KEGG ORTHOLOGY: K06098

ORTHOLOGY: K06098

Entry

K06098                      KO

Symbol

TJP2, ZO2

Name

tight junction protein 2

Pathway

map04517

IgSF CAM signaling

map04530

Tight junction

map05110

Vibrio cholerae infection

Disease

H00624

Progressive familial intrahepatic cholestasis

H01935

Familial hypercholanemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    K06098  TJP2, ZO2; tight junction protein 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K06098  TJP2, ZO2; tight junction protein 2
09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K06098  TJP2, ZO2; tight junction protein 2

Genes

HSA:	9414(TJP2)

PTR:	464514(TJP2)

PPS:	100980690(TJP2)

GGO:	101152430(TJP2)

PON:	100434798(TJP2)

PPYG:

129044035(TJP2)

NLE:

100579261

HMH:	116475132(TJP2)

SSYN:

129479344(TJP2)

MCC:	699586(TJP2)

MCF:	102121551(TJP2)

MTHB:

126937643

MNI:	105491857(TJP2)

CSAB:

103219551(TJP2)

CATY:

105584149(TJP2)

PANU:

101027000(TJP2)

TGE:	112607823(TJP2)

MLEU:

105532093(TJP2)

RRO:	104662059(TJP2)

RBB:	108530271(TJP2)

TFN:	117098495(TJP2)

PTEH:

111543335(TJP2)

CANG:

105516644(TJP2)

CJC:	100391042(TJP2)

SBQ:	101032876(TJP2)

CIMI:

108314514(TJP2)

ANAN:

105718101(TJP2)

CSYR:

103268478(TJP2)

MMUR:

105855751(TJP2)

LCAT:

123645886(TJP2)

ERUF:

138388367(TJP2)

PCOQ:

105808056(TJP2)

OGA:	100958865(TJP2)

MMU:	21873(Tjp2)

MCAL:

110285404(Tjp2)

MPAH:

110316246(Tjp2)

RNO:	115769(Tjp2)

MCOC:

116103675(Tjp2)

ANU:	117710400(Tjp2)

ASYL:

127688902(Tjp2)

MUN:	110555636(Tjp2)

CGE:

107976993

MAUA:

101837639(Tjp2)

PROB:

127233597(Tjp2)

PLEU:

114710013(Tjp2)

PMAV:

102911077(Tjp2)

MORG:

121453838(Tjp2)

MFOT:

126511611

AAMP:

119823437(Tjp2)

CNL:	130879416(Tjp2)

NGI:	103732322(Tjp2)

HGL:	101722709(Tjp2)

CPOC:

100729549(Tjp2)

CCAN:

109696411(Tjp2)

DORD:

105987257(Tjp2)

DSP:	122124657(Tjp2)

DMER:

138836980(Tjp2)

PLOP:

125340932(Tjp2)

NCAR:

124964368

MMMA:

107148201(Tjp2)

ITI:	101974548(Tjp2)

OCU:

100356517

OPI:	101528076(TJP2)

OCZ:	121155732(TJP2)

TUP:	102482678(TJP2)

GVR:	103589722(TJP2)

CFA:	403854(TJP2)

CLUD:

112644752(TJP2)

VVP:	112922121(TJP2)

VLG:	121482494(TJP2)

NPO:	129500844(TJP2)

AML:	100483240(TJP2)

UMR:	103663337(TJP2)

UAH:	113270199(TJP2)

UAR:	123776549(TJP2)

ELK:

111153615

LLV:

125082899

MPUF:

101690058(TJP2)

MNP:	132024832(TJP2)

MLK:	131812388(TJP2)

NVS:	122917717(TJP2)

ORO:	101372161(TJP2)

EJU:	114219763(TJP2)

ZCA:	113934445(TJP2)

MLX:	118026316(TJP2)

MANO:

123849539(TJP2)

NSU:	110584314(TJP2)

LWW:	102749747(TJP2)

FCA:	101081681(TJP2)

PYU:	121013660(TJP2)

PCOO:

112868738(TJP2)

PBG:	122474785(TJP2)

PVIV:

125150399(TJP2)

LRUF:

124528284

LGF:	123593488(TJP2)

AJU:

106985799

PTG:	102958432(TJP2)

PPAD:

109275434(TJP2)

PUC:

125924800

PLEZ:

122204447(TJP2)

HHV:	120243405(TJP2)

CCRU:

144227697(TJP2)

BTA:	407101(TJP2)

BOM:	102272665(TJP2)

BIU:	109562940(TJP2)

BBUB:

102399740(TJP2)

BKE:	129650084(TJP2)

BBIS:

105003472(TJP2)

CHX:	102180039(TJP2)

OAS:	443506(TJP2)

BTAX:

128052807(TJP2)

CSUM:

138081064(TJP2)

ODA:	120869962(TJP2) 120879849

CCAD:

122453223(TJP2)

MREE:

136148595(TJP2)

OVR:	110149475(TJP2)

MBEZ:

129557631(TJP2)

SSC:	100513065(TJP2)

CFR:	102524480(TJP2)

CBAI:

105079197

CDK:	105105915(TJP2)

VPC:	102536009(TJP2)

BACU:

103000660(TJP2)

BMUS:

118897167(TJP2)

LVE:	103085467(TJP2)

OOR:	101277846(TJP2)

LALB:

132523604(TJP2)

GMF:	115863836(TJP2)

DDP:	132427315(TJP2)

DLE:	111174618(TJP2)

PCAD:

102996306(TJP2)

PSIU:

116755638(TJP2)

PPHC:

136124084(TJP2)

NASI:

112392536(TJP2)

ECB:	100050442(TJP2)

EPZ:	103558793(TJP2)

EAI:	106834379(TJP2)

MYB:	102256901(TJP2)

MYD:	102753978(TJP2)

MMYO:

118667477(TJP2)

MLF:	102440160(TJP2)

MDT:	132211968(TJP2)

MYUM:

139021207(TJP2)

PKL:	118716511(TJP2)

EFUS:

103286543(TJP2)

MNA:	107538123(TJP2)

DRO:	112299985(TJP2)

SHON:

118997833(TJP2)

AJM:	119058423(TJP2)

PDIC:

114494386(TJP2)

PHAS:

123819768(TJP2)

MMF:	118629764(TJP2)

PPAM:

129078275(TJP2)

HAI:	109392535(TJP2)

RFQ:	117031914(TJP2)

PALE:

102888108(TJP2)

PGIG:

120581125(TJP2)

PVP:	105307130(TJP2)

RAY:	107505401(TJP2)

MJV:	108396272(TJP2)

TOD:	119232851(TJP2)

SARA:

101545004(TJP2)

SFUM:

130016210(TJP2)

SETR:

126004516(TJP2)

LAV:	100665016(TJP2)

TMU:

101349444

ETF:	101653285(TJP2)

DNM:	101435840(TJP2)

MDO:	100021752(TJP2)

GAS:	123233224(TJP2)

SHR:	100925154(TJP2)

AFZ:

127538185

PCW:	110218832(TJP2)

TVP:	118830835(TJP2)

PBRV:

138160307(TJP2)

MLAO:

141496873(TJP2)

OAA:	100074094(TJP2)

TACU:

119947802(TJP2)

GGA:	395751(TJP2)

PCOC:

116238869(TJP2)

MGP:	100540971(TJP2)

CJO:	107306172(TJP2)

TPAI:

128089366(TJP2)

LMUT:

125686818(TJP2)

NMEL:

110389445(TJP2)

APLA:

101798664(TJP2)

AACU:

137848444(TJP2)

OJA:	118155970(TJP2)

ACYG:

106044149(TJP2)

CATA:

118253769(TJP2)

AFUL:

116500466(TJP2)

TGU:	100229218(TJP2)

LSR:	110470674(TJP2)

SCAN:

103819441(TJP2)

PMOA:

120511931(TJP2)

OTC:	121333052(TJP2)

PRUF:

121363327(TJP2)

ATRC:

139588994(TJP2)

GFR:	102042064(TJP2)

FAB:	101807165(TJP2)

OMA:	130264768(TJP2)

PHI:	102104576(TJP2)

PMAJ:

107216229(TJP2)

CCAE:

111940611(TJP2)

CCW:	104685213(TJP2)

CBRC:

103613120(TJP2)

ACOE:

138103772(TJP2)

ETL:	114056560(TJP2)

ZAB:	102073763(TJP2)

ZLE:	135460069(TJP2)

ACHL:

103810614(TJP2)

SVG:	106848944(TJP2)

MMEA:

130573239(TJP2)

HRT:	120765110(TJP2)

SATI:

136374032(TJP2)

CFAI:

136288059(TJP2)

CCIC:

134057055(TJP2)

FPG:	101913859(TJP2)

FCH:	102057931(TJP2)

NNT:	104412697(TJP2)

SHAB:

115619636(TJP2)

ACUN:

113489968(TJP2)

ANOC:

141973434(TJP2)

SURA:

141938377(TJP2)

TALA:

104362999(TJP2)

ACHC:

115336471(TJP2)

HALD:

104317330(TJP2)

HLE:	104832417(TJP2)

AGEN:

126035805

HHAR:

128136299(TJP2)

BBUT:

142027227(TJP2)

GCL:

127027223

CSTI:

104550105(TJP2)

LDI:	104354557(TJP2)

MNB:	103774793(TJP2)

DPUB:

104305720(TJP2)

PPUS:

135173458(TJP2)

AVIT:

104267695(TJP2)

BRHI:

104498038(TJP2)

EGZ:	104123835(TJP2)

NNI:	104008675(TJP2)

PCRI:

104037463(TJP2)

PCAO:

104050312(TJP2)

PARX:

142050368(TJP2)

PADL:

103920368(TJP2)

AFOR:

103903967(TJP2)

FGA:	104082769(TJP2)

CBOR:

142075863(TJP2)

GSTE:

104250756(TJP2)

CBOY:

140650529(TJP2)

MAME:

142421535(TJP2)

CLV:	102093643(TJP2)

CNIC:

136002627(TJP2)

MUI:	104544109(TJP2)

PGUU:

104458514(TJP2)

PLET:

104627493(TJP2)

EHS:	104517088(TJP2)

CMAC:

104482635(TJP2)

CUCA:

104063166(TJP2)

TEO:	104380930(TJP2)

BREG:

104635720(TJP2)

GAME:

129199802(TJP2)

OHA:	104338851(TJP2)

ACAR:

104518087(TJP2)

CPEA:

104398337(TJP2)

CVF:	104288840(TJP2)

RTD:	128902532(TJP2)

CRID:

134508791(TJP2)

LMIC:

141736571(TJP2)

NARQ:

141476846(TJP2)

AAM:	106484412(TJP2)

AROW:

112969848(TJP2)

NPD:	112944390(TJP2)

TGT:	104578800(TJP2)

DNE:	112981835(TJP2)

SCAM:

104142232(TJP2)

ASN:	102368197(TJP2)

AMJ:	102558026(TJP2)

CPOO:

109323494(TJP2)

GGN:	109297608(TJP2)

PSS:	102458582(TJP2)

CIZ:	142013437(TJP2)

CMY:	102946647(TJP2)

CCAY:

125637357(TJP2)

LKP:	140911673(TJP2)

NDS:	141987686(TJP2)

DCC:	119855955(TJP2)

CPIC:

101940289(TJP2)

TST:	117878832(TJP2)

CABI:

116837457(TJP2)

MRV:	120407589(TJP2)

ACS:	100564171(tjp2)

ASAO:

132767367(TJP2)

PVT:	110085446(TJP2)

SUND:

121920192(TJP2)

PBI:	103065428(TJP2)

PMUR:

107294422(TJP2)

CTIG:

120314368(TJP2)

TSR:

106537964

PGUT:

117661462(TJP2)

PCAE:

139313187(TJP2)

APRI:

131191015(TJP2)

PTEX:

113438427(TJP2)

NSS:	113417190(TJP2)

VKO:	123031181(TJP2)

PMUA:

114606272(TJP2)

PRAF:

128423539(TJP2)

ZVI:	118076722(TJP2)

HCG:	128345199(TJP2)

GJA:	107105861(TJP2)

STOW:

125436282(TJP2)

EMC:	129334364(TJP2)

XLA:	108706964 108714442

XTR:	733995(tjp2)

NPR:

108786370

RTEM:

120943508(TJP2)

ACAT:

141147437(TJP2)

PADS:

140326003(TJP2)

BBUF:

120989172(TJP2)

BGAR:

122922236

DTC:	141086291(TJP2)

PWL:

138287834

MUO:

115463388

GSH:	117350495(TJP2)

DRE:	436639(tjp2b) 565446(tjp2a)

SRX:	107725288(tjp2) 107726556 107743118 107757293

SANH:

107664975 107667254 107705046

SGH:	107548649 107558666 107566802 107598973

CCAR:

109060867 109091978(tjp2a) 109094839 109107960

CAUA:

113054174 113071759 113076073 113107158 113109628

CGIB:

127963294 127966290 128018913 128021505

PTET:

122349970 122352725(tjp2a)

LROH:

127169888 127171900(tjp2a)

GRF:	141298732(tjp2a)

OMC:	131545237 131548503(tjp2a)

PPRM:

120474578 120482801(tjp2a)

RKG:	130076577(tjp2a) 130091692

MAMB:

125257999(tjp2a) 125280607

CIDE:

127517995 127520920

CERY:

137026891 137028898(tjp2a)

MASI:

127414706 127423942 127432329 127433766

TROS:

130546047(tjp2a) 130567618

TDW:	130407018 130411812(tjp2a)

MANU:

129414914(tjp2b) 129447374(tjp2a)

PDAB:

135730420(tjp2b) 135779512(tjp2a)

IPU:	108265610 108276877(tjp2a)

IFU:	128608109 128620827(tjp2a)

PHYP:

113525336 113535329(tjp2)

SMEO:

124393764(tjp2a) 124400410

TFD:	113634327 113653038(tjp2a)

TVC:	132853898 132863738(tjp2a)

CGAR:

128529788 128545630(tjp2a)

NGRA:

132873494(tjp2a) 132893319

TRN:	134318276 134332695(tjp2a)

AMEX:

103035951 103041684(tjp2a)

CMAO:

118813840 118824390(tjp2a)

EEE:	113575593(tjp2) 113580041

CHAR:

105901228 105910442(tjp2a)

SPIL:

134071116(tjp2a) 134089066

ASAD:

121698388(tjp2a) 121715367

TRU:	101076035 101077970

TFS:	130517030(tjp2a) 130526544

TNG:	GSTEN00005611G001 GSTEN00007214G001

LCO:	104922894(tjp2) 104938752

NCC:	104956084 104966282

TBEN:

117472801

CGOB:

115012998(tjp2) 115016644

PGEO:

117452158 117456023(tjp2a)

GACU:

117534963

EMAC:

134868161(tjp2a) 134873755

ELY:	117252934 117269601(tjp2a)

EFO:	125890941 125905779(tjp2a)

PLEP:

121944260 121959680

SLUC:

116034727(tjp2a) 116050419

ECRA:

117944221 117958834(tjp2a)

ESP:	116689879 116703858

PFLV:

114555715(tjp2) 114571539

GAT:	120831494(tjp2a)

PPUG:

119226932(tjp2a)

AFB:	129100842 129102126(tjp2a)

CLUM:

117737011 117740563(tjp2a)

PSWI:

130196518 130205216(tjp2a)

CANA:

137784313(tjp2a) 137799442(tjp2b)

CVE:	137867579(tjp2b) 137888919(tjp2a)

MSAM:

119891217 119914138(tjp2a)

SCHU:

122865255(tjp2a) 122876891

EARM:

139283638(tjp2b) 139301355(tjp2a)

CUD:	121509480 121525008(tjp2a)

SPUL:

138605073(tjp2a)

LMIX:

132973855 132992293(tjp2a)

HTC:	141789971(tjp2b) 141805330(tjp2a)

ALAT:

119019399 119029549(tjp2a)

ASTR:

137592065(tjp2b) 137609003(tjp2a)

PKLU:

139204373 139218502(tjp2a)

MZE:	101484906(tjp2)

ONL:	100698552(tjp2)

OAU:	116324933(tjp2a)

OLA:	101160994(tjp2)

OML:	112162858(tjp2a)

CSAI:

133455445(tjp2a)

XMA:	102225919(tjp2)

XCO:	114149755(tjp2)

XHE:	116724439(tjp2)

PRET:

103474079(tjp2)

PFOR:

103154529(tjp2)

PLAI:

106935284(tjp2)

PMEI:

106907519(tjp2)

GAF:	122846985(tjp2a)

PPRL:

129366443 129379623

CVG:	107083750(tjp2)

CTUL:

119785161(tjp2a)

GMU:	124872300(tjp2a)

NFU:	107375108(tjp2)

KMR:	108245760(tjp2a)

ALIM:

106527648(tjp2)

NWH:	119425125(tjp2a)

AOCE:

111576573(tjp2a) 111579322

EJA:	138192119 138205257(tjp2a)

BFRE:

138625161(tjp2a) 138635897(tjp2b)

MCEP:

124996330(tjp2a) 125011573

CSEM:

103389036 103397371(tjp2)

POV:	109640903(tjp2)

SSEN:

122758055(tjp2a) 122768948

SSOE:

131446525(tjp2a) 131463654

HHIP:

117771510(tjp2a)

HSP:	118125652(tjp2a)

PPLT:

128425399(tjp2a)

SMAU:

118285161(tjp2a)

LCF:	108878401 108889024(tjp2a)

SDU:	111221140 111230442

SLAL:

111647998 111650149

XGL:	120805729 120806223(tjp2a)

HCQ:	109527058(tjp2)

SSCV:

125979796(tjp2a)

SBIA:

133490478(tjp2a)

PEE:	133413343(tjp2a)

PTAO:

133465311(tjp2a)

BPEC:

110159939 110172482

ENY:	140346978 140367083(tjp2a)

MALB:

109968671(tjp2)

BSPL:

114846296 114866597(tjp2a)

SJO:	128365276 128380713(tjp2a)

SSCO:

133978998 133995001(tjp2a)

TTY:	137170302(tjp2a) 137190649

GMH:	115542921 115545965

SASA:

106563322 106566671 106570821 106584891

STRU:

115159600 115164101 115200536(tjp2) 115204038

OTW:	112220400 112230958 112236937 112249540

OMY:	110509763(tjp2a) 110523554 110526042 110536406

OGO:	124007126(tjp2a) 124034022 124036610 124048993

ONE:	115101138 115111933 115122316

OKI:	109867945 109873698 109883845 109894960

OKE:	118377180 118385333 118387504 118393557

OMM:	135513769 135518013 135545638

OCLA:

139388548 139390107 139408607 139411209

SALP:

111961646 111963992 111974580

SNH:	120021726 120025718 120044002 120063471

SFON:

129818416 129826640 129853912 129863900

CCLU:

121530716 121541644 121582523 121585174

ELS:	105014079(tjp2) 105015054

OEP:	134015040 134034069(tjp2a)

SFM:	108927871 108938992(tjp2)

PKI:	111839431(tjp2) 111851482

AANG:

118212944(tjp2a) 118237445

AROT:

135233391 135238852(tjp2a)

CCOG:

133139925 133142084(tjp2a)

LOC:	102686926(tjp2)

PSPA:

121303167 121314858

ARUT:

117411683 117962644

PSEX:

120527394(tjp2a)

LCM:	102353558(TJP2)

CMK:	103178109(tjp2a)

RTP:

109910664

CPLA:

122563218(tjp2a)

CPUN:

140489170(tjp2a)

HOC:	132824859(tjp2a)

SCAU:

119970602

LERI:

129695515(tjp2a)

HAKA:

140729103(tjp2a)

BBEL:

CLEP:

HSY:

Reference

PMID:10026224

Authors

Itoh M, Morita K, Tsukita S

Title

Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.

Journal

J Biol Chem 274:5981-6 (1999)
DOI:10.1074/jbc.274.9.5981

Sequence

[mmu:21873]

LinkDB

DBGET integrated database retrieval system