KEGG PATHWAY: crg04330

KEGG

PATHWAY: crg04330

Entry

crg04330                    Pathway

Name

Notch signaling pathway - Magallana gigas (Pacific oyster)

Description

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Class

Environmental Information Processing; Signal transduction

Pathway map

Notch signaling pathway

Other DBs

GO:

Organism

Magallana gigas (Pacific oyster) [GN:crg]

Gene

protein jagged-1 [KO:K06051]

delta-like protein 1 [KO:K06051]

delta-like protein 1 isoform X1 [KO:K06051]

uncharacterized protein LOC105337853 [KO:K06052]

protein jagged-1b [KO:K06052]

fringe glycosyltransferase-like [KO:K05948] [EC:2.4.1.222]

protein crumbs isoform X4 [KO:K02599]

neurogenic locus notch homolog protein 1 isoform X2 [KO:K02599]

recombining binding protein suppressor of hairless isoform X1 [KO:K06053]

protein hairy [KO:K06054]

protein hairy isoform X1 [KO:K06054]

uncharacterized protein LOC105327843 [KO:K06054]

uncharacterized protein LOC105327857 [KO:K06054]

enhancer of split m7 protein-like [KO:K06054]

transcription factor HES-2-like [KO:K06054]

transcription factor HES-2 [KO:K06054]

transcription factor HES-4-A [KO:K06054]

transcription factor HES-1 [KO:K06054]

uncharacterized protein LOC117680718 [KO:K06054]

uncharacterized protein LOC117680719 [KO:K06054]

hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]

notch-regulated ankyrin repeat-containing protein [KO:K26480]

segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]

protein numb-like isoform X1 [KO:K06057]

E3 ubiquitin-protein ligase DTX1 isoform X1 [KO:K06058] [EC:2.3.2.27]

uncharacterized protein LOC105332283 [KO:K06058] [EC:2.3.2.27]

uncharacterized protein LOC105343755 isoform X1 [KO:K06058] [EC:2.3.2.27]

uncharacterized protein LOC105335881 [KO:K06058] [EC:2.3.2.27]

ADAM 17-like protease isoform X2 [KO:K06059] [EC:3.4.24.86]

ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]

ADAM 17-like protease isoform X1 [KO:K06059] [EC:3.4.24.86]

ADAM 17-like protease isoform X1 [KO:K06059] [EC:3.4.24.86]

ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]

presenilin-1 [KO:K04522] [EC:3.4.23.-]

nicastrin isoform X1 [KO:K06171]

gamma-secretase subunit Aph-1 [KO:K06172]

ataxin-2 homolog isoform X1 [KO:K06061]

CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]

histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]

SNW domain-containing protein 1 [KO:K06063]

C-terminal-binding protein 1-like [KO:K04496] [EC:1.1.1.428]

transducin-like enhancer protein 4 isoform X2 [KO:K04497]

corepressor interacting with RBPJ 1 [KO:K06066]

corepressor interacting with RBPJ 1-like [KO:K06066]

LOW QUALITY PROTEIN: uncharacterized protein LOC105328669 [KO:K25100]

probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]

uncharacterized protein LOC105328589 isoform X1 [KO:K23616]

Compound

Notch intracellular domain

Reference

Authors

Hansson EM, Lendahl U, Chapman G.

Title

Notch signaling in development and disease.

Journal

Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011

Reference

Authors

Callahan R, Egan SE.

Title

Notch signaling in mammary development and oncogenesis.

Journal

J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81

Reference

Authors

Zweidler-McKay PA, Pear WS.

Title

Notch and T cell malignancy.

Journal

Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012

Reference

Authors

Wu L, Griffin JD.

Title

Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.

Journal

Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014

Reference

Authors

Tsukumo S, Yasutomo K.

Title

Notch governing mature T cell differentiation.

Journal

J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109

Reference

Authors

Haltiwanger RS.

Title

Regulation of signal transduction pathways in development by glycosylation.

Journal

Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8

Reference

Authors

Koo EH, Kopan R.

Title

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Journal

Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065

Reference

Authors

Okano H, Imai T, Okabe M.

Title

Musashi: a translational regulator of cell fate.

Journal

J Cell Sci 115:1355-9 (2002)

Reference

Authors

Haltiwanger RS, Stanley P.

Title

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.

Journal

Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2

Reference

Authors

Das G, Reynolds-Kenneally J, Mlodzik M.

Title

The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.

Journal

Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8

Reference

Authors

Cooper MT, Bray SJ.

Title

Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.

Journal

Nature 397:526-30 (1999)
DOI:10.1038/17395

Reference

Authors

Tanigaki K, Kuroda K, Han H, Honjo T.

Title

Regulation of B cell development by Notch/RBP-J signaling.

Journal

Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3

KO pathway

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