Entry Name Homologous recombination - Gallus gallus (chicken)
Description Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class Genetic Information Processing; Replication and repairBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Gallus gallus (chicken) [GN:
gga ]
Gene 418122 SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111 ]
416329 RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866 ] [EC:3.6.-.-]
395555 MRE11; double-strand break repair protein MRE11 [KO:K10865 ]
424010 BARD1; BRCA1-associated RING domain protein 1 [KO:K10683 ]
421071 RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773 ] [EC:3.1.-.-]
420694 TOPBP1; DNA topoisomerase 2-binding protein 1 [KO:K10728 ]
776677 BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 [KO:K20776 ]
421417 BABAM2; BRISC and BRCA1-A complex member 2 [KO:K12173 ]
422201 BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864 ] [EC:3.4.19.-]
416572 PALB2; partner and localizer of BRCA2 isoform X1 [KO:K10897 ]
374139 BRCA2; breast cancer type 2 susceptibility protein [KO:K08775 ]
772237 SEM1; 26S proteasome complex subunit SEM1 [KO:K10881 ]
418097 SYCP3; synaptonemal complex protein 3 isoform X1 [KO:K19528 ]
417563 RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
419566 RPA4; replication protein A 32 kDa subunit [KO:K10739 ]
420578 RPA3; replication protein A 14 kDa subunit [KO:K10740 ]
396086 RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482 ]
418152 RAD52; DNA repair protein RAD52 homolog isoform 2 [KO:K10873 ]
769071 RAD51B; DNA repair protein RAD51 homolog 2 [KO:K10869 ]
417626 RAD51C; DNA repair protein RAD51 homolog 3 isoform X2 [KO:K10870 ]
417528 RAD51D; DNA repair protein RAD51 homolog 4 [KO:K10871 ]
424611 RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875 ] [EC:5.6.2.-]
395449 RAD54B; DNA repair and recombination protein RAD54B [KO:K10877 ] [EC:5.6.2.-]
101748102 MUS81; crossover junction endonuclease MUS81 [KO:K08991 ] [EC:3.1.22.-]
422104 EME1; crossover junction endonuclease EME1 isoform X3 [KO:K10882 ] [EC:3.1.22.-]
Reference Authors Maloisel L, Fabre F, Gangloff S.
Title DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal Reference Authors Haruta-Takahashi N, Iwasaki H.
Title [Recombination mediators]
Journal Seikagaku 79:449-53 (2007)
Reference Authors Ouyang KJ, Woo LL, Ellis NA.
Title Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal Reference Authors Kawabata M, Kawabata T, Nishibori M.
Title Role of recA/RAD51 family proteins in mammals.
Journal Reference Authors Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title Mitotic recombination in Saccharomyces cerevisiae.
Journal Reference Authors Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title Rad54: the Swiss Army knife of homologous recombination?
Journal Reference Authors Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title Recombination proteins and rescue of arrested replication forks.
Journal KO pathway LinkDB All DBs
