KEGG   PATHWAY: exf00260
Entry
exf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Enterobacter hormaechei subsp. xiangfangensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
exf00260  Glycine, serine and threonine metabolism
exf00260

Module
exf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:exf00260]
exf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:exf00260]
exf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:exf00260]
exf_M00555  Betaine biosynthesis, choline => betaine [PATH:exf00260]
exf_M00621  Glycine cleavage system [PATH:exf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Enterobacter hormaechei subsp. xiangfangensis [GN:exf]
Gene
BFV63_01430  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BFV63_03305  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BFV63_21570  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BFV63_20600  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BFV63_03310  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BFV63_03315  threonine synthase [KO:K01733] [EC:4.2.3.1]
BFV63_07270  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BFV63_16145  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BFV63_07905  bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BFV63_01100  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BFV63_19190  glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
BFV63_17595  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BFV63_06540  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BFV63_03280  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BFV63_00750  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BFV63_18210  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BFV63_07440  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BFV63_03235  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BFV63_10305  NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BFV63_00715  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BFV63_00720  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BFV63_10415  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
BFV63_18160  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BFV63_18170  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BFV63_03775  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BFV63_18165  glycine cleavage system protein H [KO:K02437]
BFV63_16470  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BFV63_05700  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BFV63_05705  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BFV63_09450  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
BFV63_09445  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
BFV63_17655  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BFV63_13065  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BFV63_19175  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
BFV63_21380  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BFV63_00115  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BFV63_17855  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BFV63_12285  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BFV63_12280  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BFV63_14565  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BFV63_14570  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
exf00010  Glycolysis / Gluconeogenesis
exf00020  Citrate cycle (TCA cycle)
exf00230  Purine metabolism
exf00250  Alanine, aspartate and glutamate metabolism
exf00270  Cysteine and methionine metabolism
exf00290  Valine, leucine and isoleucine biosynthesis
exf00300  Lysine biosynthesis
exf00330  Arginine and proline metabolism
exf00460  Cyanoamino acid metabolism
exf00470  D-Amino acid metabolism
exf00564  Glycerophospholipid metabolism
exf00600  Sphingolipid metabolism
exf00620  Pyruvate metabolism
exf00630  Glyoxylate and dicarboxylate metabolism
exf00640  Propanoate metabolism
exf00680  Methane metabolism
exf00860  Porphyrin metabolism
exf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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