KEGG   PATHWAY: maj00260
Entry
maj00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Metarhizium robertsii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
maj00260  Glycine, serine and threonine metabolism
maj00260

Module
maj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:maj00260]
maj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:maj00260]
maj_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:maj00260]
maj_M00621  Glycine cleavage system [PATH:maj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Metarhizium robertsii [GN:maj]
Gene
MAA_06807  aspartokinase [KO:K00928] [EC:2.7.2.4]
MAA_07395  hypothetical protein [KO:K00133] [EC:1.2.1.11]
MAA_02046  hypothetical protein [KO:K00003] [EC:1.1.1.3]
MAA_03125  hypothetical protein [KO:K00872] [EC:2.7.1.39]
MAA_02603  threonine synthase [KO:K01733] [EC:4.2.3.1]
MAA_11412  candidapepsin-4 precursor [KO:K01620] [EC:4.1.2.48]
MAA_03355  threonine aldolase-like protein [KO:K01620] [EC:4.1.2.48]
MAA_02807  Pyridoxal phosphate-dependent transferase, major domain protein [KO:K01620] [EC:4.1.2.48]
MAA_04595  cytosolic Glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MAA_08242  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MAA_02574  alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
MAA_08472  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
MAA_04672  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
MAA_05119  Signal recognition particle, SRP54 subunit, GTPase [KO:K15918] [EC:2.7.1.31]
MAA_02129  d-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MAA_06843  D-3-phosphoglycerate dehydrogenase 1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MAA_01249  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MAA_09060  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
MAA_02715  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
MAA_05937  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
MAA_08578  Amine oxidase [KO:K00274] [EC:1.4.3.4]
MAA_03753  Amine oxidase [KO:K00274] [EC:1.4.3.4]
MAA_10281  Amine oxidase [KO:K00274] [EC:1.4.3.4]
MAA_09819  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MAA_05085  membrane copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MAA_08459  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MAA_06939  copper methylamine oxidase precursor [KO:K00276] [EC:1.4.3.21]
MAA_06882  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MAA_11450  Major facilitator superfamily domain protein [KO:K00276] [EC:1.4.3.21]
MAA_08431  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MAA_04008  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MAA_04490  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MAA_01320  2-oxo acid dehydrogenase, lipoyl-binding site [KO:K02437]
MAA_07041  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
MAA_10016  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
MAA_02320  hypothetical protein [KO:K00273] [EC:1.4.3.3]
MAA_09776  lysine amidinotransferase [KO:K00613] [EC:2.1.4.1]
MAA_04513  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
MAA_01887  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MAA_00906  aminomethyl transferase [KO:K00309] [EC:1.5.3.10]
MAA_07806  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_02227  fructosyl-amino acid oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_02260  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_07783  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_09919  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_11614  phosphotransferase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_10229  amine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
MAA_09697  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MAA_03905  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
MAA_05189  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MAA_02997  IlvA, threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MAA_00132  Serine/threonine dehydratase, pyridoxal-phosphate-binding site [KO:K17989] [EC:4.3.1.17 4.3.1.19]
MAA_08733  Serine/threonine dehydratase, pyridoxal-phosphate-binding site [KO:K17989] [EC:4.3.1.17 4.3.1.19]
MAA_02327  alanine racemase domain protein [KO:K20498] [EC:4.3.1.18]
MAA_02672  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
maj00010  Glycolysis / Gluconeogenesis
maj00020  Citrate cycle (TCA cycle)
maj00230  Purine metabolism
maj00250  Alanine, aspartate and glutamate metabolism
maj00270  Cysteine and methionine metabolism
maj00290  Valine, leucine and isoleucine biosynthesis
maj00300  Lysine biosynthesis
maj00330  Arginine and proline metabolism
maj00460  Cyanoamino acid metabolism
maj00470  D-Amino acid metabolism
maj00564  Glycerophospholipid metabolism
maj00600  Sphingolipid metabolism
maj00620  Pyruvate metabolism
maj00630  Glyoxylate and dicarboxylate metabolism
maj00640  Propanoate metabolism
maj00680  Methane metabolism
maj00860  Porphyrin metabolism
maj00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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