KEGG   PATHWAY: han00053
Entry
han00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Helianthus annuus (common sunflower)
Class
Metabolism; Carbohydrate metabolism
Pathway map
han00053  Ascorbate and aldarate metabolism
han00053

Module
han_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:han00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Helianthus annuus (common sunflower) [GN:han]
Gene
110903910  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
110917291  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
110911055  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
110921944  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
110936167  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
118480454  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
118484944  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
110904244  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
110927044  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
110922084  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
110921215  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
110864941  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
110899790  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
110936771  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
110936772  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
110898831  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
110884431  aldose reductase [KO:K00002] [EC:1.1.1.2]
110926078  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
110920939  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
110918634  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
110937996  NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
110883880  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
110900985  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
110879631  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
110874959  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
110879630  LOW QUALITY PROTEIN: probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
110900140  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
110930994  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
110873602  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
110910786  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
110942108  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
110923354  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
110923355  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
110918067  inositol-phosphate phosphatase [KO:K10047] [EC:3.1.3.25 3.1.3.93]
110929164  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
110877998  L-galactose dehydrogenase isoform X1 [KO:K17744] [EC:1.1.1.316]
110897681  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
110928921  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
110920853  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
110908559  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
110915639  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
110931105  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
110902246  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
110917666  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
110920258  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
110900281  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
110927277  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
110940374  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
110872872  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
110872873  D-galacturonate reductase-like isoform X1 [KO:K19642] [EC:1.1.1.365]
110872885  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
110872886  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
110870024  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
110894612  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
110894613  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
110894616  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
110894617  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
110868650  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
110904060  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
110895508  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
110930440  monodehydroascorbate reductase, chloroplastic/mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
110911227  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
110898546  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
110926092  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
110911573  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
110871293  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110911973  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
110918963  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110941205  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
110939906  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110888227  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110893651  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110872537  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110896725  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110909251  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110933878  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110912888  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
110908650  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
110890477  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
110868532  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
110868356  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
110889475  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
110904044  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
110904045  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
110879822  aldehyde dehydrogenase family 2 member B4, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
110879823  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
110907491  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
110927106  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
110916468  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
110941206  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
110886479  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
han00020  Citrate cycle (TCA cycle)
han00040  Pentose and glucuronate interconversions
han00051  Fructose and mannose metabolism
han00520  Amino sugar and nucleotide sugar metabolism
han00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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