KEGG   PATHWAY: ccar00983
Entry
ccar00983                   Pathway                                
Name
Drug metabolism - other enzymes - Cyprinus carpio (common carp)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ccar00983  Drug metabolism - other enzymes
ccar00983

Organism
Cyprinus carpio (common carp) [GN:ccar]
Gene
109049634  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
109049648  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
109102120  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
109102125  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
109090039  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
109071337  inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
109055258  inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
109112271  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
109094871  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
109109579  LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
109110637  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
109071417  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
109068140  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
109107555  xdh; LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109084316  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109046889  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
109083978  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
109064551  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109056541  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109057107  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109110275  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
109053015  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
109057111  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
109059962  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109109202  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109049143  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109071122  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
109082610  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
109098443  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109084993  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
109063598  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109080734  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
109080736  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109081914  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
109081915  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
109109910  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109076911  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
109096697  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
109105788  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109098390  UDP-glucuronosyltransferase 2B20-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109081528  LOW QUALITY PROTEIN: beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
109081530  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
109094498  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
109078535  LOW QUALITY PROTEIN: dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
109053453  dihydropyrimidinase-related protein 2-like [KO:K01464] [EC:3.5.2.2]
109108749  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
109067608  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
109063196  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
109079176  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
109078224  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
109096464  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
109048804  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
109056160  uridine-cytidine kinase 2-B isoform X1 [KO:K00876] [EC:2.7.1.48]
109053767  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
109056415  uridine-cytidine kinase 2-B-like [KO:K00876] [EC:2.7.1.48]
109059530  uridine-cytidine kinase 1-like [KO:K00876] [EC:2.7.1.48]
109083859  uridine-cytidine kinase 1-like [KO:K00876] [EC:2.7.1.48]
109065232  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
109094876  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
109104868  uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
109094812  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
109070125  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
109106621  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
109092739  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
109048762  LOW QUALITY PROTEIN: thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
109086856  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
109091079  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
109097006  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
109098920  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
109055366  adenylate kinase isoenzyme 1-like [KO:K13800] [EC:2.7.4.14]
109106488  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
109100240  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
109112777  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
109113563  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
109075069  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
109060558  LOW QUALITY PROTEIN: nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
109049405  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
109056520  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
109044822  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
109079280  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
109050885  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
109052065  eosinophil peroxidase-like [KO:K10789] [EC:1.11.2.2]
109052003  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
109093152  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
109098442  arylamine N-acetyltransferase, pineal gland isozyme NAT-3-like [KO:K00622] [EC:2.3.1.5]
109108745  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109100494  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
109091362  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109091363  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109102997  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
109049692  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109049693  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109049695  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109051860  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109051867  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109048730  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109046037  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109100689  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109094460  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
109075623  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109075659  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109103891  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109087083  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
109087090  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
109101378  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109068262  mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
109094598  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
109102495  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
109090487  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
109090485  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system