KEGG   PATHWAY: gat00983
Entry
gat00983                    Pathway                                
Name
Drug metabolism - other enzymes - Gasterosteus aculeatus (three-spined stickleback)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
gat00983  Drug metabolism - other enzymes
gat00983

Organism
Gasterosteus aculeatus (three-spined stickleback) [GN:gat]
Gene
120818270  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
120809752  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
120829320  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
120817166  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
120808779  inosine-5'-monophosphate dehydrogenase 1a-like isoform X1 [KO:K00088] [EC:1.1.1.205]
120812608  inosine-5'-monophosphate dehydrogenase 1a-like isoform X1 [KO:K00088] [EC:1.1.1.205]
120828039  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
120826327  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
120817414  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120824166  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
120833860  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
120833874  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
120833886  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
120816255  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
120830157  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
120830378  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
120808586  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
120819012  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
120810740  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
120822215  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
120822216  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
120822381  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 isoform X1 [KO:K00699] [EC:2.4.1.17]
120821344  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
120835280  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
120822540  zgc:103586 [KO:K01489] [EC:3.5.4.5]
120818389  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
120816280  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
120811164  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
120830357  upb1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
120833553  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
120810653  upp1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
120831511  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
120823523  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
120808060  si:ch211-243j20.2; uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
120828769  uckl1a; LOW QUALITY PROTEIN: uridine-cytidine kinase-like 1a [KO:K00876] [EC:2.7.1.48]
120815099  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
120815100  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
120815652  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
120824820  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
120820370  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
120834183  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
120815853  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
120808701  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
120822018  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
120826239  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
120815243  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120815250  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120808126  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
120824047  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120819550  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
120827514  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
120827933  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
120812157  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
120834089  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
120812918  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
120833227  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
120829361  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
120829505  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
120830179  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
120817966  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120820309  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
120820561  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120820562  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
120827097  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
120827098  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
120827100  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
120827101  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
120827102  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
120827103  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
120815709  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system