KEGG   PATHWAY: bspl00983
Entry
bspl00983                   Pathway                                
Name
Drug metabolism - other enzymes - Betta splendens (Siamese fighting fish)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
bspl00983  Drug metabolism - other enzymes
bspl00983

Organism
Betta splendens (Siamese fighting fish) [GN:bspl]
Gene
114856879  hprt1l; hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
114864238  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
114859215  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
114862121  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
114857394  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
114868340  gmps; GMP synthase [glutamine-hydrolyzing] isoform X2 [KO:K01951] [EC:6.3.5.2]
114866306  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
114851026  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
114853426  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
114856899  ces2b; neuroligin-3 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
114844363  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
114844364  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114861779  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
114852093  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114852095  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
114845114  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
114867122  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
114853744  UDP-glucuronosyltransferase 1-6-like isoform X2 [KO:K00699] [EC:2.4.1.17]
114847114  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
114869064  UDP-glucuronosyltransferase 1A5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
114869065  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
114869066  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
114869067  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
114869068  UDP-glucuronosyltransferase 1A5-like isoform X2 [KO:K00699] [EC:2.4.1.17]
114862689  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
114862693  UDP-glucuronosyltransferase 2A1-like isoform X4 [KO:K00699] [EC:2.4.1.17]
114862692  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
114845622  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
114844066  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
114861778  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
114869074  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
114855389  cdab; cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
114850449  zgc:103586 [KO:K01489] [EC:3.5.4.5]
114862527  tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
114844095  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
114843638  dpys; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
114862565  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
114843740  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
114847400  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
114844021  uck2b; uridine-cytidine kinase 2-B isoform X1 [KO:K00876] [EC:2.7.1.48]
114858503  uckl1a; uridine-cytidine kinase-like 1a isoform X1 [KO:K00876] [EC:2.7.1.48]
114858760  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
114866489  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
114849375  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
114856264  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
114870464  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
114847700  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
114844858  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
114868225  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
114869905  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
114865501  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
114850000  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
114845292  nucleoside diphosphate kinase A2-like [KO:K00940] [EC:2.7.4.6]
114859953  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
114860847  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
114854713  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
114861025  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
114849940  nme6; nucleoside diphosphate kinase 6 isoform X2 [KO:K00940] [EC:2.7.4.6]
114842858  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
114852283  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
121201626  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
114852644  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
114841779  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
114842190  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
114844053  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
114852066  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
114865586  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
114865874  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
114865875  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
114859447  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
114861443  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
114861595  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
114848191  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
114861877  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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