KEGG   PATHWAY: fcd00983
Entry
fcd00983                    Pathway                                
Name
Drug metabolism - other enzymes - Folsomia candida
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
fcd00983  Drug metabolism - other enzymes
fcd00983

Organism
Folsomia candida [GN:fcd]
Gene
110853127  inosine-5'-monophosphate dehydrogenase-like [KO:K00088] [EC:1.1.1.205]
110845625  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
110844198  uncharacterized protein LOC110844198 [KO:K00569] [EC:2.1.1.67]
110842136  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110859404  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110845042  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110846051  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110853954  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110845123  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110851258  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110850366  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110860745  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110850372  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110856936  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110846885  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110847755  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
110843353  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
110843494  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
110847986  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
110845627  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
110850464  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
110852203  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
110852242  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
110853241  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
110856408  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
110851934  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
110852928  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
110852938  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
110850300  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
110845448  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
110854016  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
110854376  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
110862151  UDP-glucuronosyltransferase 1-7C-like isoform X1 [KO:K00699] [EC:2.4.1.17]
110862566  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
110857699  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
110853974  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
110863041  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
110844517  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
110853054  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
110851329  uncharacterized protein LOC110851329 [KO:K01489] [EC:3.5.4.5]
110843751  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
110856813  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
110846302  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
110851048  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
110844044  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
110858338  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
110848251  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
110846296  probable uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
110854066  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
110855899  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
110850988  UMP-CMP kinase-like isoform X1 [KO:K13800] [EC:2.7.4.14]
110851853  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
110852546  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
110850769  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
110857007  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
110846788  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
110849118  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
110854828  probable deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
110856494  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110860732  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110855534  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110855537  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110856531  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110861249  uncharacterized protein LOC110861249 [KO:K01520] [EC:3.6.1.23]
110854471  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110850520  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110850557  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110858915  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
110848067  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
110853235  probable deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
110847634  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110849714  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110851810  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
110858672  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110842434  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
110861317  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
110843031  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110849846  glutathione S-transferase class-mu 26 kDa isozyme 47-like [KO:K00799] [EC:2.5.1.18]
110849857  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110843202  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110857236  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
110844243  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110846300  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110849941  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110849973  glutathione S-transferase 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110858760  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
110854586  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110854596  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110848477  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110862686  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
110851681  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110862186  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110850206  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110841837  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
110847087  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
110847118  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
110852264  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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