KEGG   PATHWAY: gsh00983
Entry
gsh00983                    Pathway                                
Name
Drug metabolism - other enzymes - Geotrypetes seraphini (Gaboon caecilian)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
gsh00983  Drug metabolism - other enzymes
gsh00983

Organism
Geotrypetes seraphini (Gaboon caecilian) [GN:gsh]
Gene
117360473  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
117351181  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
117366882  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
117366775  GMPS; LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
117355675  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
117357867  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117367919  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
117369117  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
117349154  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
117349108  CDA; cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
117367093  TYMP; thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
117346354  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
117355911  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
117366007  UPB1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
117353921  UPP1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
117356931  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
117368986  UCKL1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
117367786  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
117368476  UCK2; uridine-cytidine kinase 2 isoform X1 [KO:K00876] [EC:2.7.1.48]
117359927  TK2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
117367486  TK1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
117360303  UMPS; uridine 5'-monophosphate synthase isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
117346540  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
117362591  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
117358014  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
117355939  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
117353652  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
117345797  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
117345863  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
117359382  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
117360496  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
117366580  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
117368305  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
117353707  probable deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
117347988  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
117362952  uncharacterized protein LOC117362952 [KO:K01520] [EC:3.6.1.23]
117357287  probable deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
117364220  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
117367561  uncharacterized protein LOC117367561 [KO:K01520] [EC:3.6.1.23]
117349196  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
117359629  NAT1; arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
117352686  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
117347504  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
117345790  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
117363293  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
117357414  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
117358046  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
117364422  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
117364495  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
117359622  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
117359623  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
117368092  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
117348114  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
117348351  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
117348632  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
117348633  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
117348634  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
117348635  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
117348695  glutathione S-transferase P 1-like isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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