KEGG   PATHWAY: bur00260
Entry
bur00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia lata
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bur00260  Glycine, serine and threonine metabolism
bur00260

Module
bur_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bur00260]
bur_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bur00260]
bur_M00555  Betaine biosynthesis, choline => betaine [PATH:bur00260]
bur_M00621  Glycine cleavage system [PATH:bur00260]
bur_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bur00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia lata [GN:bur]
Gene
Bcep18194_A5380  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Bcep18194_B2130  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Bcep18194_A5155  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Bcep18194_B2229  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Bcep18194_A5154  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
Bcep18194_B0178  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Bcep18194_B2754  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bcep18194_B0571  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bcep18194_A3895  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bcep18194_B3022  Aminotransferase, class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Bcep18194_A4851  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
Bcep18194_A6308  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bcep18194_A5027  Gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Bcep18194_A4216  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Bcep18194_A5226  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Bcep18194_A6186  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Bcep18194_A3771  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Bcep18194_B0965  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bcep18194_B1312  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bcep18194_A6483  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bcep18194_A4155  phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
Bcep18194_A5077  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Bcep18194_A3894  Short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
Bcep18194_A4993  Glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
Bcep18194_B3179  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Bcep18194_B3178  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Bcep18194_C6829  Amine oxidase [KO:K00274] [EC:1.4.3.4]
Bcep18194_C6833  Amine oxidase [KO:K00274] [EC:1.4.3.4]
Bcep18194_A3323  Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
Bcep18194_A3325  Glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Bcep18194_A5441  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bcep18194_A4651  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bcep18194_A4363  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bcep18194_A3324  Glycine cleavage H-protein [KO:K02437]
Bcep18194_A5588  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Bcep18194_B0530  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Bcep18194_B0553  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Bcep18194_C6720  Betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bcep18194_B3062  Aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bcep18194_B2788  Betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bcep18194_B0535  aldehyde dehydrogenase (acceptor) [KO:K00130] [EC:1.2.1.8]
Bcep18194_B0554  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bcep18194_A4372  Aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bcep18194_B0578  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
Bcep18194_B0579  Ferredoxin/Oxidoreductase [KO:K21832] [EC:1.14.13.251]
Bcep18194_B0574  NADH-flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
Bcep18194_B0575  conserved hypothetical protein [KO:K21834]
Bcep18194_B0576  Electron transfer flavoprotein, alpha subunit [KO:K25960]
Bcep18194_B0577  Electron transfer flavoprotein beta-subunit [KO:K25961]
Bcep18194_B0488  Sarcosine oxidase, alpha subunit, heterotetrameric [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Bcep18194_B0486  Sarcosine oxidase, beta subunit, heterotetrameric [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Bcep18194_B0489  Sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Bcep18194_B0487  Sarcosine oxidase, delta subunit, heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Bcep18194_A3321  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Bcep18194_B0485  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Bcep18194_A6064  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Bcep18194_A5257  Pyridoxal-5'-phosphate-dependent enzyme, beta subunit [KO:K01754] [EC:4.3.1.19]
Bcep18194_A4400  L-serine ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
Bcep18194_B1364  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
Bcep18194_A6070  amino acid aldolase or racemase-like protein [KO:K01753] [EC:4.3.1.18]
Bcep18194_A5449  Aspartate racemase [KO:K25316] [EC:5.1.1.10]
Bcep18194_B2123  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Bcep18194_B2125  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bur00010  Glycolysis / Gluconeogenesis
bur00020  Citrate cycle (TCA cycle)
bur00230  Purine metabolism
bur00250  Alanine, aspartate and glutamate metabolism
bur00270  Cysteine and methionine metabolism
bur00290  Valine, leucine and isoleucine biosynthesis
bur00300  Lysine biosynthesis
bur00330  Arginine and proline metabolism
bur00460  Cyanoamino acid metabolism
bur00470  D-Amino acid metabolism
bur00564  Glycerophospholipid metabolism
bur00600  Sphingolipid metabolism
bur00620  Pyruvate metabolism
bur00630  Glyoxylate and dicarboxylate metabolism
bur00640  Propanoate metabolism
bur00680  Methane metabolism
bur00860  Porphyrin metabolism
bur00920  Sulfur metabolism
KO pathway
ko00260   
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