KEGG   PATHWAY: cmo00600
Entry
cmo00600                    Pathway                                
Name
Sphingolipid metabolism - Cucumis melo (muskmelon)
Class
Metabolism; Lipid metabolism
Pathway map
cmo00600  Sphingolipid metabolism
cmo00600

Module
cmo_M00100  Sphingosine degradation [PATH:cmo00600]
Other DBs
GO: 0006665
Organism
Cucumis melo (muskmelon) [GN:cmo]
Gene
103502283  long chain base biosynthesis protein 2a [KO:K00654] [EC:2.3.1.50]
103487868  long chain base biosynthesis protein 1 [KO:K00654] [EC:2.3.1.50]
103483732  3-dehydrosphinganine reductase TSC10A [KO:K04708] [EC:1.1.1.102]
103502048  neutral ceramidase 1 isoform X1 [KO:K12349] [EC:3.5.1.23]
103497106  neutral ceramidase 2-like isoform X1 [KO:K12349] [EC:3.5.1.23]
103502652  neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]
103483475  alkaline ceramidase-like [KO:K04711] [EC:3.5.1.-]
103484652  alkaline ceramidase isoform X1 [KO:K04711] [EC:3.5.1.-]
103486276  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
103485785  sphinganine C4-monooxygenase 1-like [KO:K04713] [EC:1.14.18.5]
103489111  sphinganine C4-monooxygenase 2 [KO:K04713] [EC:1.14.18.5]
103482566  ceramide kinase isoform X3 [KO:K04715] [EC:2.7.1.138]
103484546  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
103498855  sphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]
103502562  uncharacterized protein LOC103502562 isoform X2 [KO:K17108] [EC:3.2.1.45]
103496976  uncharacterized protein LOC103496976 isoform X1 [KO:K17108] [EC:3.2.1.45]
103498676  uncharacterized protein LOC103498676 isoform X2 [KO:K17108] [EC:3.2.1.45]
103489515  uncharacterized protein LOC103489515 [KO:K01190] [EC:3.2.1.23]
103502003  beta-galactosidase 17 isoform X2 [KO:K12309] [EC:3.2.1.23]
103488793  alpha-galactosidase 1 [KO:K07407] [EC:3.2.1.22]
103496737  alpha-galactosidase 3 isoform X1 [KO:K07407] [EC:3.2.1.22]
103488794  alpha-galactosidase isoform X1 [KO:K07407] [EC:3.2.1.22]
103503058  beta-hexosaminidase 2 [KO:K12373] [EC:3.2.1.52]
103500188  beta-hexosaminidase 1 [KO:K12373] [EC:3.2.1.52]
103485909  beta-hexosaminidase 3 [KO:K12373] [EC:3.2.1.52]
103502188  uncharacterized protein LOC103502188 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cmo00260  Glycine, serine and threonine metabolism
cmo00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cmo00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cmo00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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