KEGG   PATHWAY: cge00982
Entry
cge00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Cricetulus griseus (Chinese hamster)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cge00982  Drug metabolism - cytochrome P450
cge00982

Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100750494  Fmo5; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100750993  Fmo1; dimethylaniline monooxygenase [N-oxide-forming] 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100751286  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100751580  dimethylaniline monooxygenase [N-oxide-forming] 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100753048  Fmo4; dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100753345  Fmo2; dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100773198  flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100773480  flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100754357  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100753172  glutathione S-transferase alpha-5 [KO:K00799] [EC:2.5.1.18]
100753467  glutathione S-transferase alpha-3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100753770  glutathione S-transferase A6 isoform X2 [KO:K00799] [EC:2.5.1.18]
100757858  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100768110  glutathione S-transferase Mu 6 isoform X1 [KO:K00799] [EC:2.5.1.18]
100766772  glutathione S-transferase Y1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100767530  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
100750644  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
100750357  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100758427  Gsto1; glutathione S-transferase omega-1 isoform X5 [KO:K00799] [EC:2.5.1.18]
100753857  glutathione S-transferase A2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100759107  glutathione S-transferase omega-2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100750937  glutathione S-transferase Mu 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100768553  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100752137  glutathione S-transferase A2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100753254  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100774867  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100759236  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100766034  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
100765453  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
100764249  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100765742  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
113835189  glutathione S-transferase A2-like isoform X2 [KO:K00799] [EC:2.5.1.18]
113835190  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
100767818  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100689311  Gstp1; glutathione S-transferase P 1 [KO:K23790] [EC:2.5.1.18]
100757534  glutathione S-transferase P 2 isoform X1 [KO:K23790] [EC:2.5.1.18]
100750404  Gstk1; glutathione S-transferase kappa 1 isoform X2 [KO:K13299] [EC:2.5.1.18]
100750691  glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
100768035  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100756617  alcohol dehydrogenase 1 isoform X2 [KO:K13951] [EC:1.1.1.1]
100773005  alcohol dehydrogenase 1 isoform X2 [KO:K13951] [EC:1.1.1.1]
100759210  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
100760081  alcohol dehydrogenase 1 isoform X2 [KO:K13951] [EC:1.1.1.1]
100767633  all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X2 [KO:K13980] [EC:1.1.1.1]
100767929  Adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100767061  alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
100755596  aldehyde dehydrogenase family 3 member B1 isoform X2 [KO:K00129] [EC:1.2.1.5]
100757371  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
100763332  Aldh3b2; aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
100760815  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
100759648  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100765484  aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
100760212  aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
100759157  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
113830655  aldehyde oxidase 1 isoform X2 [KO:K00157] [EC:1.2.3.1]
100760504  aldehyde oxidase 3 isoform X2 [KO:K00157] [EC:1.2.3.1]
100762963  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
100762673  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
100762380  UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
100758624  UDP-glucuronosyltransferase 2B17 isoform X2 [KO:K00699] [EC:2.4.1.17]
100763538  UDP-glucuronosyltransferase 2B7 isoform X2 [KO:K00699] [EC:2.4.1.17]
100751639  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3-like isoform X2 [KO:K00699] [EC:2.4.1.17]
103158560  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
100772229  UDP-glucuronosyltransferase 2B17-like isoform X2 [KO:K00699] [EC:2.4.1.17]
100763430  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
100751325  UDP-glucuronosyltransferase 2B31 isoform X1 [KO:K00699] [EC:2.4.1.17]
113832765  UDP-glucuronosyltransferase 2B31-like isoform X2 [KO:K00699] [EC:2.4.1.17]
100751798  UDP-glucuronosyltransferase 2B31 isoform X2 [KO:K00699] [EC:2.4.1.17]
113832766  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
100750340  UDP-glucuronosyltransferase 2B1 isoform X3 [KO:K00699] [EC:2.4.1.17]
113832767  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
100755423  UDP-glucuronosyltransferase 1-7C isoform X1 [KO:K00699] [EC:2.4.1.17]
118237867  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
118238327  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
113833621  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
118238328  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
100750549  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-8-like isoform X2 [KO:K00699] [EC:2.4.1.17]
118237869  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
100755851  cytochrome P450 1A2 isoform X2 [KO:K07409] [EC:1.14.14.1]
100765891  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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