KEGG   PATHWAY: cnt00260
Entry
cnt00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cedecea neteri SSMD04
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cnt00260  Glycine, serine and threonine metabolism
cnt00260

Module
cnt_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cnt00260]
cnt_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cnt00260]
cnt_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cnt00260]
cnt_M00555  Betaine biosynthesis, choline => betaine [PATH:cnt00260]
cnt_M00621  Glycine cleavage system [PATH:cnt00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cedecea neteri SSMD04 [GN:cnt]
Gene
JT31_11125  aspartate kinase [KO:K00928] [EC:2.7.2.4]
JT31_09135  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
JT31_11910  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
JT31_13770  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
JT31_09130  serine kinase [KO:K00872] [EC:2.7.1.39]
JT31_09125  threonine synthase [KO:K01733] [EC:4.2.3.1]
JT31_05355  threonine aldolase [KO:K01620] [EC:4.1.2.48]
JT31_17620  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
JT31_04630  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
JT31_12785  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
JT31_14705  glycerate kinase [KO:K00865] [EC:2.7.1.165]
JT31_06095  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
JT31_09195  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
JT31_12105  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
JT31_04810  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
JT31_15990  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
JT31_05190  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
JT31_09230  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
JT31_01695  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
JT31_12125  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
JT31_12120  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
JT31_00450  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
JT31_16035  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
JT31_16025  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
JT31_08665  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
JT31_16030  glycine cleavage system protein H [KO:K02437]
JT31_17325  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
JT31_00970  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
JT31_00965  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
JT31_18845  phenylacetaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
JT31_00800  cystathionine beta-lyase [KO:K01697] [EC:4.2.1.22]
JT31_00795  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
JT31_16480  serine dehydratase [KO:K01752] [EC:4.3.1.17]
JT31_22135  serine dehydratase [KO:K01752] [EC:4.3.1.17]
JT31_11755  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
JT31_15945  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
JT31_13160  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
JT31_16280  racemase [KO:K25316] [EC:5.1.1.10]
JT31_23070  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
JT31_23075  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
JT31_10940  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
JT31_10945  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cnt00010  Glycolysis / Gluconeogenesis
cnt00020  Citrate cycle (TCA cycle)
cnt00230  Purine metabolism
cnt00250  Alanine, aspartate and glutamate metabolism
cnt00270  Cysteine and methionine metabolism
cnt00290  Valine, leucine and isoleucine biosynthesis
cnt00300  Lysine biosynthesis
cnt00330  Arginine and proline metabolism
cnt00460  Cyanoamino acid metabolism
cnt00470  D-Amino acid metabolism
cnt00564  Glycerophospholipid metabolism
cnt00600  Sphingolipid metabolism
cnt00620  Pyruvate metabolism
cnt00630  Glyoxylate and dicarboxylate metabolism
cnt00640  Propanoate metabolism
cnt00680  Methane metabolism
cnt00860  Porphyrin metabolism
cnt00920  Sulfur metabolism
KO pathway
ko00260   
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