KEGG   PATHWAY: hsyr00053
Entry
hsyr00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Hibiscus syriacus (Rose-of-Sharon)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsyr00053  Ascorbate and aldarate metabolism
hsyr00053

Module
hsyr_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:hsyr00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Hibiscus syriacus (Rose-of-Sharon) [GN:hsyr]
Gene
120130880  UDP-glucose 6-dehydrogenase 2-like [KO:K00012] [EC:1.1.1.22]
120132887  UDP-glucose 6-dehydrogenase 2-like [KO:K00012] [EC:1.1.1.22]
120118193  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
120184353  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
120203767  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
120170526  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
120122877  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
120156415  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
120140837  UDP-glucose 6-dehydrogenase 2-like [KO:K00012] [EC:1.1.1.22]
120208391  UDP-glucose 6-dehydrogenase 2-like [KO:K00012] [EC:1.1.1.22]
120193435  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
120207178  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
120136491  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
120123625  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
120123687  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
120131413  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
120186224  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
120203744  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
120154651  LOW QUALITY PROTEIN: inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
120121967  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
120192310  inositol oxygenase 2-like isoform X1 [KO:K00469] [EC:1.13.99.1]
120193492  probable inositol oxygenase isoform X1 [KO:K00469] [EC:1.13.99.1]
120150858  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
120150998  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120202826  aldo-keto reductase family 4 member C8-like [KO:K00002] [EC:1.1.1.2]
120137381  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120203741  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
120121965  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
120143165  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120128777  aldose reductase [KO:K00002] [EC:1.1.1.2]
120137272  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120142427  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120188171  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120215170  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
120207121  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
120192889  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
120127291  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
120114866  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
120211969  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
120113854  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
120150411  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
120183126  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
120154233  GDP-mannose 3,5-epimerase 2-like isoform X1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
120196346  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
120116020  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
120200491  GDP-L-galactose phosphorylase 1-like isoform X1 [KO:K14190] [EC:2.7.7.69]
120202428  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
120205265  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
120123276  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
120141555  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
120208968  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
120126589  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
120160188  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
120145353  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
120190308  inositol-phosphate phosphatase-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
120191338  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
120194598  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
120214810  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
120175431  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
120197796  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
120123656  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
120190283  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
120209732  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
120187773  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
120157993  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
120129633  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120214278  LOW QUALITY PROTEIN: UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
120199575  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120215522  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120201377  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
120218202  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
120136024  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
120136680  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120171984  UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
120188915  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120140060  UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
120141088  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120157892  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120173965  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120208426  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120192649  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
120161149  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
120128290  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
120161916  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
120124831  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
120114401  monodehydroascorbate reductase, chloroplastic/mitochondrial-like [KO:K08232] [EC:1.6.5.4]
120181812  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
120200844  monodehydroascorbate reductase, seedling isozyme [KO:K08232] [EC:1.6.5.4]
120185565  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
120136482  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
120122443  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
120159485  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
120192875  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
120193724  monodehydroascorbate reductase, chloroplastic/mitochondrial-like [KO:K08232] [EC:1.6.5.4]
120196143  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
120131431  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
120180125  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
120148287  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
120215348  L-ascorbate peroxidase, cytosolic-like isoform X1 [KO:K00434] [EC:1.11.1.11]
120216192  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
120184814  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
120154056  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
120139822  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
120141606  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
120192198  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
120193889  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
120145805  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
120177897  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
120213283  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
120115371  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
120182767  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
120205539  glutathione S-transferase DHAR1, mitochondrial-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
120140101  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
120161231  glutathione S-transferase DHAR3, chloroplastic-like isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
120164765  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120116257  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
120116565  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120116566  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120116568  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120116599  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120165162  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120165331  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120165357  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120117871  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120129227  L-ascorbate oxidase-like isoform X1 [KO:K00423] [EC:1.10.3.3]
120145239  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
120161844  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
120147759  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120180352  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
120216100  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120200894  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120167162  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120184084  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120184297  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120184635  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
120201450  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120118950  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
120218579  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
120186543  benzaldehyde dehydrogenase, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
120154301  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
120155773  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
120141783  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
120176196  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
120192772  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
120193972  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
120195352  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
120217774  LOW QUALITY PROTEIN: aldehyde dehydrogenase family 7 member B4-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
hsyr00020  Citrate cycle (TCA cycle)
hsyr00040  Pentose and glucuronate interconversions
hsyr00051  Fructose and mannose metabolism
hsyr00520  Amino sugar and nucleotide sugar metabolism
hsyr00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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