KEGG   PATHWAY: cmax00053
Entry
cmax00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Cucurbita maxima (winter squash)
Class
Metabolism; Carbohydrate metabolism
Pathway map
cmax00053  Ascorbate and aldarate metabolism
cmax00053

Module
cmax_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:cmax00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Cucurbita maxima (winter squash) [GN:cmax]
Gene
111492955  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
111479929  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
111485358  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
111487149  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
111487734  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
111489376  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
111479862  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
111485296  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
111465615  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
111493835  inositol oxygenase 4-like isoform X1 [KO:K00469] [EC:1.13.99.1]
111470262  aldose reductase [KO:K00002] [EC:1.1.1.2]
111466251  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
111478279  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
111474382  LOW QUALITY PROTEIN: probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
111465572  GDP-mannose 3,5-epimerase 2-like isoform X1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
111493789  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
111480581  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
111476994  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
111495334  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
111478849  inositol monophosphatase 1-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
111466554  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
111495495  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
111484263  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
111471025  L-galactose dehydrogenase isoform X1 [KO:K17744] [EC:1.1.1.316]
111465966  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
111468616  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
111499004  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
111493970  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
111465031  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
111495400  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
111485780  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
111494487  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
111471241  UDP-glucuronate 4-epimerase 2-like [KO:K08679] [EC:5.1.3.6]
111472742  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
111487459  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
111469045  monodehydroascorbate reductase, chloroplastic/mitochondrial [KO:K08232] [EC:1.6.5.4]
111478497  monodehydroascorbate reductase 4, cytosolic-like [KO:K08232] [EC:1.6.5.4]
111486955  monodehydroascorbate reductase 4, peroxisomal-like isoform X1 [KO:K08232] [EC:1.6.5.4]
111471214  monodehydroascorbate reductase, seedling isozyme [KO:K08232] [EC:1.6.5.4]
111489099  monodehydroascorbate reductase 4, peroxisomal-like isoform X1 [KO:K08232] [EC:1.6.5.4]
111481646  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
111483271  monodehydroascorbate reductase, seedling isozyme-like isoform X1 [KO:K08232] [EC:1.6.5.4]
111486242  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
111489480  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
111499924  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
111478732  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
111492742  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
111468480  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
111487023  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
111496267  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
111484522  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
111469373  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
111483874  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111483885  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111482062  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111476861  glutathione S-transferase DHAR2-like isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111466657  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
111490929  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
111490931  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
111490934  L-ascorbate oxidase homolog isoform X1 [KO:K00423] [EC:1.10.3.3]
111472953  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
111495278  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
111483759  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
111483763  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
111485412  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
111482755  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
111498024  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
111496434  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
111490731  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
111491755  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
111477050  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
111477051  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
111480266  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
111488616  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
cmax00020  Citrate cycle (TCA cycle)
cmax00040  Pentose and glucuronate interconversions
cmax00051  Fructose and mannose metabolism
cmax00520  Amino sugar and nucleotide sugar metabolism
cmax00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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