KEGG   PATHWAY: hbr00053
Entry
hbr00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Hevea brasiliensis (rubber tree)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hbr00053  Ascorbate and aldarate metabolism
hbr00053

Module
hbr_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:hbr00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Hevea brasiliensis (rubber tree) [GN:hbr]
Gene
110663391  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
110657719  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
110656940  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
110659354  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
110635347  UDP-glucose 6-dehydrogenase 1-like isoform X1 [KO:K00012] [EC:1.1.1.22]
110636249  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
110647558  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
110632622  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
110648530  glucuronokinase 1-like isoform X1 [KO:K16190] [EC:2.7.1.43]
110657734  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
110659960  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
110649813  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
110659157  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
110662448  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110662449  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
110662450  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110658264  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110658289  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110656657  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110656658  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110656660  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110664464  LOW QUALITY PROTEIN: aldose reductase [KO:K00002] [EC:1.1.1.2]
110662415  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
110667924  L-gulonolactone oxidase 3 isoform X1 [KO:K00103] [EC:1.1.3.8]
110661050  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
110672771  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
110662568  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
110671312  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
110648686  GDP-mannose 3,5-epimerase 2-like isoform X1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
110652441  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
110669975  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
110673415  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
110652492  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
110670426  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
110648027  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
110664496  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
110667092  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
110657808  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
110661187  L-galactose dehydrogenase-like isoform X1 [KO:K17744] [EC:1.1.1.316]
110646467  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
110646472  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
110672781  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
110656223  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
110672878  UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
110672883  LOW QUALITY PROTEIN: UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
110669646  UDP-glucuronate 4-epimerase 2-like [KO:K08679] [EC:5.1.3.6]
110670209  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
110645042  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
110655634  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
110657114  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
110671659  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
110634149  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
110669250  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
110646618  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
110652056  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
110635548  monodehydroascorbate reductase, seedling isozyme [KO:K08232] [EC:1.6.5.4]
110641312  monodehydroascorbate reductase 4, peroxisomal-like isoform X1 [KO:K08232] [EC:1.6.5.4]
110636587  monodehydroascorbate reductase 5, mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
110649030  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
110652554  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
110657885  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
110652862  L-ascorbate peroxidase, cytosolic-like isoform X1 [KO:K00434] [EC:1.11.1.11]
110663897  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
110633839  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
110641765  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
110634700  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110664808  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110671418  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110663890  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110673626  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
110673636  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
110657171  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
110632265  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
110655352  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
110660465  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
110668501  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
110633798  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
110637649  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
110639005  aldehyde dehydrogenase family 3 member F1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
110640566  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
110635343  aldehyde dehydrogenase family 2 member B7, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
110664616  aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110634279  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
hbr00020  Citrate cycle (TCA cycle)
hbr00040  Pentose and glucuronate interconversions
hbr00051  Fructose and mannose metabolism
hbr00520  Amino sugar and nucleotide sugar metabolism
hbr00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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