KEGG   PATHWAY: lpic00983
Entry
lpic00983                   Pathway                                
Name
Drug metabolism - other enzymes - Lytechinus pictus (painted urchin)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
lpic00983  Drug metabolism - other enzymes
lpic00983

Organism
Lytechinus pictus (painted urchin) [GN:lpic]
Gene
129274905  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
129274906  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
129255570  inosine-5'-monophosphate dehydrogenase 1b-like [KO:K00088] [EC:1.1.1.205]
129276751  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
129276270  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
129253580  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
129253619  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
129254852  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
129279796  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
129256423  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
129257533  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
129282506  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
129264472  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129264825  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129254440  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129254936  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129254937  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129281843  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129278019  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
129257327  carboxylesterase 5A-like [KO:K01044] [EC:3.1.1.1]
129255792  uncharacterized protein LOC129255792 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
129262590  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129274753  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
129274756  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129277213  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
129277489  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
129253996  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129254307  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
129254308  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
129254309  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129265013  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
129278303  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
129265879  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
129266163  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129278792  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
129254968  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
129266423  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129266446  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129266721  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
129266726  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129267360  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129267754  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
129256125  UDP-glucuronosyltransferase 2B23-like [KO:K00699] [EC:2.4.1.17]
129256477  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
129256649  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129268290  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129280367  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
129257127  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
129268792  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129268795  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129270754  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
129282516  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129282550  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129282966  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129282969  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129258812  UDP-glucuronosyltransferase 2B23-like [KO:K00699] [EC:2.4.1.17]
129259001  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
129259004  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
129270893  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129271239  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129259319  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
129271694  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129271696  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
129271937  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
129271940  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
129272151  UDP-glucuronosyltransferase 1-2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129272161  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
129260551  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
129260552  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129260609  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
129260624  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
129272870  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
129260882  UDP-glucuronosyltransferase 2B33-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129260864  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
129260954  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129273308  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129274344  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
129274575  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129274650  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129257154  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
129276170  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
129282480  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
129282650  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
129270931  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
129263304  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
129254828  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
129257553  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
129278023  LOW QUALITY PROTEIN: uridine-cytidine kinase 2-like [KO:K00876] [EC:2.7.1.48]
129278044  uridine-cytidine kinase 2-like [KO:K00876] [EC:2.7.1.48]
129280483  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
129280778  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
129254181  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
129269459  thymidine kinase, cytosolic-like isoform X1 [KO:K00857] [EC:2.7.1.21]
129268287  LOW QUALITY PROTEIN: uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
129270864  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
129260829  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
129280714  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
129270812  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
129270813  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
129278877  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
129279150  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
129268597  nucleoside diphosphate kinase A 2-like [KO:K00940] [EC:2.7.4.6]
129280528  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
129261022  nucleoside diphosphate kinase A2-like [KO:K00940] [EC:2.7.4.6]
129256782  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
129256783  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
129274675  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129274719  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129274731  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129276271  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129253721  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
129277194  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
129277470  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
129277660  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
129278360  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
129278361  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
129254489  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
129254687  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129265888  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
129266810  glutathione S-transferase alpha-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129256146  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
129281355  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129281743  S-crystallin SL11-like [KO:K00799] [EC:2.5.1.18]
129258295  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
129258435  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
129258527  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
129258575  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
129259111  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
129259112  glutathione S-transferase alpha-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129270912  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
129284222  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129259188  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
129259322  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
129272678  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129272689  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129272700  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129272850  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129261120  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
129273534  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
129271529  glutathione S-transferase Mu 1-like [KO:K23790] [EC:2.5.1.18]
129260511  S-crystallin SL11-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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