KEGG   PATHWAY: dle03040
Entry
dle03040                    Pathway                                
Name
Spliceosome - Delphinapterus leucas (beluga whale)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
dle03040  Spliceosome
dle03040

Other DBs
GO: 0005681
Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
115803557  U1 spliceosomal RNA [KO:K14276]
115801798  U1 spliceosomal RNA [KO:K14276]
115802474  U1 spliceosomal RNA [KO:K14276]
115803559  U1 spliceosomal RNA [KO:K14276]
115801646  U1 spliceosomal RNA [KO:K14276]
115801894  U1 spliceosomal RNA [KO:K14276]
115801905  U1 spliceosomal RNA [KO:K14276]
115803035  U1 spliceosomal RNA [KO:K14276]
115804077  U1 spliceosomal RNA [KO:K14276]
115802412  U1 spliceosomal RNA [KO:K14276]
115802690  U1 spliceosomal RNA [KO:K14276]
115803073  U2 spliceosomal RNA [KO:K14277]
115803084  U2 spliceosomal RNA [KO:K14277]
115804181  U2 spliceosomal RNA [KO:K14277]
115803205  U2 spliceosomal RNA [KO:K14277]
115804186  U2 spliceosomal RNA [KO:K14277]
115802240  U2 spliceosomal RNA [KO:K14277]
115803676  U2 spliceosomal RNA [KO:K14277]
115804127  U4 spliceosomal RNA [KO:K14278]
115804137  U4 spliceosomal RNA [KO:K14278]
115801976  U4 spliceosomal RNA [KO:K14278]
115801728  U4 spliceosomal RNA [KO:K14278]
115802163  U4 spliceosomal RNA [KO:K14278]
115803991  U4 spliceosomal RNA [KO:K14278]
115802889  U4 spliceosomal RNA [KO:K14278]
115803463  U5 spliceosomal RNA [KO:K14279]
115802782  U5 spliceosomal RNA [KO:K14279]
115802793  U5 spliceosomal RNA [KO:K14279]
115802557  U5 spliceosomal RNA [KO:K14279]
115801872  U5 spliceosomal RNA [KO:K14279]
115803883  U5 spliceosomal RNA [KO:K14279]
115802558  U6 spliceosomal RNA [KO:K14280]
115802305  U6 spliceosomal RNA [KO:K14280]
115801881  U6 spliceosomal RNA [KO:K14280]
115803658  U6 spliceosomal RNA [KO:K14280]
115803189  U6 spliceosomal RNA [KO:K14280]
115802331  U6 spliceosomal RNA [KO:K14280]
115801965  U6 spliceosomal RNA [KO:K14280]
115803816  U6 spliceosomal RNA [KO:K14280]
115804222  U6 spliceosomal RNA [KO:K14280]
115801789  U6 spliceosomal RNA [KO:K14280]
115802774  U6 spliceosomal RNA [KO:K14280]
115802711  U6 spliceosomal RNA [KO:K14280]
115801599  U6 spliceosomal RNA [KO:K14280]
115801582  U6 spliceosomal RNA [KO:K14280]
115802182  U6 spliceosomal RNA [KO:K14280]
115803333  U6 spliceosomal RNA [KO:K14280]
115801879  U6 spliceosomal RNA [KO:K14280]
115804053  U6 spliceosomal RNA [KO:K14280]
115801875  U6 spliceosomal RNA [KO:K14280]
115801651  U6 spliceosomal RNA [KO:K14280]
115803663  U6 spliceosomal RNA [KO:K14280]
115803959  U6 spliceosomal RNA [KO:K14280]
115801654  U6 spliceosomal RNA [KO:K14280]
115803500  U6 spliceosomal RNA [KO:K14280]
115803361  U6 spliceosomal RNA [KO:K14280]
115803245  U6 spliceosomal RNA [KO:K14280]
115802875  U6 spliceosomal RNA [KO:K14280]
115802173  U6 spliceosomal RNA [KO:K14280]
115803695  U6 spliceosomal RNA [KO:K14280]
115803572  U6 spliceosomal RNA [KO:K14280]
115803450  U6 spliceosomal RNA [KO:K14280]
115802885  U6 spliceosomal RNA [KO:K14280]
115803043  U6 spliceosomal RNA [KO:K14280]
115803337  U6 spliceosomal RNA [KO:K14280]
115802823  U6 spliceosomal RNA [KO:K14280]
115802069  U6 spliceosomal RNA [KO:K14280]
115802540  U6 spliceosomal RNA [KO:K14280]
115801878  U6 spliceosomal RNA [KO:K14280]
115804119  U6 spliceosomal RNA [KO:K14280]
115803661  U6 spliceosomal RNA [KO:K14280]
115803705  U6 spliceosomal RNA [KO:K14280]
115801516  U6 spliceosomal RNA [KO:K14280]
115802308  U6 spliceosomal RNA [KO:K14280]
115803673  U6 spliceosomal RNA [KO:K14280]
115801649  U6 spliceosomal RNA [KO:K14280]
115801874  U6 spliceosomal RNA [KO:K14280]
115802062  U6 spliceosomal RNA [KO:K14280]
115802059  U6 spliceosomal RNA [KO:K14280]
115801791  U6 spliceosomal RNA [KO:K14280]
115801558  U6 spliceosomal RNA [KO:K14280]
115803246  U6 spliceosomal RNA [KO:K14280]
115801799  U6 spliceosomal RNA [KO:K14280]
115803359  U6 spliceosomal RNA [KO:K14280]
115803694  U6 spliceosomal RNA [KO:K14280]
115802164  U6 spliceosomal RNA [KO:K14280]
115801967  U6 spliceosomal RNA [KO:K14280]
115804085  U6 spliceosomal RNA [KO:K14280]
115803742  U6 spliceosomal RNA [KO:K14280]
115803267  U6 spliceosomal RNA [KO:K14280]
115804199  U6 spliceosomal RNA [KO:K14280]
115801520  U6 spliceosomal RNA [KO:K14280]
115802594  U6 spliceosomal RNA [KO:K14280]
115802676  U6 spliceosomal RNA [KO:K14280]
115802601  U6 spliceosomal RNA [KO:K14280]
115802116  U6 spliceosomal RNA [KO:K14280]
115801658  U6 spliceosomal RNA [KO:K14280]
115801752  U6 spliceosomal RNA [KO:K14280]
115802598  U6 spliceosomal RNA [KO:K14280]
115803794  U6 spliceosomal RNA [KO:K14280]
115802884  U6 spliceosomal RNA [KO:K14280]
115802957  U6 spliceosomal RNA [KO:K14280]
115802642  U6 spliceosomal RNA [KO:K14280]
115801914  U6 spliceosomal RNA [KO:K14280]
111182457  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
111170655  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
111170677  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
111179565  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
111164536  CDC40; pre-mRNA-processing factor 17 isoform X1 [KO:K12816]
111178081  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
111170204  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
111185521  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
111170992  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
111184368  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
111181455  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
111180728  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
111162910  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
111184794  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
111168731  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
111167877  SNRPG; small nuclear ribonucleoprotein G isoform X1 [KO:K11099]
111180634  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
111180834  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
111178710  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
111172763  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
111174026  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
111176289  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
111176887  LOW QUALITY PROTEIN: RNA-binding protein 25-like [KO:K12822]
111182637  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
111183054  TCERG1; LOW QUALITY PROTEIN: transcription elongation regulator 1 [KO:K12824]
111182109  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
111164699  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
111185025  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
111162666  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
111166182  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
111175610  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
111171690  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
111183720  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
111179537  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
111169726  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
111166576  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
111175011  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
111186338  PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
111182613  DDX42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
111181200  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
111163808  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
111180572  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
111165100  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
111172316  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
111177979  RBM17; splicing factor 45 [KO:K12840]
111166520  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
111179273  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
111179885  retinitis pigmentosa 9 protein-like isoform X1 [KO:K19604]
111179803  RP9; retinitis pigmentosa 9 protein isoform X1 [KO:K19604]
111170689  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
111168813  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
111166678  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
111179949  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
111187730  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
111166191  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
111182416  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
111169758  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
111177305  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
111175679  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
111180995  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
111186396  SNU13; NHP2-like protein 1 isoform X1 [KO:K12845]
111167919  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
111165415  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
111183727  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
111182548  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
111175816  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
111180092  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
111170201  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
111187413  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
111186775  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
111185653  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
111175488  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
111174037  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
111167279  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
111183905  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
111178879  CDC5L; cell division cycle 5-like protein [KO:K12860]
111179997  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
111187728  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
111180280  spliceosome-associated protein CWC15 homolog [KO:K12863]
111167962  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
111184196  CTNNBL1; beta-catenin-like protein 1 isoform X1 [KO:K12864]
111170662  heat shock 70 kDa protein 1B [KO:K03283]
111170663  heat shock 70 kDa protein 1B [KO:K03283]
111170664  heat shock 70 kDa protein 1-like [KO:K03283]
111167407  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111170417  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
111169520  PQBP1; polyglutamine-binding protein 1 [KO:K12865]
111176795  WBP11; WW domain-binding protein 11 [KO:K12866]
111176204  SNW1; SNW domain-containing protein 1 [KO:K06063]
111165976  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
111163337  LOW QUALITY PROTEIN: pre-mRNA-splicing factor SYF2-like [KO:K12868]
111163395  pre-mRNA-splicing factor SYF2 [KO:K12868]
111185053  CRNKL1; crooked neck-like protein 1 [KO:K12869]
111168795  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
111178748  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
111175628  peptidyl-prolyl cis-trans isomerase E-like [KO:K09564] [EC:5.2.1.8]
111175637  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
111174456  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
111183099  RBM22; pre-mRNA-splicing factor RBM22 isoform X1 [KO:K12872]
111181921  BUD31; protein BUD31 homolog isoform X2 [KO:K12873]
111181780  AQR; RNA helicase aquarius [KO:K12874]
111164099  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
111182734  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
111179934  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
111175831  MAGOH; protein mago nashi homolog [KO:K12877]
111176760  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
111181450  THOC1; THO complex subunit 1 [KO:K12878]
111168226  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
111169854  THOC3; THO complex subunit 3 [KO:K12880]
111182691  ALYREF; THO complex subunit 4 [KO:K12881]
111187941  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
111172329  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
111165798  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
111180388  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111168823  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111171984  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111173921  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
111179872  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111172906  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
111171157  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111180501  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111172639  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111172644  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111168125  heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741]
111179862  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111177699  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111187903  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111162914  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111165679  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111165695  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111165023  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111172504  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
111181822  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
111164534  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
111166801  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
111166207  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X12 [KO:K12887]
111177551  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
111167943  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
111163765  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
111182780  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
111178742  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
111173020  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
111177240  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893]
111184163  SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
111163213  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
111174866  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
111162633  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
111173029  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
111182061  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
111163457  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

DBGET integrated database retrieval system