KEGG   PATHWAY: ctul00983
Entry
ctul00983                   Pathway                                
Name
Drug metabolism - other enzymes - Cyprinodon tularosa (White Sands pupfish)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ctul00983  Drug metabolism - other enzymes
ctul00983

Organism
Cyprinodon tularosa (White Sands pupfish) [GN:ctul]
Gene
119788132  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
119793072  hprt1l; hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
119789089  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
119789340  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
119793111  inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
119783847  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
119778630  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
119791561  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119797723  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
119793101  ces2b; neuroligin-1 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
119775950  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119795798  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119795799  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 isoform X1 [KO:K00699] [EC:2.4.1.17]
119776834  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
119776865  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119776866  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119776868  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119796251  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119797364  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
119797921  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
119797922  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
119797928  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119797931  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119797933  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119779221  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119779222  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119792911  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119792955  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119793000  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119787365  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119793368  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
119775640  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
119791741  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
119773317  zgc:103586 [KO:K01489] [EC:3.5.4.5]
119796571  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
119774143  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
119776611  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
119775609  upb1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
119783877  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
119772803  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
119776056  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
119776581  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
119795907  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119799319  uckl1a; uridine-cytidine kinase-like 1a isoform X1 [KO:K00876] [EC:2.7.1.48]
119774106  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119787681  uck2a; uridine-cytidine kinase 2-A isoform X1 [KO:K00876] [EC:2.7.1.48]
119783321  tk1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
119792661  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
119785181  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
119774550  cmpk; LOW QUALITY PROTEIN: UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
119789586  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
119797348  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119789418  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119789430  ribonucleoside-diphosphate reductase subunit M2-like isoform X1 [KO:K10808] [EC:1.17.4.1]
119784805  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
119781745  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
119781767  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
119795736  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
119796912  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
119778519  nucleoside diphosphate kinase B-like isoform X1 [KO:K00940] [EC:2.7.4.6]
119785120  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
119782430  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
119781943  si:dkey-78a14.4; arylamine N-acetyltransferase, pineal gland isozyme NAT-10 isoform X1 [KO:K00622] [EC:2.3.1.5]
119775137  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119782172  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
119788395  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
119776076  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119795825  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
119789926  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
119784652  gstr; glutathione S-transferase rho [KO:K00799] [EC:2.5.1.18]
119784653  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119784654  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119784661  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119790688  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
119790849  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
119790868  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
119797062  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
119797437  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119784662  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
119797459  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119791842  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
119774166  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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