KEGG   PATHWAY: hoc00983
Entry
hoc00983                    Pathway                                
Name
Drug metabolism - other enzymes - Hemiscyllium ocellatum (epaulette shark)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
hoc00983  Drug metabolism - other enzymes
hoc00983

Organism
Hemiscyllium ocellatum (epaulette shark) [GN:hoc]
Gene
132823638  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
132820078  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
132822202  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
132826688  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
132821890  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
132832198  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
132832216  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
132835115  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132822947  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132822962  uncharacterized protein LOC132822962 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132818667  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
132823626  carboxylesterase 5A-like isoform X1 [KO:K01044] [EC:3.1.1.1]
132823858  ces2b; fatty acyl-CoA hydrolase precursor, medium chain [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
132834365  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
132834366  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
132834154  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
132834155  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
132834187  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
132834188  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
132834189  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
132834242  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
132823138  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
132814027  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
132825160  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
132817239  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
132817240  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
132830521  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
132831140  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
132826872  tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
132819159  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
132815209  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
132827419  upb1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
132832236  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
132817352  LOW QUALITY PROTEIN: uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
132836075  uridine-cytidine kinase 2-A-like isoform X1 [KO:K00876] [EC:2.7.1.48]
132833452  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
132822749  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
132818669  uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
132823861  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
132827772  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
132817460  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
132819086  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
132816590  rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
132829831  rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
132807804  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
132819317  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
132825128  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
132825422  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
132827732  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
132821066  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
132834788  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
132826407  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like isoform X1 [KO:K00622] [EC:2.3.1.5]
132827046  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132829904  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
132833223  mgst2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
132807401  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
132818671  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
132813061  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132824015  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
132824046  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
132827216  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132827217  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
132827218  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132827220  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
132827254  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132827264  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
132827417  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
132827430  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
132828148  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
132826330  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
132826773  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
132826774  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
132808834  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
132808840  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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