap guanine nucleotide exchange factor 6

Pathway

map04015

Rap1 signaling pathway

map04517

IgSF CAM signaling

map04530

Tight junction

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6

Genes

HSA:	51735(RAPGEF6)

PTR:	743392(RAPGEF6)

PPS:	100968786(RAPGEF6)

GGO:	101129664(RAPGEF6)

PON:	103890710(RAPGEF6)

PPYG:

129036674(RAPGEF6)

NLE:	100591273(RAPGEF6)

HMH:	116470851(RAPGEF6)

SSYN:

129493318(RAPGEF6)

MCC:	706541(RAPGEF6)

MCF:	102143429(RAPGEF6)

MTHB:

126955962

MNI:	105467197(RAPGEF6)

CSAB:

103244498(RAPGEF6)

CATY:

105599722(RAPGEF6)

PANU:

101005373(RAPGEF6)

TGE:	112625902(RAPGEF6)

MLEU:

105555476(RAPGEF6)

RRO:	104676678(RAPGEF6)

RBB:	108512577(RAPGEF6)

TFN:	117065906(RAPGEF6)

PTEH:

111529717(RAPGEF6)

CANG:

105518172(RAPGEF6)

CJC:	100386485(RAPGEF6)

SBQ:

101041774

CIMI:

108306969(RAPGEF6)

ANAN:

105713257(RAPGEF6)

CSYR:

103264106(RAPGEF6)

MMUR:

105869930(RAPGEF6)

LCAT:

123637738(RAPGEF6)

ERUF:

138392865(RAPGEF6)

PCOQ:

105821019(RAPGEF6)

OGA:	100959581(RAPGEF6)

MMU:	192786(Rapgef6)

MCAL:

110304183(Rapgef6)

MPAH:

110331568(Rapgef6)

RNO:	303141(Rapgef6)

MCOC:

116079141(Rapgef6)

ANU:	117711427(Rapgef6)

ASYL:

127693994(Rapgef6)

MMIU:

308426422(RAPGEF6)

CGE:	100763755(Rapgef6)

MAUA:

101841528(Rapgef6)

PROB:

127219278(Rapgef6)

PLEU:

114700396(Rapgef6)

PMAV:

102927137(Rapgef6)

MORG:

121456237(Rapgef6)

MFOT:

126510969

AAMP:

119811810(Rapgef6)

CNL:	130876919(Rapgef6)

HGL:	101697165(Rapgef6)

CPOC:

100733383(Rapgef6)

CCAN:

109680796(Rapgef6) 109690621

DORD:

105998948(Rapgef6)

DSP:	122115372(Rapgef6)

DMER:

138807884(Rapgef6) 138827198

PLOP:

125341885(Rapgef6)

NCAR:

124987083

SVUL:

306663646(RAPGEF6)

MMMA:

107148110(Rapgef6)

ITI:	101954382(Rapgef6)

SCIL:

308641343(RAPGEF6)

OCU:

100358155

OPI:	101535362(RAPGEF6)

OCZ:	121150189(RAPGEF6)

TUP:	102502097(RAPGEF6)

CFA:	609521(RAPGEF6)

CLUD:

112650127(RAPGEF6)

VVP:	112917094(RAPGEF6)

VLG:	121494942(RAPGEF6)

NPO:	129494521(RAPGEF6)

AML:	100482379(RAPGEF6)

UMR:	103670508(RAPGEF6)

UAH:	113261696(RAPGEF6)

UAR:	123790378(RAPGEF6)

ELK:

111140881

LLV:

125100085

MPUF:

101671556(RAPGEF6)

MNP:	132028489(RAPGEF6)

MLK:	131832007(RAPGEF6)

NVS:	122892028(RAPGEF6)

MMAQ:

308343862(RAPGEF6)

ORO:	101378373(RAPGEF6)

EJU:	114209420(RAPGEF6)

ZCA:	113928791(RAPGEF6)

MLX:	118016610(RAPGEF6)

MANO:

123840469(RAPGEF6)

NSU:	110590988(RAPGEF6)

LWW:	102734721(RAPGEF6)

FCA:	101093077(RAPGEF6)

PYU:	121010667(RAPGEF6)

PCOO:

112860319(RAPGEF6)

PBG:	122487092(RAPGEF6)

PVIV:

125173726(RAPGEF6)

LRUF:

124515394

LGF:	123603234(RAPGEF6)

AJU:

106970717

PTG:	102968394(RAPGEF6)

PPAD:

109250902(RAPGEF6)

PUC:

125934867

PLEZ:

122217452(RAPGEF6)

HHV:	120245473(RAPGEF6)

CCRU:

144235169(RAPGEF6)

BTA:	789597(RAPGEF6)

BOM:	102276794(RAPGEF6)

BIU:	109561827(RAPGEF6)

BJV:	133250965(RAPGEF6)

BBUB:

102396435(RAPGEF6)

BKE:	129628667(RAPGEF6)

BBIS:

104997593

CHX:	102191417(RAPGEF6)

OAS:	101102808(RAPGEF6)

OCAN:

138441115(RAPGEF6)

BTAX:

128051729(RAPGEF6)

CSUM:

138085262(RAPGEF6)

ODA:	120864730(RAPGEF6)

CCAD:

122440134(RAPGEF6)

MREE:

136155923(RAPGEF6)

OVR:	110141680(RAPGEF6)

MBEZ:

129558996(RAPGEF6)

SSC:	100521255(RAPGEF6)

CFR:	102524531(RAPGEF6)

CBAI:

105082091(RAPGEF6)

CDK:	105089950(RAPGEF6)

VPC:	102545333(RAPGEF6)

BACU:

103001438(RAPGEF6)

BMUS:

118892373(RAPGEF6)

LVE:	103088658(RAPGEF6)

OOR:	101284854(RAPGEF6)

LALB:

132517045(RAPGEF6)

GMF:	115860167(RAPGEF6)

DDP:	132423309(RAPGEF6)

SCOO:

307184129(RAPGEF6)

PCRS:

137221634(RAPGEF6)

DLE:	111182398(RAPGEF6)

PCAD:

102989906(RAPGEF6)

PSIU:

116750892(RAPGEF6)

PPHC:

136120076(RAPGEF6)

HAMP:

307052402(RAPGEF6)

ECB:	100063392(RAPGEF6)

EPZ:	103565155(RAPGEF6)

EAI:	106822220(RAPGEF6)

MYB:	102240423(RAPGEF6)

MYD:	102769591(RAPGEF6)

MMYO:

118657766(RAPGEF6)

MLF:	102425590(RAPGEF6)

MDT:	132235614(RAPGEF6)

MYUM:

139010512(RAPGEF6)

PKL:	118711476(RAPGEF6)

EFUS:

103287006(RAPGEF6)

POTS:

308250359(RAPGEF6)

MNA:	107525016(RAPGEF6)

DRO:	112301608(RAPGEF6)

SHON:

118990113(RAPGEF6)

AJM:	119037590(RAPGEF6)

PDIC:

114509246(RAPGEF6)

PHAS:

123808250(RAPGEF6)

MMF:	118643653(RAPGEF6)

PPAM:

129066701(RAPGEF6)

HAI:	109382579(RAPGEF6)

RFQ:	117016739(RAPGEF6)

RHII:

308491551(RAPGEF6)

PALE:

102893941(RAPGEF6)

PGIG:

120616528(RAPGEF6)

PVP:	105293536(RAPGEF6)

RAY:	107497019(RAPGEF6)

MJV:	108398447(RAPGEF6)

TOD:	119243502(RAPGEF6)

SARA:

101551303(RAPGEF6)

SFUM:

130032714(RAPGEF6)

SETR:

126027709(RAPGEF6)

LAV:	100677695(RAPGEF6)

TMU:

101359307

ETF:	101658088(RAPGEF6)

DNM:	101435609(RAPGEF6)

MDO:	100015023(RAPGEF6)

GAS:	123237633(RAPGEF6)

SHR:	100931445(RAPGEF6)

AFZ:

127549833

PCW:	110211712(RAPGEF6)

TVP:	118841438(RAPGEF6)

PBRV:

138164210(RAPGEF6)

OAA:	100079932(RAPGEF6)

TACU:

119919965(RAPGEF6)

GGA:	101751943(RAPGEF6)

PCOC:

116232225(RAPGEF6)

MGP:	100546920(RAPGEF6)

CJO:	107320073(RAPGEF6)

TPAI:

128083965(RAPGEF6)

LMUT:

125700055(RAPGEF6)

NMEL:

110405204(RAPGEF6)

APLA:

101804493(RAPGEF6)

AACU:

137864106(RAPGEF6)

OJA:	118173827(RAPGEF6)

BCLA:

308449401(RAPGEF6)

ACYG:

106032759(RAPGEF6)

ABRC:

308177751(RAPGEF6)

CATA:

118254950(RAPGEF6)

AFUL:

116494792(RAPGEF6)

TGU:	100231632(RAPGEF6)

LSR:	110481078(RAPGEF6)

VMC:	128814760(RAPGEF6)

VCHA:

128795509(RAPGEF6)

AIB:	137482988(RAPGEF6)

SCAN:

103817468(RAPGEF6)

PMOA:

120498456(RAPGEF6)

OTC:	121332453(RAPGEF6)

PRUF:

121361276(RAPGEF6)

ATRC:

139597656(RAPGEF6)

MATE:

118691933(RAPGEF6)

MAEN:

136563002(RAPGEF6)

GFR:	102036412(RAPGEF6)

FAB:	101805681(RAPGEF6)

OMA:	130258984(RAPGEF6)

PHI:	102114600(RAPGEF6)

PMAJ:

107210682(RAPGEF6)

CCAE:

111935616

CCW:	104697988(RAPGEF6)

CBRC:

103624224(RAPGEF6)

ACOE:

138117992(RAPGEF6)

ETL:	114065701(RAPGEF6)

ZAB:	102061641(RAPGEF6)

ZLE:	135453593(RAPGEF6)

ACHL:

103808766(RAPGEF6)

SVG:	106862506(RAPGEF6)

MMEA:

130585389(RAPGEF6)

LCAI:

146431174(RAPGEF6)

HRT:	120759090(RAPGEF6)

SATI:

136367420(RAPGEF6)

CFAI:

136297252(RAPGEF6)

CCIC:

134049511(RAPGEF6)

NNT:	104411726(RAPGEF6)

SHAB:

115616108(RAPGEF6)

POCC:

134173757(RAPGEF6)

PECH:

308226097(RAPGEF6)

FPG:	101919848(RAPGEF6)

FCH:	102058727(RAPGEF6)

FRS:	119152058(RAPGEF6)

CCRI:

104155623

ACUN:

113485264(RAPGEF6)

ANOC:

141964851(RAPGEF6)

SURA:

141949536(RAPGEF6)

TALA:

104365011(RAPGEF6)

ACHC:

115334303(RAPGEF6)

HALD:

104323203(RAPGEF6)

HLE:	104838847(RAPGEF6)

AGEN:

126051181

HHAR:

128155022(RAPGEF6)

BBUT:

142044168(RAPGEF6)

GCL:

127021785

CSTI:

104553575(RAPGEF6)

LDI:

104354522

MNB:	103768910(RAPGEF6)

DPUB:

104297026(RAPGEF6)

PPUS:

135185122(RAPGEF6)

IIN:	128973016(RAPGEF6)

AVIT:

104275335(RAPGEF6)

BRHI:

104495063(RAPGEF6)

EGZ:

104133480

NNI:	104012007(RAPGEF6)

PLEC:

309596298(RAPGEF6)

PCAO:

104042151(RAPGEF6)

PARX:

142061617(RAPGEF6)

PADL:

103915794(RAPGEF6)

AFOR:

103904444(RAPGEF6)

FGA:	104071287(RAPGEF6)

CBOR:

142088815(RAPGEF6)

GSTE:

104262596

CBOY:

140656449(RAPGEF6)

MAME:

142413717(RAPGEF6)

CLV:	102095625(RAPGEF6)

CNIC:

135994135(RAPGEF6)

NMAY:

308045647(RAPGEF6)

MUI:	104546169(RAPGEF6)

PGUU:

104469264

PLET:

104617012(RAPGEF6)

EHS:	104515956(RAPGEF6)

CMAC:

104482568(RAPGEF6)

CUCA:

104060646(RAPGEF6)

PCUR:

138727134(RAPGEF6)

TEO:	104374027(RAPGEF6)

BREG:

104632479(RAPGEF6)

GAME:

129212841(RAPGEF6)

OHA:	104327507(RAPGEF6)

ACAR:

104519826(RAPGEF6)

CEUR:

306721455(RAPGEF6)

CPEA:

104390363(RAPGEF6)

HEK:	139802812(RAPGEF6)

CVF:	104292040(RAPGEF6)

RTD:	128916051(RAPGEF6)

CRID:

134521878(RAPGEF6)

LMIC:

141749693(RAPGEF6)

NARQ:

141469960(RAPGEF6)

AAM:	106487219(RAPGEF6)

AROW:

112964692(RAPGEF6)

NPD:	112952415(RAPGEF6)

TGT:	104580823(RAPGEF6)

DNE:	112994082(RAPGEF6)

SCAM:

104146890(RAPGEF6)

ASN:	102387493(RAPGEF6)

AMJ:	102557740(RAPGEF6)

CPOO:

109310082(RAPGEF6)

GGN:	109289966(RAPGEF6)

PSS:	102452799(RAPGEF6)

CIZ:	142020980(RAPGEF6)

CMY:	102934455(RAPGEF6)

CCAY:

125641943(RAPGEF6)

LKP:	140915628(RAPGEF6)

NDS:	141991970(RAPGEF6)

DCC:	119860282(RAPGEF6)

CPIC:

101941486(RAPGEF6)

TST:	117881301(RAPGEF6)

EOB:	135883069(RAPGEF6)

CABI:

116818329(RAPGEF6)

MRV:	120370829(RAPGEF6)

EMQ:	137165308(RAPGEF6)

ACS:	100553829(rapgef6)

ASAO:

132768877

PVT:

110079410

SUND:

121921337(RAPGEF6)

PBI:	103064011(RAPGEF6)

PMUR:

107285994

CTIG:

120299782(RAPGEF6)

PGUT:

117656157(RAPGEF6)

PCAE:

139312482(RAPGEF6)

APRI:

131190944(RAPGEF6)

PTEX:

113433740(RAPGEF6)

NSS:	113425279(RAPGEF6)

VKO:	123035859(RAPGEF6)

PMUA:

114589738 114591262(RAPGEF6)

PRAF:

128407862(RAPGEF6)

ZVI:	118080351(RAPGEF6)

HCG:	128346939(RAPGEF6)

GJA:	107126038(RAPGEF6)

STOW:

125428432(RAPGEF6)

EMC:	129329441(RAPGEF6)

XLA:

108712621

XTR:	733941(rapgef6)

PWL:	138246955(RAPGEF6)

MUO:	115475536 115476372

GSH:	117351553(RAPGEF6) 117368553

DRE:	335032(rapgef6)

DAES:

130215122

SRX:	107739208 107742454

SANH:

107661689 107692966

SGH:	107566248 107603232

CCAR:

CAUA:

CGIB:

PTET:

LROH:

127152237(rapgef6)

GRF:	141292697(rapgef6)

OMC:	131528492(rapgef6)

PPRM:

120473664(rapgef6)

RKG:	130077512(rapgef6)

SCEP:

307144609(rapgef6)

PPHX:

306984046(rapgef6)

MAMB:

125253081(rapgef6)

CIDE:

127503338

CERY:

137012350(rapgef6)

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:	108278772(rapgef6)

IFU:	128622296(rapgef6)

PHYP:

113543032(rapgef6)

SMEO:

124397617(rapgef6)

TFD:	113638599(rapgef6)

TVC:	132859531(rapgef6)

CGAR:

128507369(rapgef6)

NGRA:

132895342(rapgef6)

TRN:	134330944(rapgef6)

AMEX:

103043076

CMAO:

118819951

EEE:

113578024

CHAR:

105896482(rapgef6)

SPIL:

134079908(rapgef6)

ASAD:

121710008(rapgef6)

TRU:	101075836(rapgef6)

TFS:	130538112(rapgef6)

TNG:	GSTEN00029876G001

NCC:	104943230(rapgef6)

TBEN:

117490291(rapgef6)

CGOB:

115018866

PGEO:

117458269

GACU:

117540088(rapgef6)

EMAC:

134871922(rapgef6)

ELY:	117266287(rapgef6)

EFO:	125898924(rapgef6)

PLEP:

121953064(rapgef6)

SLUC:

116056046(rapgef6)

SVIT:

144527304(rapgef6)

ECRA:

117955975(rapgef6)

ESP:

116699986

PFLV:

114566755(rapgef6)

PFLT:

120544317(rapgef6)

GAT:	120821657(rapgef6)

PPUG:

119215883(rapgef6)

AFB:	129113108(rapgef6)

CLUM:

117742415(rapgef6)

PSWI:

130191762

CANA:

137802506(rapgef6)

CVE:	137890798(rapgef6)

AMIR:

142960193(rapgef6)

MSAM:

119894871(rapgef6)

SCHU:

122888738

EARM:

139294791(rapgef6)

CUD:

121518508

SPUL:

138597864

LMIX:

132988017

HTC:	141791857(rapgef6)

ALAT:

119031093

ASTR:

137605804

PKLU:

139213416

LCO:	104921050(rapgef6)

AMMM:

307260249(rapgef6)

MZE:	101467019(rapgef6)

ONL:

100709723

OAU:

116315770

OLA:	101165993(rapgef6)

OML:	112142896(rapgef6)

CSAI:

133460030

XMA:	102224759(rapgef6)

XCO:	114153362(rapgef6)

XHE:	116727880(rapgef6)

PRET:

103475327(rapgef6)

PFOR:

103152198(rapgef6)

PLAI:

106950546

PMEI:

106909961

GAF:

122844678

PPRL:

129373445(rapgef6)

CVG:

107104672

CTUL:

119797649

GMU:	124876401(rapgef6)

NFU:

107386829

KMR:	108238065(rapgef6)

ALIM:

106533947

NWH:

119420836

LTU:

140279964

TBT:	306761637(rapgef6)

MCEP:

125021027(rapgef6)

AOCE:

111583549(rapgef6)

EJA:	138213665(rapgef6)

BFRE:

138631948

LCF:

108893518

CSEM:

103394770(rapgef6)

POV:	109628648(rapgef6)

SSEN:

122780159(rapgef6)

SSOE:

131458146

HHIP:

117774939(rapgef6)

HSP:	118121785(rapgef6)

PPLT:

128457357(rapgef6)

SMAU:

118300945(rapgef6)

SDU:

111234286

SLAL:

111657380(rapgef6)

XGL:	120802218(rapgef6)

HCQ:	109515650(rapgef6)

SSCV:

125981879(rapgef6)

SBIA:

133492020(rapgef6)

PEE:	133415811(rapgef6)

PTAO:

133467530(rapgef6)

BPEC:

110169267

ENY:	140360719(rapgef6)

MALB:

109966822

BSPL:

114869799(rapgef6)

SJO:

128371915

SSCO:

133994187

TTY:	137195882(rapgef6)

GMH:	115547566(rapgef6)

ZFA:	307240612(rapgef6)

SASA:

106567521 106603825

STRU:

115148552 115154016(rapgef6)

OTW:	112228329 112258100

OMY:	110533377 110537734(rapgef6)

OGO:	123999125 124013748

ONE:	115105278 115136189

OKI:	109872506 109892955

OKE:	118390645 118390890

OMM:

135548828

OCLA:

139418034 139420789

SALP:

111950476 111981742

SNH:	120032004 120056867

SFON:

129820886 129868197

CCLU:

121574010 121580109

ELS:	105028267(rapgef6)

OEP:	134013617(rapgef6)

SFM:	108929682 108934339(rapgef6)

PKI:	111839518 111847952

AANG:

118235678(rapgef6)

AROT:

135262683(rapgef6)

CCOG:

133132323(rapgef6)

LOC:	102691203(rapgef6)

PSPA:

121296772 121324193

ARUT:

117431624 117964607

PSEX:

120542797(rapgef6)

LCM:	102351728(RAPGEF6)

CMK:	103183673(rapgef6)

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

CLEP:

PMEO:

XEN:

Reference

PMID:10934204

Authors

Rebhun JF, Castro AF, Quilliam LA

Title

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.

Journal

J Biol Chem 275:34901-8 (2000)
DOI:10.1074/jbc.M005327200

Reference

PMID:12581858

Authors

Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ

Title

Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.

Journal

Biochim Biophys Acta 1593:141-9 (2003)
DOI:10.1016/S0167-4889(02)00365-8

Sequence

[hsa:51735]

LinkDB

DBGET integrated database retrieval system