KEGG   PATHWAY: csin00053
Entry
csin00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Camellia sinensis (tea plant)
Class
Metabolism; Carbohydrate metabolism
Pathway map
csin00053  Ascorbate and aldarate metabolism
csin00053

Module
csin_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:csin00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Camellia sinensis (tea plant) [GN:csin]
Gene
114308278  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
114310476  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
114284090  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
114291695  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
114275234  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
114267052  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
114300528  glucuronokinase 1-like isoform X1 [KO:K16190] [EC:2.7.1.43]
114320947  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
114320964  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
114320965  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
114306321  uncharacterized protein LOC114306321 [KO:K00469] [EC:1.13.99.1]
114313348  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
114261827  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
114304697  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
114264197  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
114285330  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
114287723  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
114297399  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
114285431  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
114273538  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
114297415  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
114321799  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
114266476  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
114268684  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
114276226  probable L-gulonolactone oxidase 6 isoform X1 [KO:K00103] [EC:1.1.3.8]
114323341  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
114298671  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
114308609  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
114280109  GDP-L-galactose phosphorylase 2-like isoform X1 [KO:K14190] [EC:2.7.7.69]
114271581  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
114274125  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
114256612  GDP-D-glucose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
114277410  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
114309059  inositol-phosphate phosphatase-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
114295583  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
114267151  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
114284603  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
114256949  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
114321044  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
114323691  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
114307108  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
114307402  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
114262045  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
114298289  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
114311083  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
114323822  monodehydroascorbate reductase, chloroplastic/mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
114280285  monodehydroascorbate reductase 4, peroxisomal isoform X1 [KO:K08232] [EC:1.6.5.4]
114284032  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
114279341  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
114311391  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
114284060  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
114285269  L-ascorbate peroxidase 3-like isoform X1 [KO:K00434] [EC:1.11.1.11]
114265311  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
114289093  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
114298111  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
114279703  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
114274471  uncharacterized protein LOC114274471 isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
114275044  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
114278095  LOW QUALITY PROTEIN: glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
114323084  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
114283398  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
114266555  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
114318501  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
114280942  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
114262334  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
114264818  aldehyde dehydrogenase family 3 member F1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
114265516  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
114288457  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
114267533  uncharacterized protein LOC114267533 [KO:K00128] [EC:1.2.1.3]
114290431  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
114298736  LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
114307188  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
csin00020  Citrate cycle (TCA cycle)
csin00040  Pentose and glucuronate interconversions
csin00051  Fructose and mannose metabolism
csin00520  Amino sugar and nucleotide sugar metabolism
csin00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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