KEGG   PATHWAY: malb03013
Entry
malb03013                   Pathway                                
Name
Nucleocytoplasmic transport - Monopterus albus (swamp eel)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
malb03013  Nucleocytoplasmic transport
malb03013

Other DBs
GO: 0050658
Organism
Monopterus albus (swamp eel) [GN:malb]
Gene
109966032  aaas; aladin isoform X1 [KO:K14320]
109968127  nupl2; nucleoporin-like protein 2 isoform X1 [KO:K14321]
109957325  gle1; LOW QUALITY PROTEIN: nucleoporin GLE1 [KO:K18723]
109956102  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
109951216  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
109956054  rae1; mRNA export factor isoform X1 [KO:K14298]
109974209  nup98; LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96 [KO:K14297]
109960617  nup214; LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
109968496  nup88; nuclear pore complex protein Nup88 [KO:K14318]
109968299  RANBP2-like and GRIP domain-containing protein 8 [KO:K12172] [EC:2.3.2.-]
109952669  rangap1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
109952688  LOW QUALITY PROTEIN: ran GTPase-activating protein 1-like [KO:K14319]
109963560  ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
109972417  SUMO-conjugating enzyme UBC9-like [KO:K10577]
109957172  small ubiquitin-related modifier 3 [KO:K12160]
109966247  small ubiquitin-related modifier 2-like isoform X1 [KO:K12160]
109968062  small ubiquitin-related modifier 3 [KO:K12160]
109969540  sumo2; small ubiquitin-related modifier 2 [KO:K12160]
109955667  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
109969129  nup160; nuclear pore complex protein Nup160 [KO:K14303]
109969446  nup85; nuclear pore complex protein Nup85 [KO:K14304]
109952626  sec13; protein SEC13 homolog [KO:K14004]
109967610  nup107; nuclear pore complex protein Nup107 [KO:K14301]
109974818  nup133; LOW QUALITY PROTEIN: nuclear pore complex protein Nup133 [KO:K14300]
109963867  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
109962357  nup43; nucleoporin Nup43 [KO:K14305]
109967818  nup37; nucleoporin Nup37 [KO:K14302]
109954488  ahctf1; protein ELYS [KO:K25129]
109958056  nup62; nuclear pore glycoprotein p62 [KO:K14306]
109963708  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
109972364  nup54; nucleoporin p54 [KO:K14308]
109961818  nup205; nuclear pore complex protein Nup205 [KO:K14310]
109972300  nup188; LOW QUALITY PROTEIN: nucleoporin NUP188 homolog [KO:K14311]
109970810  nup155; nuclear pore complex protein Nup155 [KO:K14312]
109962542  nup93; nuclear pore complex protein Nup93 [KO:K14309]
109973929  nup35; nucleoporin NUP53 isoform X1 [KO:K14313]
109955482  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
109966057  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
109959191  nuclear envelope pore membrane protein POM 121-like isoform X1 [KO:K14316]
109958109  tmem33; transmembrane protein 33 [KO:K20724]
109961702  tpr; nucleoprotein TPR isoform X1 [KO:K09291]
109974728  nucleoprotein TPR-like [KO:K09291]
109967665  nup50; nuclear pore complex protein Nup50 [KO:K14295]
109963907  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
109968067  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
109961481  importin subunit alpha-5-like [KO:K23940]
109972008  kpna2; importin subunit alpha-1 [KO:K15043]
109973500  importin subunit alpha-1-like [KO:K15043]
109970704  importin subunit alpha-5-like [KO:K15043]
109965395  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
109968999  kpna4; importin subunit alpha-3 [KO:K23583]
109970529  kpna6; importin subunit alpha-7 [KO:K15042]
109973471  kpnb1; importin subunit beta-1 [KO:K14293]
109967779  transportin-1 [KO:K18752]
109957855  transportin-2 [KO:K18727]
109969466  transportin-2-like [KO:K18727]
109967729  tnpo3; transportin-3 isoform X1 [KO:K15436]
109968797  ipo4; importin-4 [KO:K20221]
109960569  ipo5; importin-5 [KO:K20222]
109965572  ipo7; importin-7 [KO:K20223]
109973970  ipo8; importin-8 isoform X1 [KO:K18755]
109964429  ipo9; importin-9 [KO:K20224]
109956533  ipo11; importin-11 isoform X1 [KO:K25201]
109974869  ipo13; importin-13 [KO:K25202]
109970637  importin-13-like [KO:K25202]
109973334  snupn; snurportin-1 isoform X1 [KO:K13151]
109974811  exportin-1-like [KO:K14290]
109973586  exportin-1 [KO:K14290]
109964527  cse1l; exportin-2 [KO:K18423]
109967715  xpot; exportin-T [KO:K14288]
109970947  xpo4; exportin-4 [KO:K25203]
109961891  xpo5; exportin-5 [KO:K14289]
109958879  xpo6; exportin-6 [KO:K25204]
109951183  xpo7; exportin-7 [KO:K18460]
109953755  ran; GTP-binding nuclear protein Ran [KO:K07936]
109956834  elongation factor 1-alpha 1-like [KO:K03231]
109961115  elongation factor 1-alpha 1 [KO:K03231]
109953430  elongation factor 1-alpha isoform X1 [KO:K03231]
109953431  elongation factor 1-alpha-like [KO:K03231]
109975010  elongation factor 1-alpha 1-like [KO:K03231]
109971503  elongation factor 1-alpha-like [KO:K03231]
109960918  phax; phosphorylated adapter RNA export protein [KO:K14291]
109956697  ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
109961773  nuclear cap-binding protein subunit 2-like [KO:K12883]
109968987  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
109965564  rbm8a; RNA-binding protein 8A [KO:K12876]
109965695  magoh; protein mago nashi homolog [KO:K12877]
109967533  casc3; protein CASC3 [KO:K14323]
109953486  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109962613  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109974410  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109955743  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
109951543  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
109973213  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
109972792  pnn; pinin [KO:K13114]
109956830  THO complex subunit 4-like [KO:K12881]
109958939  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
109966845  upf1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
109969255  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
109967603  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
109955813  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
109965338  regulator of nonsense transcripts 3A-like [KO:K14328]
109955377  nxf1; nuclear RNA export factor 1 [KO:K14284]
109955175  NTF2-related export protein 2-like [KO:K14285]
109955254  NTF2-related export protein 2-like [KO:K14285]
109964986  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
109970282  pym1; partner of Y14 and mago [KO:K14294]
109955440  thoc1; THO complex subunit 1 isoform X1 [KO:K12878]
109959435  thoc2; THO complex subunit 2 [KO:K12879]
109956904  thoc5; THO complex subunit 5 homolog [KO:K13174]
109967553  thoc6; THO complex subunit 6 homolog [KO:K13175]
109956096  thoc7; THO complex subunit 7 homolog [KO:K13176]
109953909  THO complex subunit 7 homolog [KO:K13176]
109956685  thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
malb03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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