KEGG   PATHWAY: kll00260
Entry
kll00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella sp. LTGPAF-6F
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kll00260  Glycine, serine and threonine metabolism
kll00260

Module
kll_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kll00260]
kll_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kll00260]
kll_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kll00260]
kll_M00555  Betaine biosynthesis, choline => betaine [PATH:kll00260]
kll_M00621  Glycine cleavage system [PATH:kll00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella sp. LTGPAF-6F [GN:kll]
Gene
BJF97_01550  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BJF97_04695  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BJF97_00585  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BJF97_13490  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BJF97_26925  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BJF97_04700  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BJF97_04705  threonine synthase [KO:K01733] [EC:4.2.3.1]
BJF97_10135  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BJF97_21620  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BJF97_22435  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BJF97_11390  bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BJF97_27725  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BJF97_23430  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BJF97_24305  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BJF97_25635  glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
BJF97_02490  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BJF97_09165  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BJF97_04655  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BJF97_13550  histidine phosphatase [KO:K15634] [EC:5.4.2.11]
BJF97_27995  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BJF97_27330  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJF97_15200  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJF97_24715  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJF97_08395  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJF97_10325  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BJF97_04620  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BJF97_15670  NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BJF97_28020  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BJF97_28015  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BJF97_13625  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
BJF97_24665  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BJF97_24675  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BJF97_14665  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJF97_05330  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJF97_24670  glycine cleavage system protein H [KO:K02437]
BJF97_29060  creatininase [KO:K08688] [EC:3.5.3.3]
BJF97_21785  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BJF97_08145  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BJF97_08150  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BJF97_25020  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
BJF97_25025  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
BJF97_14795  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BJF97_23490  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BJF97_17810  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BJF97_31560  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BJF97_00770  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BJF97_28625  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BJF97_04345  aldolase [KO:K01753] [EC:4.3.1.18]
BJF97_23995  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BJF97_12660  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BJF97_12665  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BJF97_14535  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BJF97_14530  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kll00010  Glycolysis / Gluconeogenesis
kll00020  Citrate cycle (TCA cycle)
kll00230  Purine metabolism
kll00250  Alanine, aspartate and glutamate metabolism
kll00270  Cysteine and methionine metabolism
kll00290  Valine, leucine and isoleucine biosynthesis
kll00300  Lysine biosynthesis
kll00330  Arginine and proline metabolism
kll00460  Cyanoamino acid metabolism
kll00470  D-Amino acid metabolism
kll00564  Glycerophospholipid metabolism
kll00600  Sphingolipid metabolism
kll00620  Pyruvate metabolism
kll00630  Glyoxylate and dicarboxylate metabolism
kll00640  Propanoate metabolism
kll00680  Methane metabolism
kll00860  Porphyrin metabolism
kll00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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