KEGG   PATHWAY: gra00053
Entry
gra00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Gossypium raimondii
Class
Metabolism; Carbohydrate metabolism
Pathway map
gra00053  Ascorbate and aldarate metabolism
gra00053

Module
gra_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:gra00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Gossypium raimondii [GN:gra]
Gene
105788243  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
105794230  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
105764476  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
105784316  UDP-glucose 6-dehydrogenase 1 isoform X1 [KO:K00012] [EC:1.1.1.22]
105802497  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
105763587  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
105792654  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
105783427  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
105798370  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
105789362  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
105765001  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
105776823  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
105774597  inositol oxygenase 4 isoform X1 [KO:K00469] [EC:1.13.99.1]
105770584  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
105762494  LOW QUALITY PROTEIN: inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
105779423  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
105782346  aldose reductase isoform X1 [KO:K00002] [EC:1.1.1.2]
105799827  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
105761840  aldo-keto reductase family 4 member C8 [KO:K00002] [EC:1.1.1.2]
105779420  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
105779421  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
105779422  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
105764409  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
105789859  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
105794302  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
105785113  aldose reductase-like [KO:K00002] [EC:1.1.1.2]
105763150  L-gulonolactone oxidase 3 isoform X1 [KO:K00103] [EC:1.1.3.8]
105763957  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
105792573  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
105783228  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
105781073  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
105768479  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
105782389  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
105769546  inositol-phosphate phosphatase isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
105776961  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
105795327  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
105763009  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
105761589  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
105797592  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
105790333  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
105792829  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
105791651  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
105792115  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
105796487  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
105779570  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
105777239  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
105802593  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
105804054  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
105794339  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
105786356  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
105765259  monodehydroascorbate reductase, chloroplastic/mitochondrial [KO:K08232] [EC:1.6.5.4]
105782180  monodehydroascorbate reductase, seedling isozyme isoform X1 [KO:K08232] [EC:1.6.5.4]
105776449  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
105799692  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
105798324  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
105785908  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
105787462  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
105792368  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105792370  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105792371  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105795404  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
105772729  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
105781150  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105773990  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
105767858  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
105769825  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
105769872  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105776802  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
105780418  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
105789278  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
105785652  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105793576  LOW QUALITY PROTEIN: L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105783514  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105783515  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105783516  LOW QUALITY PROTEIN: L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105783517  LOW QUALITY PROTEIN: L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105792378  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
128035909  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
105768632  benzaldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
105787498  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
105764264  benzaldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
105765714  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
105779810  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
105773428  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
105771253  aldehyde dehydrogenase family 3 member H1 isoform X1 [KO:K00128] [EC:1.2.1.3]
105768765  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
105797162  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
105773235  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
gra00020  Citrate cycle (TCA cycle)
gra00040  Pentose and glucuronate interconversions
gra00051  Fructose and mannose metabolism
gra00520  Amino sugar and nucleotide sugar metabolism
gra00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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