KEGG   PATHWAY: masi00983
Entry
masi00983                   Pathway                                
Name
Drug metabolism - other enzymes - Myxocyprinus asiaticus (Chinese sucker)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
masi00983  Drug metabolism - other enzymes
masi00983

Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127418275  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
127412900  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
127437473  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
127436314  hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
127436699  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
127424696  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
127456298  inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
127414496  inosine-5'-monophosphate dehydrogenase 2-like isoform X1 [KO:K00088] [EC:1.1.1.205]
127434839  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
127416892  inosine-5'-monophosphate dehydrogenase 1a-like isoform X1 [KO:K00088] [EC:1.1.1.205]
127456360  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
127416652  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
127424969  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127420637  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
127455270  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127411091  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
127416114  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
127410411  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
127435562  uncharacterized protein LOC127435562 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
127437090  fatty acyl-CoA hydrolase precursor, medium chain-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
127430279  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127430305  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127444455  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
127444456  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127431565  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127437634  UDP glucuronosyltransferase 5 family, polypeptide A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
127437635  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
127437742  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
127437753  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127437758  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127445266  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127445267  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127426200  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127426220  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
127432551  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127446774  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127433854  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
127446947  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127428079  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
127434431  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
127447795  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
127447875  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
127416602  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127435597  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
127435796  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
127424175  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
127433303  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
127418848  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
127420011  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
127426332  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
127428242  cytidine deaminase b [KO:K01489] [EC:3.5.4.5]
127453807  zgc:103586 [KO:K01489] [EC:3.5.4.5]
127436872  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
127435158  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
127440388  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
127442398  dihydropyrimidine dehydrogenase [NADP(+)]-like isoform X1 [KO:K00207] [EC:1.3.1.2]
127453142  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
127424339  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
127446852  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
127453436  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
127454252  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
127424659  uridine-cytidine kinase 2-A [KO:K00876] [EC:2.7.1.48]
127419237  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127420487  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127414832  uridine-cytidine kinase 2-A-like isoform X1 [KO:K00876] [EC:2.7.1.48]
127441090  uridine-cytidine kinase 2-B [KO:K00876] [EC:2.7.1.48]
127410054  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127429275  uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
127442551  uridine-cytidine kinase 2-B-like isoform X1 [KO:K00876] [EC:2.7.1.48]
127424198  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
127428124  thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
127409975  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
127447874  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
127441673  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
127442493  UMP-CMP kinase-like isoform X1 [KO:K13800] [EC:2.7.4.14]
127431150  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
127428994  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
127425130  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
127420971  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
127410141  ribonucleoside-diphosphate reductase subunit M2-like isoform X1 [KO:K10808] [EC:1.17.4.1]
127416494  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
127425153  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
127450306  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127451383  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127421072  nucleoside diphosphate kinase A2 [KO:K00940] [EC:2.7.4.6]
127446362  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127452016  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
127427288  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127409820  nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
127416219  nucleoside diphosphate kinase 6-like isoform X1 [KO:K00940] [EC:2.7.4.6]
127423391  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
127455801  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
127417213  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
127446442  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
127453914  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
127417039  zgc:101040; arylamine N-acetyltransferase, pineal gland isozyme NAT-10 [KO:K00622] [EC:2.3.1.5]
127412000  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127424482  glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
127430586  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
127430607  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127436555  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127412320  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127412373  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127412374  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
127413061  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
127413568  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127438027  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127413946  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
127414971  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
127421204  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
127415401  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127421514  glutathione S-transferase rho [KO:K00799] [EC:2.5.1.18]
127409751  microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
127428915  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127434995  microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
127434997  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
127417565  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
127424223  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
127418176  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
127413352  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
127413353  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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