KEGG   PATHWAY: ccrc04141
Entry
ccrc04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Colias croceus (clouded yellow)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ccrc04141  Protein processing in endoplasmic reticulum
ccrc04141

Other DBs
GO: 0030433 0034976
Organism
Colias croceus (clouded yellow) [GN:ccrc]
Gene
123692609  protein transport protein Sec61 subunit alpha [KO:K10956]
123706124  protein transport protein Sec61 subunit beta [KO:K09481]
123691737  protein transport protein Sec61 subunit gamma [KO:K07342]
123696012  translocation protein SEC62 [KO:K12275]
123692533  translocation protein SEC63 homolog [KO:K09540]
123694538  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
123699374  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
123691404  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
123699585  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
123701187  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
123691776  tumor suppressor candidate 3 [KO:K19478]
123706286  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
123694952  transmembrane protein 258 [KO:K26502]
123702392  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
123697242  hypoxia up-regulated protein 1 [KO:K09486]
123703554  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
123706441  dnaJ homolog shv [KO:K09517]
123691408  uncharacterized protein F54F2.9 [KO:K09521]
123699758  dnaJ homolog subfamily C member 3 [KO:K09523]
123692891  endoplasmin [KO:K09487]
123703886  neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
123694893  glucosidase 2 subunit beta [KO:K08288]
123691631  calnexin [KO:K08054]
123692951  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
123692531  calreticulin [KO:K08057]
123693073  mannosyl-oligosaccharide alpha-1,2-mannosidase IA [KO:K01230] [EC:3.2.1.113]
123705119  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
123702684  vesicular integral-membrane protein VIP36 [KO:K10082]
123703919  protein ERGIC-53 [KO:K10080]
123706259  prolactin regulatory element-binding protein [KO:K14003]
123693006  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
123699755  protein SEC13 homolog [KO:K14004]
123699469  protein transport protein Sec23A isoform X1 [KO:K14006]
123703581  protein transport protein Sec24C isoform X1 [KO:K14007]
123692417  protein transport protein Sec24A [KO:K14007]
123700409  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
123691699  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
123705033  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
123694361  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
123694698  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
123691471  ero1-like protein [KO:K10950] [EC:1.8.4.-]
123694043  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
123694524  translocon-associated protein subunit alpha [KO:K13249]
123695659  translocon-associated protein subunit beta [KO:K13250]
123696415  translocon-associated protein subunit gamma [KO:K13251]
123702270  translocon-associated protein subunit delta [KO:K04571]
123696547  B-cell receptor-associated protein 31 [KO:K14009]
123698640  B-cell receptor-associated protein 31-like [KO:K14009]
123694355  translocating chain-associated membrane protein 1 [KO:K14010]
123701816  derlin-1 [KO:K11519]
123696445  derlin-2 [KO:K13989]
123693553  UBX domain-containing protein 1 [KO:K24348]
123703102  UBX domain-containing protein 6 [KO:K14011]
123703231  NSFL1 cofactor p47 [KO:K14012]
123700989  small VCP/p97-interacting protein [KO:K14014]
123698933  transitional endoplasmic reticulum ATPase TER94 isoform X1 [KO:K13525]
123695397  nuclear protein localization protein 4 homolog [KO:K14015]
123700242  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
123700564  heat shock protein 68-like [KO:K03283]
123703557  heat shock protein 68-like [KO:K03283]
123704021  heat shock protein 68-like [KO:K03283]
123692423  heat shock protein 68-like [KO:K03283]
123692968  heat shock 70 kDa protein cognate 4 [KO:K03283]
123694883  heat shock protein 68-like [KO:K03283]
123693089  dnaJ homolog subfamily A member 4 [KO:K09502]
123705995  dnaJ homolog subfamily A member 2-like [KO:K09503]
123693650  dnaJ protein homolog 1 [KO:K09507]
123702293  dnaJ homolog subfamily B member 14 [KO:K09518]
123699667  dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
123703437  heat shock protein 83 [KO:K04079]
123692050  97 kDa heat shock protein isoform X1 [KO:K09485]
123698932  BAG family molecular chaperone regulator 2 [KO:K09556]
123700306  hsp70-binding protein 1 [KO:K09562]
123695666  protein lethal(2)essential for life-like [KO:K09542]
123695673  protein lethal(2)essential for life-like [KO:K09542]
123699005  protein lethal(2)essential for life [KO:K09542]
123703405  protein lethal(2)essential for life-like [KO:K09542]
123703412  protein lethal(2)essential for life-like [KO:K09542]
123703435  protein lethal(2)essential for life-like [KO:K09542]
123703518  protein lethal(2)essential for life-like [KO:K09542]
123703528  protein lethal(2)essential for life-like [KO:K09542]
123703533  protein lethal(2)essential for life-like [KO:K09542]
123703541  protein lethal(2)essential for life-like [KO:K09542]
123692785  alpha-crystallin B chain-like [KO:K09542]
123703566  alpha-crystallin B chain-like [KO:K09542]
123693310  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
123692209  phospholipase A-2-activating protein [KO:K14018]
123691175  UV excision repair protein RAD23 homolog A-like [KO:K10839]
123698772  ubiquilin-1 [KO:K04523]
123698260  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
123700698  eukaryotic translation initiation factor 2-alpha kinase [KO:K08860] [EC:2.7.11.1]
123702036  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123702760  wolframin isoform X1 [KO:K14020]
123705461  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
123696905  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
123691156  X-box-binding protein 1 [KO:K09027]
123695823  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123693588  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
123698631  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
123698275  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
123694324  E3 ubiquitin-protein ligase MARCHF6 [KO:K10661] [EC:2.3.2.27]
123699445  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
123698382  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
123700093  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
123705032  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
123699634  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
123691424  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
123699999  protein sel-1 homolog 1 isoform X1 [KO:K14026]
123699263  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
123695279  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
123693751  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
123692168  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
123704014  cullin-1 [KO:K03347]
123692167  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ccrc00510  N-Glycan biosynthesis
ccrc03050  Proteasome
ccrc03060  Protein export
KO pathway
ko04141   
LinkDB

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