KEGG   PATHWAY: csav00053
Entry
csav00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Cannabis sativa (hemp)
Class
Metabolism; Carbohydrate metabolism
Pathway map
csav00053  Ascorbate and aldarate metabolism
csav00053

Module
csav_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:csav00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Cannabis sativa (hemp) [GN:csav]
Gene
115700715  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
115709730  LOW QUALITY PROTEIN: UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
115698731  UDP-sugar pyrophosphorylase isoform X1 [KO:K12447] [EC:2.7.7.64]
115699491  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
115722958  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
115705058  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
115707556  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
115707575  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
115708313  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
115722490  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
115696860  NADPH-dependent aldo-keto reductase, chloroplastic isoform X1 [KO:K00002] [EC:1.1.1.2]
115697632  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
115698079  aldose reductase [KO:K00002] [EC:1.1.1.2]
115704179  probable truncated L-gulonolactone oxidase 7, mitochondrial [KO:K00103] [EC:1.1.3.8]
115704660  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
115704717  L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
115704776  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
115705069  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
115719031  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
115724084  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
115697215  GDP-L-galactose phosphorylase 1 isoform X1 [KO:K14190] [EC:2.7.7.69]
115725518  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
115707333  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
115695844  bifunctional phosphatase IMPL2, chloroplastic isoform X1 [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
115704241  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
115710146  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
115711288  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
115722406  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
115716429  UDP-glucuronate 4-epimerase 2 [KO:K08679] [EC:5.1.3.6]
115706328  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
115694784  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
115723940  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
115699645  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
115716638  monodehydroascorbate reductase, chloroplastic/mitochondrial [KO:K08232] [EC:1.6.5.4]
115709328  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
115724575  monodehydroascorbate reductase 1, peroxisomal isoform X1 [KO:K08232] [EC:1.6.5.4]
115719381  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
115702667  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
115702668  probable L-ascorbate peroxidase 3, peroxisomal isoform X1 [KO:K00434] [EC:1.11.1.11]
115704704  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
115706904  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
115707840  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
115709468  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
115711955  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
115702075  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
115702896  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
115705678  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
115707810  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
115698725  glutathione S-transferase DHAR2 isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
115719238  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
115719239  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
115697018  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
115697816  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
115721408  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
115712756  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
115714851  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
115715183  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
115707863  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
115709636  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
115706478  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
csav00020  Citrate cycle (TCA cycle)
csav00040  Pentose and glucuronate interconversions
csav00051  Fructose and mannose metabolism
csav00520  Amino sugar and nucleotide sugar metabolism
csav00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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