KEGG   PATHWAY: lcf00983
Entry
lcf00983                    Pathway                                
Name
Drug metabolism - other enzymes - Lates calcarifer (barramundi perch)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
lcf00983  Drug metabolism - other enzymes
lcf00983

Organism
Lates calcarifer (barramundi perch) [GN:lcf]
Gene
108878576  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
108875261  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
108875159  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X2 [KO:K00088] [EC:1.1.1.205]
108882556  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
108889258  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
108873784  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
108889567  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
108877173  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108879084  LOW QUALITY PROTEIN: inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
108883895  UDP-glucuronosyltransferase 1A1 [KO:K00699] [EC:2.4.1.17]
108876936  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108876938  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
108876940  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108886882  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108876852  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
108893988  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
108886986  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
108874615  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
108876738  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
108876939  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
108876941  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
108877155  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
108879425  LOW QUALITY PROTEIN: UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
108881641  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
108881642  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
108892052  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
108892294  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108900696  UDP-glucuronosyltransferase 2B13-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108893406  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
108897862  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
108884063  cdab; cytidine deaminase b isoform X1 [KO:K01489] [EC:3.5.4.5]
108898223  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
108902388  zgc:103586 isoform X2 [KO:K01489] [EC:3.5.4.5]
108901402  thymidine phosphorylase isoform X1 [KO:K00758] [EC:2.4.2.4]
108884496  dpydb; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
108887243  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
108878574  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
108901065  uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
108891972  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
108873983  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
108883811  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
108878924  uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
108889518  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
108890449  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
108882191  LOW QUALITY PROTEIN: uridine-cytidine kinase-like 1a [KO:K00876] [EC:2.7.1.48]
108894844  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
108875678  thymidine kinase, cytosolic isoform X2 [KO:K00857] [EC:2.7.1.21]
108902828  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
108883744  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
108900846  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
108894047  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
108888319  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
108898139  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
108882220  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
108891564  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
108890024  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
108876810  nucleoside diphosphate kinase A2 [KO:K00940] [EC:2.7.4.6]
108882397  nucleoside diphosphate kinase A 2 [KO:K00940] [EC:2.7.4.6]
108895557  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
108878852  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
108897010  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
108881003  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
108881025  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
108887906  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
108877018  arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
108876876  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like isoform X1 [KO:K00622] [EC:2.3.1.5]
108875506  LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
108883829  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
108894591  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
108897969  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
108891126  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
108876447  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
108881636  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
108893003  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
108893008  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
108893009  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
108900399  LOW QUALITY PROTEIN: glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
108900400  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
108900401  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
108897288  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
108897551  microsomal glutathione S-transferase 1 isoform X13 [KO:K00799] [EC:2.5.1.18]
108897552  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system