KEGG   PATHWAY: cfj00260
Entry
cfj00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Colletotrichum fioriniae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cfj00260  Glycine, serine and threonine metabolism
cfj00260

Module
cfj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cfj00260]
cfj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cfj00260]
cfj_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cfj00260]
cfj_M00621  Glycine cleavage system [PATH:cfj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Colletotrichum fioriniae [GN:cfj]
Gene
CFIO01_07582  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CFIO01_01180  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CFIO01_09398  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CFIO01_10910  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CFIO01_11509  homoserine kinase [KO:K00872] [EC:2.7.1.39]
CFIO01_12725  threonine synthase [KO:K01733] [EC:4.2.3.1]
CFIO01_01419  beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
CFIO01_11914  beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
CFIO01_04153  beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
CFIO01_07053  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CFIO01_04239  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CFIO01_06565  alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CFIO01_05987  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CFIO01_07508  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
CFIO01_00496  D-glycerate 3-kinase [KO:K15918] [EC:2.7.1.31]
CFIO01_06413  hypothetical protein [KO:K15918] [EC:2.7.1.31]
CFIO01_06349  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CFIO01_06910  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CFIO01_02462  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
CFIO01_10556  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CFIO01_00499  short chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CFIO01_07728  NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CFIO01_10599  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
CFIO01_07704  flavin containing amine oxidoreductase [KO:K00274] [EC:1.4.3.4]
CFIO01_04670  amine oxidase B [KO:K00274] [EC:1.4.3.4]
CFIO01_00373  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_08408  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_02243  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_05627  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_08978  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_01780  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_08053  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_01924  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_01534  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_00821  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CFIO01_01520  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
CFIO01_12756  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
CFIO01_08096  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CFIO01_09538  glycine cleavage system H protein [KO:K02437]
CFIO01_08563  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
CFIO01_11282  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
CFIO01_12986  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CFIO01_08378  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CFIO01_08082  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CFIO01_04399  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CFIO01_00388  FAD dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
CFIO01_08111  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_00379  fructosyl amino acid oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_08730  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_04831  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_11622  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_08734  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_11894  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_05030  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_07947  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CFIO01_02868  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CFIO01_11779  Cys/Met metabolism PLP-dependent enzyme [KO:K01758] [EC:4.4.1.1]
CFIO01_09706  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CFIO01_02007  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
CFIO01_05764  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
CFIO01_10533  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CFIO01_05050  alanine racemase domain-containing protein [KO:K20498] [EC:4.3.1.18]
CFIO01_00084  hypothetical protein [KO:K20498] [EC:4.3.1.18]
CFIO01_00702  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cfj00010  Glycolysis / Gluconeogenesis
cfj00020  Citrate cycle (TCA cycle)
cfj00230  Purine metabolism
cfj00250  Alanine, aspartate and glutamate metabolism
cfj00270  Cysteine and methionine metabolism
cfj00290  Valine, leucine and isoleucine biosynthesis
cfj00300  Lysine biosynthesis
cfj00330  Arginine and proline metabolism
cfj00460  Cyanoamino acid metabolism
cfj00470  D-Amino acid metabolism
cfj00564  Glycerophospholipid metabolism
cfj00600  Sphingolipid metabolism
cfj00620  Pyruvate metabolism
cfj00630  Glyoxylate and dicarboxylate metabolism
cfj00640  Propanoate metabolism
cfj00680  Methane metabolism
cfj00860  Porphyrin metabolism
cfj00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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