KEGG   PATHWAY: dci04141
Entry
dci04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Diaphorina citri (Asian citrus psyllid)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dci04141  Protein processing in endoplasmic reticulum
dci04141

Other DBs
GO: 0030433 0034976
Organism
Diaphorina citri (Asian citrus psyllid) [GN:dci]
Gene
103510285  protein transport protein Sec61 subunit alpha isoform X2 [KO:K10956]
103507004  protein transport protein Sec61 subunit beta-like [KO:K09481]
103507007  protein transport protein Sec61 subunit beta-like [KO:K09481]
103519105  protein transport protein Sec61 gamma-1 subunit [KO:K07342]
103518213  translocation protein SEC62 isoform X1 [KO:K12275]
103505075  translocation protein SEC63 homolog [KO:K09540]
103505072  translocation protein SEC63 homolog isoform X2 [KO:K09540]
103507955  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
103524012  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
103515080  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
103518322  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
103522443  tumor suppressor candidate 3-like [KO:K19478]
103523206  tumor suppressor candidate 3-like [KO:K19478]
103504992  oligosaccharyltransferase complex subunit OSTC isoform X1 [KO:K26501]
103521929  transmembrane protein 258 [KO:K26502]
103521930  transmembrane protein 258 [KO:K26502]
108251859  transmembrane protein 258-like [KO:K26502]
103515416  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
103513268  nucleotide exchange factor SIL1 [KO:K14001]
103523428  hypoxia up-regulated protein 1-like [KO:K09486]
103511186  hypoxia up-regulated protein 1-like [KO:K09486]
103513817  LOW QUALITY PROTEIN: endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
103512511  dnaJ homolog shv isoform X1 [KO:K09517]
103524879  uncharacterized protein F54F2.9 [KO:K09521]
103520499  dnaJ homolog subfamily C member 3 [KO:K09523]
103511108  endoplasmin homolog [KO:K09487]
103517213  LOW QUALITY PROTEIN: neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
103508037  glucosidase 2 subunit beta [KO:K08288]
103509307  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
103507061  calreticulin [KO:K08057]
103506272  mannosyl-oligosaccharide alpha-1,2-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
103512631  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
103521396  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
103514454  VIP36-like protein isoform X1 [KO:K10082]
103504816  protein ERGIC-53 [KO:K10080]
103516274  prolactin regulatory element-binding protein [KO:K14003]
103524401  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
103515799  GTP-binding protein SAR1 [KO:K07953] [EC:3.6.5.-]
103516503  protein SEC13 homolog isoform X1 [KO:K14004]
103514510  protein transport protein Sec23A [KO:K14006]
103519606  LOW QUALITY PROTEIN: protein transport protein Sec23A [KO:K14006]
103523360  protein transport protein Sec24A [KO:K14007]
103523510  protein transport protein Sec24A isoform X1 [KO:K14007]
103505489  protein transport protein Sec24A isoform X1 [KO:K14007]
103512163  collagen alpha-1(III) chain [KO:K14007]
103512957  LOW QUALITY PROTEIN: UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
103510601  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
103520902  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
103524967  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
103513227  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
103523841  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
103515126  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
103508798  translocon-associated protein subunit alpha [KO:K13249]
113465293  translocon-associated protein subunit beta-like [KO:K13250]
103523921  translocon-associated protein subunit beta [KO:K13250]
103505758  translocon-associated protein subunit gamma [KO:K13251]
103511651  LOW QUALITY PROTEIN: translocating chain-associated membrane protein 1 [KO:K14010]
103523562  derlin-1 [KO:K11519]
103514630  derlin-2 [KO:K13989]
103515207  UBX domain-containing protein 1-B-like [KO:K24348]
103510148  UBX domain-containing protein 1-like [KO:K24348]
103510149  UBX domain-containing protein 1-B-like [KO:K24348]
103518784  UBX domain-containing protein 6-like [KO:K14011]
103519175  NSFL1 cofactor p47 [KO:K14012]
113467371  uncharacterized protein LOC113467371 [KO:K14014]
103520429  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
103513939  heat shock protein 70 A1-like isoform X1 [KO:K03283]
103513940  heat shock protein 70 A1-like [KO:K03283]
103513941  heat shock protein 70 A1-like [KO:K03283]
103513952  heat shock protein 68-like [KO:K03283]
103522980  heat shock 70 kDa protein cognate 4 [KO:K03283]
103523236  heat shock 70 kDa protein cognate 4-like [KO:K03283]
103506759  heat shock 70 kDa protein cognate 2-like [KO:K03283]
103507632  heat shock 70 kDa protein cognate 4-like [KO:K03283]
103524945  heat shock 70 kDa protein cognate 2-like isoform X1 [KO:K03283]
103510637  heat shock 70 kDa protein cognate 4 [KO:K03283]
103513585  dnaJ homolog subfamily A member 1 isoform X1 [KO:K09502]
103513587  dnaJ homolog subfamily A member 1-like [KO:K09502]
103505428  dnaJ homolog subfamily A member 2 [KO:K09503]
103510628  dnaJ protein homolog 1 [KO:K09507]
103514041  dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
103514323  uncharacterized protein LOC103514323 [KO:K04079]
103508055  heat shock protein 83 [KO:K04079]
103506664  97 kDa heat shock protein [KO:K09485]
103510885  heat shock 70 kDa protein 4 [KO:K09485]
103506121  BAG family molecular chaperone regulator 2 [KO:K09556]
103521904  hsp70-binding protein 1-like [KO:K09562]
103521905  hsp70-binding protein 1-like [KO:K09562]
103518841  hsp70-binding protein 1-like isoform X1 [KO:K09562]
103512951  alpha-crystallin A chain-like [KO:K09542]
103523529  protein lethal(2)essential for life-like [KO:K09542]
103523532  protein lethal(2)essential for life-like [KO:K09542]
103523533  protein lethal(2)essential for life-like [KO:K09542]
108253773  uncharacterized protein LOC108253773 [KO:K09542]
103510703  protein lethal(2)essential for life-like isoform X1 [KO:K09542]
103510085  protein lethal(2)essential for life-like [KO:K09542]
103516490  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
103514884  phospholipase A-2-activating protein [KO:K14018]
103516440  phospholipase A-2-activating protein-like [KO:K14018]
103506324  ubiquilin-1 [KO:K04523]
103508141  ubiquilin-4-like [KO:K04523]
103519922  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
103525021  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
103513682  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103519200  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
103523758  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103523759  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103511504  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103515602  uncharacterized protein LOC103515602 [KO:K08653] [EC:3.4.21.112]
103506987  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103511857  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
103512031  dual specificity mitogen-activated protein kinase kinase hemipterous-like [KO:K04431] [EC:2.7.12.2]
103508970  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
103521221  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103511715  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
103515122  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
103510674  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
103505198  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
103508243  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
103515445  E3 ubiquitin-protein ligase synoviolin A-like [KO:K10601] [EC:2.3.2.27]
103509109  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
103516786  selenoprotein S [KO:K14025]
103504909  selenoprotein S-like [KO:K14025]
103518326  protein sel-1 homolog 1-like [KO:K14026]
103511256  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
103507136  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
103505014  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
103511407  RING-box protein 1A isoform X2 [KO:K03868] [EC:2.3.2.32]
103524839  RING-box protein pip1-like [KO:K03868] [EC:2.3.2.32]
103524844  RING-box protein pip1-like [KO:K03868] [EC:2.3.2.32]
103512398  S-phase kinase-associated protein 1 [KO:K03094]
103512400  S-phase kinase-associated protein 1 [KO:K03094]
103516987  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dci00510  N-Glycan biosynthesis
dci03050  Proteasome
dci03060  Protein export
KO pathway
ko04141   
LinkDB

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