Entry
Name
Amino sugar and nucleotide sugar metabolism - Klebsiella pneumoniae Kp52.145
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
kpnk00520 Amino sugar and nucleotide sugar metabolism
Ortholog table
Module
kpnk_M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:kpnk00520 ]
kpnk_M00909 UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:kpnk00520 ]
Other DBs
Organism
Klebsiella pneumoniae Kp52.145 [GN:
kpnk ]
Gene
BN49_2333 unnamed protein product; weakly similar to chitinase A1 from Bacillus circulans (sp [KO:K01183 ] [EC:3.2.1.14 ]
BN49_2191 nagZ; highly similar to beta-hexosaminidase from Klebsiella pneumoniae strain 342 (sp [KO:K01207 ] [EC:3.2.1.52 ]
BN49_3974 crr; highly similar to glucose-specific phosphotransferase enzyme IIA component from Salmonella typhimurium (sp [KO:K02777 ] [EC:2.7.1.-]
BN49_1754 nagE; highly similar to PTS system N-acetylglucosamine-specific EIICBA component from Klebsiella pneumoniae (sp [KO:K02804 ] [EC:2.7.1.193 ]
BN49_2203 nagK; highly similar to N-acetyl-D-glucosamine kinase from Citrobacter koseri (sp [KO:K00884 ] [EC:2.7.1.59 ]
BN49_1752 nagA; ighly similar to N-acetylglucosamine-6-phosphate deacetylase from Escherichia coli strain K12 (sp [KO:K01443 ] [EC:3.5.1.25 ]
BN49_1753 nagB; highly similar to glucosamine-6-phosphate deaminase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K02564 ] [EC:3.5.99.6 ]
BN49_1051 unnamed protein product; similar to putative sugar kinase-transcriptional regulator, ATPase domain from Escherichia coli O45:K1 strain S88 - ExPEC (tr [KO:K00847 ] [EC:2.7.1.4 ]
BN49_1311 yajF; highly similar to putative NAGC-like transcriptional regulator from Escherichia coli O157:H7 (tr [KO:K00847 ] [EC:2.7.1.4 ]
BN49_5073 glmS; highly similar to glucosamine--fructose-6-phosphate aminotransferase from Escherichia coli O6 (sp [KO:K00820 ] [EC:2.6.1.16 ]
BN49_0533 glmM; highly similar to phosphoglucosamine mutase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K03431 ] [EC:5.4.2.10 ]
BN49_5072 glmU; highly similar to UDP-N-acetylglucosamine pyrophosphorylase from from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K04042 ] [EC:2.7.7.23 2.3.1.157 ]
BN49_0064 unnamed protein product; highly similar to PTS system N-acetylmuramic acid-specific EIIBC component from Photorhabdus luminescens subsp. laumondii (sp [KO:K11192 ] [EC:2.7.1.192 ]
BN49_2662 murQ; weakly similar to N-acetylmuramic acid 6-phosphate etherase from Enterobacter aerogenes (sp [KO:K07106 ] [EC:4.2.1.126 ]
BN49_0065 unnamed protein product; highly similar to N-acetylmuramic acid 6-phosphate etherase from Enterobacter aerogenes (sp [KO:K07106 ] [EC:4.2.1.126 ]
BN49_3074 anmK; highly similar to anhydro-N-acetylmuramic acid kinase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K09001 ] [EC:2.7.1.170 ]
BN49_0521 murA; highly similar to UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00790 ] [EC:2.5.1.7 ]
BN49_4486 murB; highly similar to UDP-N-acetylenolpyruvoylglucosamine reductase from Shigella sonnei strain Ss046 (sp [KO:K00075 ] [EC:1.3.1.98 ]
BN49_0494 nanE; highly similar to putative N-acetylmannosamine-6-phosphate 2-epimerase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01788 ] [EC:5.1.3.9 ]
BN49_4573 wecB; highly similar to UDP-N-acetylglucosamine 2-epimerase from Escherichia coli strain K12 (sp [KO:K01791 ] [EC:5.1.3.14 ]
BN49_4572 wecC; highly similar to UDP-N-acetyl-D-mannosamine dehydrogenase from Shigella flexneri (sp [KO:K02472 ] [EC:1.1.1.336 ]
BN49_0272 arnA; highly similar to bifunctional polymyxin resistance protein ArnA from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K10011 ] [EC:2.1.2.13 1.1.1.305 ]
BN49_0270 arnB; highly similar to UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K07806 ] [EC:2.6.1.87 ]
BN49_0271 arnC; highly similar to undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K10012 ] [EC:2.4.2.53 ]
BN49_0273 arnD; highly similar to probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K13014 ] [EC:3.5.1.-]
BN49_4726 xynB; highly similar to putative beta-1,4-xylosidase from Klebsiella oxytoca (tr [KO:K01198 ] [EC:3.2.1.37 ]
BN49_2186 unnamed protein product; highly similar to PTS system glucose-specific EIICB component from Salmonella typhimurium (sp [KO:K02779 ] [EC:2.7.1.199 ]
BN49_3954 glk; highly similar to glucokinase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00845 ] [EC:2.7.1.2 ]
BN49_1765 pgm; highly similar to phosphoglucomutase from Escherichia coli strain K12 (sp [KO:K01835 ] [EC:5.4.2.2 ]
BN49_3311 galU; highly similar to glucose-1-phosphate uridylyltransferase from Escherichia coli strain UTI89 - UPEC (tr [KO:K00963 ] [EC:2.7.7.9 ]
BN49_3731 galF; highly similar to UTP--glucose-1-phosphate uridylyltransferase from Klebsiella pneumoniae (sp [KO:K00963 ] [EC:2.7.7.9 ]
BN49_1810 galT; highly similar to galactose-1-phosphate uridylyltransferase from Escherichia coli strain K12 (sp [KO:K00965 ] [EC:2.7.7.12 ]
BN49_1811 galE; highly similar to UDP-glucose 4-epimerase from Salmonella typhimurium (sp [KO:K01784 ] [EC:5.1.3.2 ]
BN49_3707 rfbD; highly similar to probable UDP-galactopyranose mutase from Klebsiella pneumoniae (sp [KO:K01854 ] [EC:5.4.99.9 ]
BN49_3711 unnamed protein product; highly similar to uncharacterized 37.6 kDa protein in cld 5'region from Escherichia coli O111:H-(sp [KO:K08679 ] [EC:5.1.3.6 ]
BN49_1603 unnamed protein product; highly similar to putative PTS system mannose-specific enzyme IIAB from Salmonella typhimurium (tr [KO:K02793 ] [EC:2.7.1.191 ]
BN49_3438 unnamed protein product; highly similar to putative PTS system, mannose-specific component IIAB from Escherichia coli O55:H7 strain CB9615 - EPEC (tr [KO:K02794 ] [EC:2.7.1.191 ]
BN49_3439 unnamed protein product; highly similar to PTS enzyme IIC, mannose-specific from Escherichia coli strain UTI89 - UPEC (tr [KO:K02795 ]
BN49_3440 unnamed protein product; highly similar to mannose-specific enzyme IID component of PTS from Escherichia coli O8 strain IAI1 (tr [KO:K02796 ]
BN49_5019 pgi; highly similar to glucose-6-phosphate isomerase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01810 ] [EC:5.3.1.9 ]
BN49_2577 manA; highly similar to mannose-6-phosphate isomerase from Escherichia coli strain SMS-3-5 - SECEC (tr [KO:K01809 ] [EC:5.3.1.8 ]
BN49_3714 manC; highly similar to mannose-1-phosphate guanylyltransferase from Klebsiella pneumoniae (sp [KO:K00971 ] [EC:2.7.7.13 ]
BN49_0320 glgC; highly similar to glucose-1-phosphate adenylyltransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00975 ] [EC:2.7.7.27 ]
Compound
C00043 UDP-N-acetyl-alpha-D-glucosamine
C00128 CMP-N-acetylneuraminate
C00203 UDP-N-acetyl-D-galactosamine
C00352 D-Glucosamine 6-phosphate
C00357 N-Acetyl-D-glucosamine 6-phosphate
C00446 alpha-D-Galactose 1-phosphate
C00668 alpha-D-Glucose 6-phosphate
C01132 N-Acetyl-D-galactosamine
C01170 UDP-N-acetyl-D-mannosamine
C01219 CDP-4-dehydro-6-deoxy-D-glucose
C01222 GDP-4-dehydro-6-deoxy-D-mannose
C03410 N-Glycoloyl-neuraminate
C03598 CDP-3,6-dideoxy-D-glucose
C03599 CDP-3,6-dideoxy-D-mannose
C03691 CMP-N-glycoloylneuraminate
C03733 UDP-alpha-D-galactofuranose
C03906 beta-L-Arabinose 1-phosphate
C04037 1-Phospho-alpha-D-galacturonate
C04089 UDP-4-dehydro-6-deoxy-D-glucose
C04257 N-Acetyl-D-mannosamine 6-phosphate
C04297 CDP-4-dehydro-3,6-dideoxy-D-glucose
C04501 N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613 UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630 UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C04631 UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385 D-Glucuronate 1-phosphate
C06156 alpha-D-Glucosamine 1-phosphate
C06240 UDP-N-acetyl-D-mannosaminouronate
C06241 N-Acetylneuraminate 9-phosphate
C06377 D-Galactosamine 6-phosphate
C13952 UDP-N-acetyl-D-galactosaminuronic acid
C16156 Undecaprenyl phosphate alpha-L-Ara4FN
C16157 Undecaprenyl phosphate alpha-L-Ara4N
C16183 alpha-D-Arabinopyranose 1-phosphate
C16698 N-Acetylmuramic acid 6-phosphate
C17326 CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C18060 N-Acetyl-alpha-D-galactosamine 1-phosphate
C19725 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745 UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19769 1,6-Anhydro-N-acetyl-beta-muramate
C19823 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19961 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971 UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972 2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20357 UDP-N,N'-diacetylbacillosamine
C20359 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395 UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20418 N,N'-Diacetyllegionaminate
C20419 CMP-N,N'-diacetyllegionaminate
C20424 2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose
C20638 GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672 GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20934 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C21027 N-Acetylmuramic acid alpha-1-phosphate
C21383 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate
C21384 CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C22029 alpha-D-Galactosamine 1-phosphate
Reference
Authors
Wyk P, Reeves P
Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
Journal
Reference
Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
Journal
Reference
Authors
Kessler AC, Haase A, Reeves PR
Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
Journal
Reference
Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
Journal
Reference
Authors
Skurnik M, Peippo A, Ervela E
Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
Journal
Reference
Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Journal
Reference
Authors
Ringenberg M, Lichtensteiger C, Vimr E
Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
Journal
Reference
Authors
McCoy AJ, Sandlin RC, Maurelli AT
Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
Journal
Reference
Authors
JACOBSON B, DAVIDSON EA
Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
Journal
J Biol Chem 237:638-42 (1962)
Reference
Authors
Seifert GJ
Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
Journal
Reference
Authors
Uehara T, Park JT
Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
Journal
Reference
Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
Journal
Reference
Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
Journal
Reference
Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
Journal
Reference
Authors
Campbell CT, Yarema KJ
Title
Large-scale approaches for glycobiology.
Journal
Reference
Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
Journal
Reference
Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
Journal
Reference
Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
Journal
Reference
Authors
Oka T, Nemoto T, Jigami Y
Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
Journal
Reference
Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
Journal
Reference
Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
Journal
Reference
Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
Journal
Reference
Authors
Albermann C, Piepersberg W
Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
Journal
Related pathway
kpnk00040 Pentose and glucuronate interconversions
kpnk00525 Acarbose and validamycin biosynthesis
KO pathway
LinkDB
All DBs