KEGG   PATHWAY: hfr02024
Entry
hfr02024                    Pathway                                
Name
Quorum sensing - Herbaspirillum frisingense
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
hfr02024  Quorum sensing
hfr02024

Other DBs
GO: 0009372
Organism
Herbaspirillum frisingense [GN:hfr]
Gene
G5S34_13750  hypothetical protein [KO:K03666]
G5S34_15770  hfq; RNA chaperone Hfq [KO:K03666]
G5S34_21230  anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
G5S34_21235  aminodeoxychorismate/anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
G5S34_24855  HAMP domain-containing histidine kinase [KO:K07711] [EC:2.7.13.3]
G5S34_24845  response regulator [KO:K07715]
G5S34_15985  flhD; flagellar transcriptional regulator FlhD [KO:K02403]
G5S34_15980  flhC; flagellar transcriptional regulator FlhC [KO:K02402]
G5S34_20580  response regulator [KO:K07667]
G5S34_01710  ABC transporter substrate-binding protein [KO:K02055]
G5S34_03215  extracellular solute-binding protein [KO:K02055]
G5S34_04840  ABC transporter substrate-binding protein [KO:K02055]
G5S34_05395  ABC transporter substrate-binding protein [KO:K02055]
G5S34_05825  ABC transporter substrate-binding protein [KO:K02055]
G5S34_12915  ABC transporter substrate-binding protein [KO:K02055]
G5S34_01690  ABC transporter permease [KO:K02053]
G5S34_03220  ABC transporter permease [KO:K02053]
G5S34_03225  ABC transporter permease subunit [KO:K02053]
G5S34_05385  ABC transporter permease [KO:K02053]
G5S34_05795  ABC transporter permease [KO:K02053]
G5S34_12925  ABC transporter permease [KO:K02053]
G5S34_23695  ABC transporter permease subunit [KO:K02053 K02054]
G5S34_01685  ABC transporter permease [KO:K02054]
G5S34_05390  ABC transporter permease [KO:K02054]
G5S34_05790  ABC transporter permease [KO:K02054]
G5S34_12920  ABC transporter permease [KO:K02054]
G5S34_01680  ABC transporter ATP-binding protein [KO:K02052]
G5S34_03230  ABC transporter ATP-binding protein [KO:K02052]
G5S34_05400  ABC transporter ATP-binding protein [KO:K02052]
G5S34_12930  ABC transporter ATP-binding protein [KO:K02052]
G5S34_23700  ABC transporter ATP-binding protein [KO:K02052]
G5S34_00740  ABC transporter substrate-binding protein [KO:K01999]
G5S34_00870  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_02925  ABC transporter substrate-binding protein [KO:K01999]
G5S34_03010  ABC transporter substrate-binding protein [KO:K01999]
G5S34_03925  ABC transporter substrate-binding protein [KO:K01999]
G5S34_05060  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_06870  ABC transporter substrate-binding protein [KO:K01999]
G5S34_06975  ABC transporter substrate-binding protein [KO:K01999]
G5S34_09020  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_09050  ABC transporter substrate-binding protein [KO:K01999]
G5S34_09230  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_09845  ABC transporter substrate-binding protein [KO:K01999]
G5S34_13065  ABC transporter substrate-binding protein [KO:K01999]
G5S34_13700  ABC transporter substrate-binding protein [KO:K01999]
G5S34_14200  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_15635  ABC transporter substrate-binding protein [KO:K01999]
G5S34_16295  ABC transporter substrate-binding protein [KO:K01999]
G5S34_16430  ABC transporter substrate-binding protein [KO:K01999]
G5S34_18890  ABC transporter substrate-binding protein [KO:K01999]
G5S34_19025  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_19760  ABC transporter substrate-binding protein [KO:K01999]
G5S34_20635  ABC transporter substrate-binding protein [KO:K01999]
G5S34_21490  ABC transporter substrate-binding protein [KO:K01999]
G5S34_21745  ABC transporter substrate-binding protein [KO:K01999]
G5S34_21775  ABC transporter substrate-binding protein [KO:K01999]
G5S34_22115  ABC transporter substrate-binding protein [KO:K01999]
G5S34_22370  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
G5S34_24365  ABC transporter substrate-binding protein [KO:K01999]
G5S34_25135  ABC transporter substrate-binding protein [KO:K01999]
G5S34_00885  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_02930  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_03015  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_06065  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_06875  ABC transporter permease [KO:K01997 K01998]
G5S34_06980  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_09235  livH; high-affinity branched-chain amino acid ABC transporter permease LivH [KO:K01997]
G5S34_09850  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_12250  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_13060  ABC transporter permease [KO:K01997 K01998]
G5S34_13710  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_15640  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_18895  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_19755  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_20630  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_21715  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_21780  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_24370  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_25130  branched-chain amino acid ABC transporter permease [KO:K01997]
G5S34_18900  ATP-binding cassette domain-containing protein [KO:K01995 K01996 K01998]
G5S34_20625  ATP-binding cassette domain-containing protein [KO:K01995 K01996 K01998]
G5S34_00890  ABC transporter ATP-binding protein [KO:K01998]
G5S34_02935  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_03020  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_06070  ABC transporter ATP-binding protein [KO:K01998]
G5S34_06985  branched-chain amino acid ABC transporter ATP-binding protein/permease [KO:K01995 K01998]
G5S34_09240  high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998]
G5S34_09855  branched-chain amino acid ABC transporter ATP-binding protein/permease [KO:K01995 K01998]
G5S34_12255  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_13705  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_15645  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_19750  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_21710  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_21785  branched-chain amino acid ABC transporter ATP-binding protein/permease [KO:K01995 K01998]
G5S34_22100  branched-chain amino acid ABC transporter ATP-binding protein/permease [KO:K01995 K01998]
G5S34_24375  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_25125  branched-chain amino acid ABC transporter permease [KO:K01998]
G5S34_00895  ABC transporter ATP-binding protein [KO:K01995]
G5S34_02940  ABC transporter ATP-binding protein [KO:K01995]
G5S34_03025  ABC transporter ATP-binding protein [KO:K01995]
G5S34_06075  ABC transporter ATP-binding protein [KO:K01995]
G5S34_06880  ABC transporter ATP-binding protein [KO:K01995]
G5S34_09245  ABC transporter ATP-binding protein [KO:K01995]
G5S34_12260  ABC transporter ATP-binding protein [KO:K01995]
G5S34_13055  ABC transporter ATP-binding protein [KO:K01995]
G5S34_13715  ABC transporter ATP-binding protein [KO:K01995]
G5S34_15650  ABC transporter ATP-binding protein [KO:K01995]
G5S34_19745  ABC transporter ATP-binding protein [KO:K01995]
G5S34_21705  ABC transporter ATP-binding protein [KO:K01995]
G5S34_24380  ABC transporter ATP-binding protein [KO:K01995]
G5S34_25145  ABC transporter ATP-binding protein [KO:K01995]
G5S34_00900  ABC transporter ATP-binding protein [KO:K01996]
G5S34_02945  ABC transporter ATP-binding protein [KO:K01996]
G5S34_03030  ABC transporter ATP-binding protein [KO:K01996]
G5S34_06080  ABC transporter ATP-binding protein [KO:K01996]
G5S34_06885  ABC transporter ATP-binding protein [KO:K01996]
G5S34_06990  ABC transporter ATP-binding protein [KO:K01996]
G5S34_09250  ABC transporter ATP-binding protein [KO:K01996]
G5S34_09860  ABC transporter ATP-binding protein [KO:K01996]
G5S34_12265  ABC transporter ATP-binding protein [KO:K01996]
G5S34_13050  ABC transporter ATP-binding protein [KO:K01996]
G5S34_13695  ABC transporter ATP-binding protein [KO:K01996]
G5S34_15655  ABC transporter ATP-binding protein [KO:K01996]
G5S34_19740  ABC transporter ATP-binding protein [KO:K01996]
G5S34_21700  ABC transporter ATP-binding protein [KO:K01996]
G5S34_21790  ABC transporter ATP-binding protein [KO:K01996]
G5S34_24385  ABC transporter ATP-binding protein [KO:K01996]
G5S34_25140  ABC transporter ATP-binding protein [KO:K01996]
G5S34_06500  DUF4347 domain-containing protein [KO:K20276]
G5S34_20210  LysM peptidoglycan-binding domain-containing protein [KO:K20276]
G5S34_13720  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
G5S34_21070  long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
G5S34_06325  response regulator [KO:K13815]
G5S34_13725  Crp/Fnr family transcriptional regulator [KO:K10914]
G5S34_24615  Crp/Fnr family transcriptional regulator [KO:K10914]
G5S34_25025  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
G5S34_19695  ribD; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
G5S34_02420  adeC; AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor [KO:K18139]
G5S34_05745  efflux transporter outer membrane subunit [KO:K18139]
G5S34_10050  efflux transporter outer membrane subunit [KO:K18139]
G5S34_18930  efflux transporter outer membrane subunit [KO:K18139]
G5S34_24135  efflux transporter outer membrane subunit [KO:K18139]
G5S34_05640  ABC transporter substrate-binding protein [KO:K02035]
G5S34_07935  ABC transporter substrate-binding protein [KO:K02035]
G5S34_08465  ABC transporter substrate-binding protein [KO:K02035]
G5S34_08835  ABC transporter substrate-binding protein [KO:K02035]
G5S34_10205  peptide ABC transporter substrate-binding protein [KO:K02035]
G5S34_12740  ABC transporter substrate-binding protein [KO:K02035]
G5S34_12850  ABC transporter substrate-binding protein [KO:K02035]
G5S34_14995  ABC transporter substrate-binding protein [KO:K02035]
G5S34_17010  ABC transporter substrate-binding protein [KO:K02035]
G5S34_24680  ABC transporter substrate-binding protein [KO:K02035]
G5S34_05645  ABC transporter permease [KO:K02033]
G5S34_08470  ABC transporter permease [KO:K02033]
G5S34_08815  ABC transporter permease [KO:K02033]
G5S34_10200  ABC transporter permease [KO:K02033]
G5S34_12745  ABC transporter permease [KO:K02033]
G5S34_14985  ABC transporter permease [KO:K02033]
G5S34_17005  ABC transporter permease [KO:K02033]
G5S34_05650  ABC transporter permease [KO:K02034]
G5S34_07920  ABC transporter permease [KO:K02034]
G5S34_08475  ABC transporter permease [KO:K02034]
G5S34_08820  ABC transporter permease [KO:K02034]
G5S34_10195  ABC transporter permease [KO:K02034]
G5S34_12750  ABC transporter permease [KO:K02034]
G5S34_14980  ABC transporter permease [KO:K02034]
G5S34_17000  ABC transporter permease [KO:K02034]
G5S34_24670  ABC transporter permease [KO:K02034]
G5S34_05655  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5S34_08480  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5S34_08825  ABC transporter ATP-binding protein [KO:K02031]
G5S34_10190  ABC transporter ATP-binding protein [KO:K02031]
G5S34_12760  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5S34_14975  ABC transporter ATP-binding protein [KO:K02031]
G5S34_16995  ABC transporter ATP-binding protein [KO:K02031]
G5S34_08830  ATP-binding cassette domain-containing protein [KO:K02032]
G5S34_14970  ATP-binding cassette domain-containing protein [KO:K02032]
G5S34_16990  ABC transporter ATP-binding protein [KO:K02032]
G5S34_10185  ATP-binding cassette domain-containing protein [KO:K02032]
G5S34_23115  yidC; membrane protein insertase YidC [KO:K03217]
G5S34_00495  secE; preprotein translocase subunit SecE [KO:K03073]
G5S34_09745  secG; preprotein translocase subunit SecG [KO:K03075]
G5S34_00670  secY; preprotein translocase subunit SecY [KO:K03076]
G5S34_06340  yajC; preprotein translocase subunit YajC [KO:K03210]
G5S34_01605  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
G5S34_22230  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
G5S34_00805  secB; protein-export chaperone SecB [KO:K03071]
G5S34_01780  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
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Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
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Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
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Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
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Quinolones: from antibiotics to autoinducers.
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FEMS Microbiol Rev 35:247-74 (2011)
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Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
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Related
pathway
hfr02040  Flagellar assembly
KO pathway
ko02024   
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