KEGG   PATHWAY: lroh00983
Entry
lroh00983                   Pathway                                
Name
Drug metabolism - other enzymes - Labeo rohita (rohu)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
lroh00983  Drug metabolism - other enzymes
lroh00983

Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127176196  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
127156219  hprt1l; hypoxanthine phosphoribosyltransferase 1, like [KO:K00760] [EC:2.4.2.8]
127163810  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
127169901  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
127181113  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
127180945  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
127181904  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127179899  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127151858  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
127160965  uncharacterized protein LOC127160965 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
127170631  UDP-glucuronosyltransferase 1A5 [KO:K00699] [EC:2.4.1.17]
127165527  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
127171581  ugt5d1; LOW QUALITY PROTEIN: UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
127155917  UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
127165961  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127165963  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127165964  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127165969  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127166211  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127172535  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 [KO:K00699] [EC:2.4.1.17]
127156697  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127156698  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
127156699  ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
127156700  ugt5a5; UDP glucuronosyltransferase 5 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
127156701  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
127173132  UDP-glucuronosyltransferase 1-6 isoform X1 [KO:K00699] [EC:2.4.1.17]
127167530  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
127167760  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
127180479  ugt5f1; UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
127169396  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
127165488  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
127154814  cdaa; cytidine deaminase a [KO:K01489] [EC:3.5.4.5]
127172945  cdab; cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
127167637  zgc:103586 isoform X1 [KO:K01489] [EC:3.5.4.5]
127164424  tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
127156007  dpyda.1; dihydropyrimidine dehydrogenase a, tandem duplicate 1 [KO:K00207] [EC:1.3.1.2]
127175303  dpydb; LOW QUALITY PROTEIN: dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
127178835  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
127169646  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
127170772  upp2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
127179044  upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
127169723  uck2a; uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
127154585  uckl1b; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127180379  uck2b; uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
127169250  uckl1a; uridine-cytidine kinase-like 1a [KO:K00876] [EC:2.7.1.48]
127153021  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
127183165  si:ch211-243j20.2; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127173053  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
127167899  tk2; thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
127155054  cmpk; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
127152879  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
127182238  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
127151804  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
127163596  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
127182488  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
127166687  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
127161516  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
127174551  nme2a; NME/NM23 nucleoside diphosphate kinase 2a isoform X1 [KO:K00940] [EC:2.7.4.6]
127162660  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
127180497  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
127167916  arylamine N-acetyltransferase, pineal gland isozyme NAT-3-like [KO:K00622] [EC:2.3.1.5]
127180534  zgc:101040; arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
127181939  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127181940  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
127182520  mgst3a; microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
127164416  mgst1.1; microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
127164417  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127164740  gstt2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
127176661  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
127152143  gstt1b; glutathione S-transferase theta-1b [KO:K00799] [EC:2.5.1.18]
127174802  gsta.1; glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
127169117  gstt1a; glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
127175058  mgst3b; microsomal glutathione S-transferase 3b [KO:K00799] [EC:2.5.1.18]
127175195  gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
127175197  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127169672  glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
127169673  glutathione S-transferase Mu 4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127175787  gstp1.2; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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