KEGG   PATHWAY: cgib00983
Entry
cgib00983                   Pathway                                
Name
Drug metabolism - other enzymes - Carassius gibelio (silver crucian carp)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cgib00983  Drug metabolism - other enzymes
cgib00983

Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127971323  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
127947154  hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
128013716  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
128027262  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
127963461  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
127933785  inosine-5'-monophosphate dehydrogenase 1a-like [KO:K00088] [EC:1.1.1.205]
127956742  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
127974377  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
127977010  inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
128018581  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
127934355  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
127977728  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
127935394  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127978543  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127933610  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127976496  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127983928  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
127938939  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
128014156  uncharacterized protein LOC128014156 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128014118  pyrethroid hydrolase Ces2a-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
127963576  UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
127983785  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127965067  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127945932  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
127934383  UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
127946746  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127966413  UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
127957849  UDP glucuronosyltransferase 2 family, polypeptide B6 isoform X1 [KO:K00699] [EC:2.4.1.17]
127948591  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127948593  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
127958781  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127968247  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127968249  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
127961342  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
128021231  UDP glucuronosyltransferase 5 family, polypeptide G2 [KO:K00699] [EC:2.4.1.17]
128014293  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128014294  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
128014523  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128022217  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128017171  UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
127990013  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127990069  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127990085  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128018871  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
128019681  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127958053  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
128014904  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
127944613  cytidine deaminase-like isoform X1 [KO:K01489] [EC:3.5.4.5]
127935181  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
128022602  cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
128017210  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
128011210  cytidine deaminase a [KO:K01489] [EC:3.5.4.5]
127956340  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
127977007  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
127951434  LOW QUALITY PROTEIN: dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
127946544  dihydropyrimidine dehydrogenase [NADP(+)]-like isoform X1 [KO:K00207] [EC:1.3.1.2]
128027277  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
128030006  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
127962944  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
128018527  beta-ureidopropionase-like isoform X1 [KO:K01431] [EC:3.5.1.6]
127970588  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
127970800  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
127975060  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
128031217  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
128020215  uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
127962912  uridine-cytidine kinase-like 1a isoform X1 [KO:K00876] [EC:2.7.1.48]
127963454  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
127944566  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127938735  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127941282  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
127951037  uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
127984406  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
128025508  uridine-cytidine kinase 2-B-like [KO:K00876] [EC:2.7.1.48]
128018742  uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
128012190  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127961697  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
127968566  thymidine kinase, cytosolic-like isoform X1 [KO:K00857] [EC:2.7.1.21]
128021945  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
128016710  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
127964456  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
128019661  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
127951582  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
128025432  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
127942045  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
127986385  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
127935085  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
127938948  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
127978554  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
127984438  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
127951800  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
127983364  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
127953604  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
127955031  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
127934901  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
127947691  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127938066  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
127969159  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
128015587  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
128025218  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
127977563  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
127962690  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like isoform X1 [KO:K00622] [EC:2.3.1.5]
127962693  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
127934489  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
127949349  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like isoform X1 [KO:K00622] [EC:2.3.1.5]
127977538  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
127970546  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127970790  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127962947  glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
127963074  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
127963076  glutathione S-transferase mu tandem duplicate 3 [KO:K00799] [EC:2.5.1.18]
127956643  microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
127956644  microsomal glutathione S-transferase 1.2 [KO:K00799] [EC:2.5.1.18]
127957338  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127935227  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127969658  glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
127941348  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
127969936  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127978687  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127978688  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
128014238  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
127984541  microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
127986609  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
128025910  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128026206  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
128026562  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128018639  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128027540  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
127971698  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
128027703  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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