KEGG   PATHWAY: gab00053
Entry
gab00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Gossypium arboreum (tree cotton)
Class
Metabolism; Carbohydrate metabolism
Pathway map
gab00053  Ascorbate and aldarate metabolism
gab00053

Module
gab_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:gab00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Gossypium arboreum (tree cotton) [GN:gab]
Gene
108479563  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
108483727  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
108479786  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
108487526  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
108473554  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
108461820  UDP-glucose 6-dehydrogenase 1 isoform X1 [KO:K00012] [EC:1.1.1.22]
108467534  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
108462975  UDP-sugar pyrophosphorylase-like isoform X1 [KO:K12447] [EC:2.7.7.64]
108454400  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
108477720  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
108482160  probable inositol oxygenase isoform X1 [KO:K00469] [EC:1.13.99.1]
108487319  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
108485480  inositol oxygenase 2 isoform X1 [KO:K00469] [EC:1.13.99.1]
108450760  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
108460560  aldo-keto reductase family 4 member C9-like [KO:K00002] [EC:1.1.1.2]
108480021  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
108482739  aldo-keto reductase family 4 member C9 [KO:K00002] [EC:1.1.1.2]
108476403  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
108462918  aldose reductase [KO:K00002] [EC:1.1.1.2]
108456068  aldo-keto reductase family 4 member C9-like [KO:K00002] [EC:1.1.1.2]
108472509  aldo-keto reductase family 4 member C8-like [KO:K00002] [EC:1.1.1.2]
108474545  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
108459365  aldo-keto reductase family 4 member C9-like [KO:K00002] [EC:1.1.1.2]
108460556  aldo-keto reductase family 4 member C9-like isoform X1 [KO:K00002] [EC:1.1.1.2]
108460557  aldo-keto reductase family 4 member C9-like [KO:K00002] [EC:1.1.1.2]
108457895  aldo-keto reductase family 4 member C9-like [KO:K00002] [EC:1.1.1.2]
108472389  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
108478560  probable L-gulonolactone oxidase 6 isoform X1 [KO:K00103] [EC:1.1.3.8]
108470172  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
108464468  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
108482914  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
108452928  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
108464116  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
108453343  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
108453651  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
108460500  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
108474730  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
108479971  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
108473872  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
108483364  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
108468077  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
108476084  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
108469295  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
108482147  LOW QUALITY PROTEIN: UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
108487026  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
108470031  UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
108457841  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
108465377  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
108466572  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
108488709  D-galacturonate reductase-like isoform X1 [KO:K19642] [EC:1.1.1.365]
108467230  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
108488427  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
108457017  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
108489653  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
108489855  monodehydroascorbate reductase 5, mitochondrial [KO:K08232] [EC:1.6.5.4]
108464012  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
108486104  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
108467585  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
108470238  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
108484599  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
108489681  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
108475956  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
108467715  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
108488538  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
108463433  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
108453402  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
108453752  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
108480636  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
108470682  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
108458125  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
108469892  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
108452553  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108466852  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108487771  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108451244  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108452650  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108452667  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108452670  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108452686  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108464786  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
108479632  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
108470750  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
108466978  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
108474904  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
108477187  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
108452532  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
108458013  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
108486541  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
108454985  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
108465053  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
108473666  aldehyde dehydrogenase family 7 member B4 isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
gab00020  Citrate cycle (TCA cycle)
gab00040  Pentose and glucuronate interconversions
gab00051  Fructose and mannose metabolism
gab00520  Amino sugar and nucleotide sugar metabolism
gab00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

DBGET integrated database retrieval system