KEGG   PATHWAY: efo00983
Entry
efo00983                    Pathway                                
Name
Drug metabolism - other enzymes - Epinephelus fuscoguttatus (brown-marbled grouper)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
efo00983  Drug metabolism - other enzymes
efo00983

Organism
Epinephelus fuscoguttatus (brown-marbled grouper) [GN:efo]
Gene
125887871  hprt1l; hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
125894111  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
125883059  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
125891122  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
125887356  impdh1a; inosine-5'-monophosphate dehydrogenase 1a [KO:K00088] [EC:1.1.1.205]
125888851  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
125904486  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
125885130  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125895962  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
125887381  ces2b; uncharacterized protein ces2b [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
125902059  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
125882895  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
125890088  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
125902577  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125902593  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
125902615  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
125884359  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
125890686  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
125890687  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125890783  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
125890784  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
125878678  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
125898720  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
125887163  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
125899936  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
125906304  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125880656  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
125897941  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
125882209  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
125886978  cdab; cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
125882626  thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
125902709  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
125893683  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
125889718  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
125899231  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
125893793  upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
125896095  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
125902074  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
125896913  si:ch211-243j20.2; uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
125891326  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
125891735  uckl1a; uridine-cytidine kinase-like 1a [KO:K00876] [EC:2.7.1.48]
125906346  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
125904004  tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
125886034  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
125900037  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
125902337  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
125889283  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
125898128  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
125897177  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
125897495  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
125905256  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
125895697  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
125896559  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
125878952  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
125878955  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
125879643  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
125880899  nucleoside diphosphate kinase A2-like [KO:K00940] [EC:2.7.4.6]
125898870  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
125878937  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
125878942  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
125878950  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
125902352  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
125883029  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125890807  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
125890893  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
125903281  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
125903707  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
125903708  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
125903709  glutathione S-transferase A1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
125904516  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
125891781  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
125904730  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
125886262  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
125905153  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
125894080  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
125901386  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system