KEGG   PATHWAY: mdm00053
Entry
mdm00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Malus domestica (apple)
Class
Metabolism; Carbohydrate metabolism
Pathway map
mdm00053  Ascorbate and aldarate metabolism
mdm00053

Module
mdm_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:mdm00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Malus domestica (apple) [GN:mdm]
Gene
103402836  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
103431642  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
103420358  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
103424555  UDP-glucose 6-dehydrogenase 4-like isoform X2 [KO:K00012] [EC:1.1.1.22]
103456258  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
103404258  glucuronokinase 1 isoform X1 [KO:K16190] [EC:2.7.1.43]
103442205  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
103400740  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
103449904  inositol oxygenase 4-like [KO:K00469] [EC:1.13.99.1]
103439079  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
103403438  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
103439059  inositol oxygenase 1-like isoform X1 [KO:K00469] [EC:1.13.99.1]
103413788  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
103413791  LOW QUALITY PROTEIN: NADPH-dependent aldo-keto reductase, chloroplastic [KO:K00002] [EC:1.1.1.2]
103430606  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
103450275  LOW QUALITY PROTEIN: NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
103450273  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
103433453  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
103433458  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
103403436  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
103450272  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
103441169  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
103420706  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
103415463  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
103434065  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
103434162  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
103430505  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
103408656  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
103446110  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
103448375  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
103427292  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
103434428  inositol monophosphatase 1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
103422491  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
103410485  bifunctional phosphatase IMPL2, chloroplastic-like isoform X2 [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
103412081  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
103436244  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
103423291  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
103435476  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
103439653  UDP-glucuronate 4-epimerase 4-like [KO:K08679] [EC:5.1.3.6]
103443417  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
103415098  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
103418498  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
103428058  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
103425033  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
103403490  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
103403467  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
114820654  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
103453944  monodehydroascorbate reductase-like [KO:K08232] [EC:1.6.5.4]
103411764  monodehydroascorbate reductase, chloroplastic/mitochondrial isoform X2 [KO:K08232] [EC:1.6.5.4]
103430138  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
103404333  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
103433944  monodehydroascorbate reductase, seedling isozyme-like [KO:K08232] [EC:1.6.5.4]
114820098  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
103447832  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
103456198  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
103412451  LOW QUALITY PROTEIN: L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
103456150  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
103441493  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
103407746  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
103410608  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
103413735  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
103415927  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
103415928  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
103428850  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
103413542  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
103432300  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103433463  DHAR; glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103435916  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103444197  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103448151  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
103437331  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103423174  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103437332  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
114819401  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103449962  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
103451955  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
103401714  aldehyde dehydrogenase family 3 member H1-like isoform X2 [KO:K00128] [EC:1.2.1.3]
103401089  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
103437735  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
103400942  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
103431162  aldehyde dehydrogenase family 2 member B4, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
103428851  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
103400922  MF-60; aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103406954  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
mdm00020  Citrate cycle (TCA cycle)
mdm00040  Pentose and glucuronate interconversions
mdm00051  Fructose and mannose metabolism
mdm00520  Amino sugar and nucleotide sugar metabolism
mdm00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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