KEGG   PATHWAY: gmg00260
Entry
gmg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Gordonia mangrovi
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
gmg00260  Glycine, serine and threonine metabolism
gmg00260

Module
gmg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:gmg00260]
gmg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:gmg00260]
gmg_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:gmg00260]
gmg_M00621  Glycine cleavage system [PATH:gmg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Gordonia mangrovi [GN:gmg]
Gene
NWF22_08415  aspartate kinase [KO:K00928] [EC:2.7.2.4]
NWF22_08410  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NWF22_19580  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NWF22_19590  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
NWF22_19585  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
NWF22_07090  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NWF22_18645  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NWF22_19620  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NWF22_00375  glycerate kinase [KO:K00865] [EC:2.7.1.165]
NWF22_05820  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
NWF22_01145  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NWF22_17035  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
NWF22_01395  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
NWF22_20105  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
NWF22_19945  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
NWF22_23410  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NWF22_00400  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
NWF22_13900  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NWF22_23440  gcvH; glycine cleavage system protein GcvH [KO:K02437]
NWF22_13680  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
NWF22_05895  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
NWF22_14925  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NWF22_15150  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
NWF22_19030  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NWF22_07005  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
NWF22_10530  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
NWF22_07000  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
NWF22_10525  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
NWF22_10500  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
NWF22_10515  sarcosine oxidase subunit delta [KO:K00302] [EC:1.5.3.24 1.5.3.1]
NWF22_10520  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
NWF22_18460  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
NWF22_18470  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
NWF22_18950  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NWF22_24440  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
NWF22_24235  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
NWF22_24240  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
NWF22_08655  TrpB-like pyridoxal phosphate-dependent enzyme [KO:K06001] [EC:4.2.1.20]
NWF22_20415  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
NWF22_20420  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
NWF22_20410  ectoine synthase [KO:K06720] [EC:4.2.1.108]
NWF22_07170  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
NWF22_06865  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
gmg00010  Glycolysis / Gluconeogenesis
gmg00020  Citrate cycle (TCA cycle)
gmg00230  Purine metabolism
gmg00250  Alanine, aspartate and glutamate metabolism
gmg00270  Cysteine and methionine metabolism
gmg00290  Valine, leucine and isoleucine biosynthesis
gmg00300  Lysine biosynthesis
gmg00330  Arginine and proline metabolism
gmg00460  Cyanoamino acid metabolism
gmg00470  D-Amino acid metabolism
gmg00564  Glycerophospholipid metabolism
gmg00600  Sphingolipid metabolism
gmg00620  Pyruvate metabolism
gmg00630  Glyoxylate and dicarboxylate metabolism
gmg00640  Propanoate metabolism
gmg00680  Methane metabolism
gmg00860  Porphyrin metabolism
gmg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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