KEGG   PATHWAY: maua03018
Entry
maua03018                   Pathway                                
Name
RNA degradation - Mesocricetus auratus (golden hamster)
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
maua03018  RNA degradation
maua03018

Other DBs
GO: 0006401
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101839621  Dcps; m7GpppX diphosphatase [KO:K12584] [EC:3.6.1.59]
101838001  Exosc1; exosome complex component CSL4 isoform X1 [KO:K07573]
101835291  Exosc2; exosome complex component RRP4 [KO:K03679]
101844209  Exosc3; exosome complex component RRP40 [KO:K03681]
101830530  Exosc8; exosome complex component RRP43 isoform X1 [KO:K12586]
101822935  Exosc6; exosome complex component MTR3 [KO:K12587]
101837091  Exosc7; exosome complex component RRP42 [KO:K12589]
101838373  Exosc4; exosome complex component RRP41 [KO:K11600]
101834867  Exosc5; exosome complex component RRP46 [KO:K12590]
101842509  Exosc9; exosome complex component RRP45 isoform X1 [KO:K03678]
101841709  Dis3; exosome complex exonuclease RRP44 isoform X1 [KO:K12585] [EC:3.1.13.-]
101835009  Exosc10; exosome component 10 isoform X1 [KO:K12591] [EC:3.1.13.-]
101837417  C1d; nuclear nucleic acid-binding protein C1D [KO:K12592]
101832280  Mphosph6; M-phase phosphoprotein 6 isoform X1 [KO:K12593]
101830607  Dis3l; DIS3-like exonuclease 1 isoform X1 [KO:K18681] [EC:3.1.13.-]
101836167  Tent4a; terminal nucleotidyltransferase 4A isoform X1 [KO:K03514] [EC:2.7.7.19]
101839589  Tent4b; terminal nucleotidyltransferase 4B isoform X2 [KO:K03514] [EC:2.7.7.19]
101832814  Zcchc7; zinc finger CCHC domain-containing protein 7 [KO:K12597]
101842574  Mtrex; exosome RNA helicase MTR4 [KO:K12598] [EC:5.6.2.6]
101830400  Skiv2l; helicase SKI2W isoform X2 [KO:K12599] [EC:5.6.2.6]
101839354  Ttc37; tetratricopeptide repeat protein 37 isoform X1 [KO:K12600]
101838846  Wdr61; WD repeat-containing protein 61 [KO:K12602]
101833244  Cnot6; CCR4-NOT transcription complex subunit 6 isoform X1 [KO:K12603] [EC:3.1.13.4]
101830139  Cnot6l; CCR4-NOT transcription complex subunit 6-like isoform X1 [KO:K12603] [EC:3.1.13.4]
101843614  Cnot1; CCR4-NOT transcription complex subunit 1 isoform X1 [KO:K12604]
101841916  Cnot2; CCR4-NOT transcription complex subunit 2 isoform X3 [KO:K12605]
101833966  Cnot3; CCR4-NOT transcription complex subunit 3 isoform X4 [KO:K12580]
101841921  Cnot4; CCR4-NOT transcription complex subunit 4 isoform X2 [KO:K10643] [EC:2.3.2.27]
101838186  Cnot7; CCR4-NOT transcription complex subunit 7 isoform X1 [KO:K12581]
101834961  Cnot8; CCR4-NOT transcription complex subunit 8 isoform X1 [KO:K12581]
101844545  Cnot9; CCR4-NOT transcription complex subunit 9 isoform X1 [KO:K12606]
101838666  Cnot10; CCR4-NOT transcription complex subunit 10 isoform X4 [KO:K12607]
101840573  Dhx36; ATP-dependent DNA/RNA helicase DHX36 [KO:K14442] [EC:5.6.2.6]
101838905  Pnldc1; poly(A)-specific ribonuclease PNLDC1 [KO:K01148] [EC:3.1.13.4]
101839677  Parn; poly(A)-specific ribonuclease PARN isoform X1 [KO:K01148] [EC:3.1.13.4]
101844918  Btg2; protein BTG2 [KO:K14443]
101839476  Tob1; protein Tob1 [KO:K14443]
101830421  Btg4; protein BTG4 [KO:K14443]
101839979  Tob2; protein Tob2 [KO:K14443]
101835566  Btg1; protein BTG1 [KO:K14443]
101828091  Btg3; protein BTG3 [KO:K14443]
101822964  protein BTG1-like [KO:K14443]
101837745  Pabpc1l; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
101843657  polyadenylate-binding protein 1-like [KO:K13126]
101826002  Pabpc5; polyadenylate-binding protein 5 [KO:K13126]
101843483  Pabpc1; polyadenylate-binding protein 1 [KO:K13126]
101828632  Pabpc4l; polyadenylate-binding protein 4-like [KO:K13126]
110339632  polyadenylate-binding protein 1-like 2 [KO:K13126]
101839611  Pabpc4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
101844539  polyadenylate-binding protein 1-like [KO:K13126]
121139988  polyadenylate-binding protein 1-like 2 [KO:K13126]
101827077  Pan2; PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1 [KO:K12571] [EC:3.1.13.4]
101840957  Pan3; LOW QUALITY PROTEIN: PAN2-PAN3 deadenylation complex subunit PAN3 [KO:K12572]
101825790  Dcp1a; mRNA-decapping enzyme 1A isoform X1 [KO:K12610] [EC:3.-.-.-]
101835216  Dcp1b; mRNA-decapping enzyme 1B isoform X1 [KO:K12611] [EC:3.-.-.-]
101836696  Dcp2; m7GpppN-mRNA hydrolase [KO:K12613] [EC:3.6.1.62]
101833322  Ddx6; probable ATP-dependent RNA helicase DDX6 [KO:K12614] [EC:5.6.2.7]
101844806  Edc3; enhancer of mRNA-decapping protein 3 [KO:K12615]
121138234  enhancer of mRNA-decapping protein 3-like isoform X1 [KO:K12615]
101832553  Edc4; enhancer of mRNA-decapping protein 4 isoform X7 [KO:K12616]
101823589  Patl1; protein PAT1 homolog 1 isoform X1 [KO:K12617]
101836133  Xrn1; 5'-3' exoribonuclease 1 isoform X1 [KO:K12618] [EC:3.1.13.-]
101837597  Xrn2; 5'-3' exoribonuclease 2 isoform X1 [KO:K12619] [EC:3.1.13.-]
101840553  U8 snoRNA-decapping enzyme isoform X2 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101823712  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101839630  Lsm1; U6 snRNA-associated Sm-like protein LSm1 [KO:K12620]
101828344  Lsm2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
101843944  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121136919  Lsm3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
101830297  Lsm4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
101825942  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
101841689  Lsm5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
101830615  Lsm6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
101838265  Lsm7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
106021866  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
121133000  Lsm8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
101829906  Eno1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
101824431  LOW QUALITY PROTEIN: alpha-enolase-like [KO:K01689] [EC:4.2.1.11]
101844253  Eno2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
101839187  Eno3; beta-enolase isoform X2 [KO:K01689] [EC:4.2.1.11]
101824867  Pnpt1; polyribonucleotide nucleotidyltransferase 1, mitochondrial [KO:K00962] [EC:2.7.7.8]
101832271  Pfkl; ATP-dependent 6-phosphofructokinase, liver type isoform X1 [KO:K00850] [EC:2.7.1.11]
101830760  Pfkm; ATP-dependent 6-phosphofructokinase, muscle type isoform X1 [KO:K00850] [EC:2.7.1.11]
101840180  ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
101837753  Hspa9; stress-70 protein, mitochondrial [KO:K04043]
106021236  60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101844216  Hspd1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
121137093  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
Reference
PMID:19239894
  Authors
Houseley J, Tollervey D
  Title
The many pathways of RNA degradation.
  Journal
Cell 136:763-76 (2009)
DOI:10.1016/j.cell.2009.01.019
Reference
PMID:16968219
  Authors
Buttner K, Wenig K, Hopfner KP
  Title
The exosome: a macromolecular cage for controlled RNA degradation.
  Journal
Mol Microbiol 61:1372-9 (2006)
DOI:10.1111/j.1365-2958.2006.05331.x
Reference
PMID:16939780
  Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
  Title
Cell and molecular biology of the exosome: how to make or break an RNA.
  Journal
Int Rev Cytol 251:159-208 (2006)
DOI:10.1016/S0074-7696(06)51005-8
Reference
PMID:17471261
  Authors
Hartung S, Hopfner KP
  Title
The exosome, plugged.
  Journal
EMBO Rep 8:456-7 (2007)
DOI:10.1038/sj.embor.7400961
Reference
PMID:17447862
  Authors
Carpousis AJ
  Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
  Journal
Annu Rev Microbiol 61:71-87 (2007)
DOI:10.1146/annurev.micro.61.080706.093440
Reference
PMID:16766188
  Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
  Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
  Journal
Trends Biochem Sci 31:359-65 (2006)
DOI:10.1016/j.tibs.2006.05.005
Reference
PMID:17560162
  Authors
Condon C
  Title
Maturation and degradation of RNA in bacteria.
  Journal
Curr Opin Microbiol 10:271-8 (2007)
DOI:10.1016/j.mib.2007.05.008
Related
pathway
maua03015  mRNA surveillance pathway
KO pathway
ko03018   
LinkDB

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