Entry
Name
Spliceosome - Delphinapterus leucas (beluga whale)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Delphinapterus leucas (beluga whale) [GN:
dle ]
Gene
111179565 DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815 ] [EC:5.6.2.6 ]
111184368 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
111181455 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087 ]
111180634 SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093 ]
111172763 PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821 ]
111174026 PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821 ]
111183054 TCERG1; LOW QUALITY PROTEIN: transcription elongation regulator 1 [KO:K12824 ]
111186338 PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834 ]
111181200 U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836 ]
111163808 U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836 ]
111180572 U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
111165100 PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838 ]
111172316 SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839 ]
111166520 CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841 ]
111179273 U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842 ]
111169758 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
111177305 PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662 ]
111167919 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846 ]
111165415 USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847 ]
111170201 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
111175488 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
111170417 HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283 ]
111163337 LOW QUALITY PROTEIN: pre-mRNA-splicing factor SYF2-like [KO:K12868 ]
111174456 CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871 ]
111164099 ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875 ]
111187941 NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882 ]
111172329 NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883 ]
111165798 NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883 ]
111180388 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111168823 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111171984 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111173921 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
111179872 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111172906 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
111171157 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111172644 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111168125 heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741 ]
111179862 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111177699 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111165679 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111165695 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111165023 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111172504 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741 ]
111181822 HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
111166801 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
111166207 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X12 [KO:K12887 ]
111177551 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
111173020 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
111177240 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893 ]
111184163 SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893 ]
111163213 SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893 ]
111174866 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
111182061 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
111163457 SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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