KEGG   PATHWAY: lsm04150
Entry
lsm04150                    Pathway                                
Name
mTOR signaling pathway - Lepeophtheirus salmonis (salmon louse)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
lsm04150  mTOR signaling pathway
lsm04150

Organism
Lepeophtheirus salmonis (salmon louse) [GN:lsm]
Gene
121121570  Y+L amino acid transporter 2-like [KO:K13780]
121122074  large neutral amino acids transporter small subunit 1-like isoform X1 [KO:K13780]
121114344  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
121132321  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121118018  V-type proton ATPase subunit B [KO:K02147]
121119412  V-type proton ATPase subunit C-like [KO:K02148]
121131603  V-type proton ATPase subunit D-like [KO:K02149]
121117384  V-type proton ATPase subunit E-like [KO:K02150]
121119834  V-type proton ATPase subunit F-like [KO:K02151]
121117153  V-type proton ATPase subunit G 1-like [KO:K02152]
121117703  V-type proton ATPase subunit H-like isoform X1 [KO:K02144]
121120859  ragulator complex protein LAMTOR2-like isoform X1 [KO:K20398]
121122580  ragulator complex protein LAMTOR3-like [KO:K04370]
121128446  uncharacterized protein LOC121128446 isoform X1 [KO:K09594]
121117696  folliculin-interacting protein 1-like isoform X1 [KO:K20401]
121119105  ras-related GTP-binding protein A-like [KO:K16185]
121123986  ras-related GTP-binding protein C-like [KO:K16186]
121124244  sestrin homolog [KO:K20394]
121120530  GATOR complex protein MIOS-like [KO:K20407]
121127618  nucleoporin SEH1-like [KO:K14299]
121129624  GATOR complex protein WDR24-like [KO:K20408]
121115272  GATOR complex protein WDR59-like [KO:K20409]
121130023  GATOR complex protein WDR59-like [KO:K20409]
121127044  protein SEC13 homolog [KO:K14004]
121129170  GATOR complex protein Iml1-like [KO:K20404]
121114142  GATOR complex protein NPRL2-like [KO:K20405]
121130035  GATOR complex protein NPRL3-like [KO:K20406]
121129895  S-phase kinase-associated protein 2-like [KO:K03875]
121117218  regulatory-associated protein of mTOR-like [KO:K07204]
121127434  LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
121122400  target of rapamycin complex subunit lst8-like [KO:K08266]
121130073  uncharacterized protein LOC121130073 [KO:K20403]
121123869  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
121114837  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
121116385  serine/threonine-protein kinase unc-51-like isoform X1 [KO:K08269] [EC:2.7.11.1]
121124566  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
121115910  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
121117524  eukaryotic translation initiation factor 4E-like [KO:K03259]
121128316  eukaryotic translation initiation factor 4E-like [KO:K03259]
121113704  serine/threonine-protein kinase Aurora-2-like [KO:K04688] [EC:2.7.11.1]
121123887  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
121129366  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
121121163  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
121123260  40S ribosomal protein S6-like [KO:K02991]
121120471  STE20-related kinase adapter protein alpha-like [KO:K08271]
121121072  serine/threonine-protein kinase STK11-like isoform X1 [KO:K07298] [EC:2.7.11.1]
121116935  protein Mo25-like [KO:K08272]
121128263  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
121122415  LOW QUALITY PROTEIN: hamartin-like [KO:K07206]
121125455  tuberin-like [KO:K07207]
121120376  TBC1 domain family member 7-like isoform X1 [KO:K20396]
121117200  GTP-binding protein Rheb-like [KO:K07208]
121126884  protein Wnt-4-like isoform X1 [KO:K00408]
121116068  protein Wnt-5b-like [KO:K00444]
121116299  protein Wnt-8-like [KO:K00714]
121130065  frizzled-1-like [KO:K02432]
121127370  frizzled-4-like isoform X1 [KO:K02354]
121117382  frizzled-5-like [KO:K02375]
121114310  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
121130116  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
121123548  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
121121449  mitogen-activated protein kinase HOG1-like [KO:K03083] [EC:2.7.11.26]
121115991  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
121127326  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
121123859  protein son of sevenless-like isoform X1 [KO:K03099]
121122432  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K07827]
121122508  ras-like protein isoform X1 [KO:K07827]
121114024  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
121115813  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121122870  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
121127522  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121122810  ribosomal protein S6 kinase 2 beta-like [KO:K04373] [EC:2.7.11.1]
121114447  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121125791  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121123901  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121127823  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
121117650  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
121126301  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta-like [KO:K04467] [EC:2.7.11.10]
121123073  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
121117299  rapamycin-insensitive companion of mTOR-like [KO:K08267]
121116351  ras-like GTP-binding protein Rho1 [KO:K04513]
121117787  GTP-binding protein rho5-like [KO:K04513]
121119323  calcium-dependent protein kinase C-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
lsm00561  Glycerolipid metabolism
lsm04140  Autophagy - animal
KO pathway
ko04150   
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