KEGG   PATHWAY: ebu00260
Entry
ebu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Enterobacteriaceae bacterium S05
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ebu00260  Glycine, serine and threonine metabolism
ebu00260

Module
ebu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ebu00260]
ebu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ebu00260]
ebu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ebu00260]
ebu_M00621  Glycine cleavage system [PATH:ebu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Enterobacteriaceae bacterium S05 [GN:ebu]
Gene
CUC76_14045  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
CUC76_11665  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CUC76_14945  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
CUC76_17270  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CUC76_02270  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CUC76_11660  homoserine kinase [KO:K00872] [EC:2.7.1.39]
CUC76_11655  threonine synthase [KO:K01733] [EC:4.2.3.1]
CUC76_06800  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CUC76_22015  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CUC76_05970  glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CUC76_21410  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CUC76_16575  glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CUC76_09120  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CUC76_20610  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CUC76_07545  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CUC76_11720  phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
CUC76_16340  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
CUC76_08215  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CUC76_21045  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CUC76_19550  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CUC76_06625  3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
CUC76_11760  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CUC76_03045  bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CUC76_16315  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
CUC76_16320  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
CUC76_03725  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
CUC76_19600  aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
CUC76_19590  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CUC76_10275  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CUC76_11035  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CUC76_19595  gcvH; glycine cleavage system protein H [KO:K02437]
CUC76_21840  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
CUC76_08495  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CUC76_19240  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CUC76_19235  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
CUC76_20555  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CUC76_24910  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CUC76_25135  bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB [KO:K01754] [EC:4.3.1.19]
CUC76_15700  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
CUC76_20025  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
CUC76_04420  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CUC76_04415  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CUC76_02110  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
CUC76_02105  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ebu00010  Glycolysis / Gluconeogenesis
ebu00020  Citrate cycle (TCA cycle)
ebu00230  Purine metabolism
ebu00250  Alanine, aspartate and glutamate metabolism
ebu00270  Cysteine and methionine metabolism
ebu00290  Valine, leucine and isoleucine biosynthesis
ebu00300  Lysine biosynthesis
ebu00330  Arginine and proline metabolism
ebu00460  Cyanoamino acid metabolism
ebu00470  D-Amino acid metabolism
ebu00564  Glycerophospholipid metabolism
ebu00600  Sphingolipid metabolism
ebu00620  Pyruvate metabolism
ebu00630  Glyoxylate and dicarboxylate metabolism
ebu00640  Propanoate metabolism
ebu00680  Methane metabolism
ebu00860  Porphyrin metabolism
ebu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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