KEGG   PATHWAY: mdo04814
Entry
mdo04814                    Pathway                                
Name
Motor proteins - Monodelphis domestica (gray short-tailed opossum)
Class
Cellular Processes; Cell motility
Pathway map
mdo04814  Motor proteins
mdo04814

Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100022120  DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
100011216  DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
100018115  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
100014648  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
100025134  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
100033374  DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417]
100018529  DYNLL1; dynein light chain LC8-type 1 [KO:K10418]
100011424  DYNLL2; dynein light chain LC8-type 2 [KO:K10418]
100021555  dynein light chain 1, cytoplasmic-like [KO:K10418]
100032367  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
100012584  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
100027715  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
100029346  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
100619847  dynein light chain Tctex-type 3-like [KO:K10420]
100032672  TCTE3; t-complex-associated-testis-expressed 3 [KO:K25419]
103103883  TCTEX1D4; Tctex1 domain containing 4 [KO:K25420]
100030873  TCTEX1D1; Tctex1 domain containing 1 [KO:K25421]
100015159  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
100026476  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
100030966  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
100029525  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
100020164  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
100030590  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
100031475  DNAH9; dynein axonemal heavy chain 9 [KO:K10408]
100017191  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
100616881  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
100029746  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
100024148  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
100031028  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
100619178  DNAH14; dynein axonemal heavy chain 14 [KO:K10408]
100028940  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
100028224  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
100012128  WDR63; WD repeat domain 63 [KO:K24722]
100030866  WDR78; WD repeat domain 78 [KO:K24723]
100031703  DNALI1; dynein axonemal light intermediate chain 1 [KO:K10410]
100024430  DNAL1; dynein axonemal light chain 1 [KO:K10411]
100013204  DNAL4; dynein axonemal light chain 4 [KO:K10412]
100017556  DCTN1; dynactin subunit 1 [KO:K04648]
100028844  DCTN3; dynactin subunit 3 [KO:K10425]
100024259  DCTN4; dynactin subunit 4 [KO:K10426]
100019570  DCTN5; dynactin subunit 5 [KO:K10427]
100020238  DCTN6; dynactin subunit 6 [KO:K10428]
100022923  ACTR1A; ARP1 actin-related protein 1 homolog A, centractin alpha [KO:K16575]
100024757  ACTR1B; ARP1 actin-related protein 1 homolog B, centractin beta [KO:K16575]
100021105  ACTR10; actin-related protein 10 homolog [KO:K16576]
100030578  CAPZA1; capping actin protein of muscle Z-line alpha subunit 1 [KO:K10364]
780952  CAPZA2; capping actin protein of muscle Z-line alpha subunit 2 [KO:K10364]
103098152  CAPZA3; capping actin protein of muscle Z-line alpha subunit 3 [KO:K10364]
100027610  CAPZB; capping actin protein of muscle Z-line beta subunit [KO:K10365]
100014780  BICDL2; BICD family like cargo adaptor 2 [KO:K16756]
103093319  BICDL1; BICD family like cargo adaptor 1 [KO:K16756]
100030243  HOOK3; hook microtubule tethering protein 3 [KO:K16536]
100010238  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100010347  TUBA1B; tubulin alpha 1b [KO:K07374]
100010481  tubulin alpha-1D chain [KO:K07374]
100015203  tubulin alpha-8 chain [KO:K07374]
100022210  TUBA8; tubulin alpha 8 [KO:K07374]
100025645  TUBA3E; tubulin alpha 3e [KO:K07374]
100010436  TUBA1A; tubulin alpha-1 chain [KO:K07374]
100014040  TUBB6; tubulin beta 6 class V [KO:K07375]
100018067  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
100021036  TUBB2B; tubulin beta 2B class IIb [KO:K07375]
100021064  TUBB2A; tubulin beta-2A chain [KO:K07375]
100022562  TUBB; tubulin beta class I [KO:K07375]
100027039  TUBB1; tubulin beta 1 class VI [KO:K07375]
100027632  TUBB3; tubulin beta 3 class III [KO:K07375]
100024672  tubulin beta chain-like [KO:K07375]
100025951  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
100010939  tubulin gamma-1 chain [KO:K10389]
100011615  tubulin gamma-1 chain-like [KO:K10389]
100010307  TUBD1; tubulin delta 1 [KO:K10390]
100029492  TUBE1; tubulin epsilon 1 [KO:K10391]
100013478  KIF5C; kinesin family member 5C [KO:K10396]
100023318  KIF5B; kinesin family member 5B [KO:K10396]
100010999  KLC4; kinesin light chain 4 [KO:K10407]
100016881  KLC1; kinesin light chain 1 [KO:K10407]
100029750  KLC2; kinesin light chain 2 [KO:K10407]
100018884  KIF3A; kinesin family member 3A [KO:K10394]
100009961  KIF3B; kinesin family member 3B [KO:K20196]
100019890  KIFAP3; kinesin associated protein 3 [KO:K25388]
100025498  KIF3C; kinesin family member 3C [KO:K20197]
100027010  KIF17; kinesin family member 17 [KO:K20198]
100017660  KIF1C; kinesin family member 1C [KO:K10392]
100013596  KIF1A; kinesin family member 1A [KO:K10392]
100618880  KIF1B; kinesin family member 1B [KO:K10392]
100025300  KIF13A; kinesin family member 13A [KO:K17914]
100033160  KIF13B; kinesin family member 13B [KO:K17914]
100027148  KIF14; kinesin family member 14 [KO:K17915]
100033264  KIF16B; kinesin family member 16B [KO:K17916]
103096165  STARD9; StAR related lipid transfer domain containing 9 [KO:K16491]
100014076  KIF4A; kinesin family member 4A [KO:K10395]
100617418  KIF7; kinesin family member 7 [KO:K18806]
100023746  KIF21A; kinesin family member 21A [KO:K24185]
100013603  KIF21B; kinesin family member 21B [KO:K24185]
100029495  KIF27; kinesin family member 27 [KO:K24186]
100023994  KIF11; kinesin family member 11 [KO:K10398]
100019879  KIF20A; kinesin family member 20A [KO:K10402]
100024800  KIF20B; kinesin family member 20B [KO:K10402]
100617570  KIF23; kinesin family member 23 [KO:K17387]
100013897  CENPE; centromere protein E [KO:K11498]
100030832  KIF18A; kinesin family member 18A [KO:K10401]
100023998  KIF18B; kinesin family member 18B [KO:K26156]
100028208  KIF19; kinesin family member 19 [KO:K26157]
100029348  kinesin-like protein KIF19 [KO:K26157]
100029793  KIF6; kinesin family member 6 [KO:K10397]
100024792  KIF9; kinesin family member 9 [KO:K10397]
100013735  KIF22; kinesin family member 22 [KO:K10403]
100026930  KIF26B; kinesin family member 26B [KO:K10404]
103095292  KIF26A; kinesin family member 26A [KO:K10404]
100009978  KIF12; kinesin family member 12 [KO:K10399]
100029685  KIF15; kinesin family member 15 [KO:K10400]
100032333  KIF2A; kinesin family member 2A [KO:K10393]
100015249  KIF2B; kinesin family member 2B [KO:K10393]
554240  KIF24; kinesin family member 24 [KO:K10393]
100014033  KIF2C; kinesin family member 2C [KO:K10393]
100027350  KIFC1; kinesin family member C1 [KO:K10405]
100019241  KIFC2; kinesin family member C2 [KO:K10406]
100618098  KIFC3; kinesin family member C3 [KO:K10406]
100032643  KIF25; kinesin family member 25 [KO:K18627]
100017174  MYO1C; myosin IC [KO:K10356]
100018490  MYO1D; myosin ID [KO:K10356]
100021672  MYO1B; myosin IB [KO:K10356]
100023829  MYO1G; myosin IG [KO:K10356]
100025227  MYO1F; myosin IF [KO:K10356]
100028516  MYO1H; myosin IH [KO:K10356]
100616884  MYO1E; myosin IE [KO:K10356]
100011557  MYO1A; myosin IA [KO:K10356]
100024555  MYO3B; myosin IIIB [KO:K08834] [EC:2.7.11.1]
100025094  MYO3A; myosin IIIA [KO:K08834] [EC:2.7.11.1]
100020194  MYO5B; myosin VB [KO:K10357]
100031389  MYO5C; myosin VC [KO:K10357]
100031404  MYO5A; myosin VA [KO:K10357]
100016804  MYO6; myosin VI [KO:K10358]
100027725  MYO7A; myosin VIIA [KO:K10359]
100026576  MYO7B; myosin VIIB [KO:K21868]
100015851  MYO9B; myosin IXB [KO:K10360]
100013745  MYO9A; myosin IXA [KO:K10360]
100021248  MYO10; myosin X [KO:K12559]
100029476  MYO15A; myosin XVA [KO:K10361]
103094957  unconventional myosin-XVB-like [KO:K10361]
100024462  MYO16; myosin XVI [KO:K17481]
100010514  MYO18B; myosin XVIIIB [KO:K10362]
100616706  MYO18A; myosin XVIIIA [KO:K10362]
100016858  MYO19; myosin XIX [KO:K25838]
100027344  MYH1; myosin-1 [KO:K24220]
100027367  MYH2; myosin-2 [KO:K24220]
100027388  MYH3; myosin-3 [KO:K24220]
100027326  MYH4; myosin-4 [KO:K24220]
100027255  MYH13; myosin-13 [KO:K24220]
100027290  MYH8; myosin-8 [KO:K24220]
100024758  MYH7; myosin heavy chain 7 [KO:K17751]
100030608  MYH6; myosin heavy chain 6 [KO:K17751]
100012731  MYH10; myosin heavy chain 10 [KO:K10352]
100016741  MYH11; myosin heavy chain 11 [KO:K10352]
100024892  MYH9; myosin heavy chain 9 [KO:K10352]
100013093  MYL1; myosin light chain 1 [KO:K05738]
100018980  MYL3; myosin light chain 3 [KO:K12749]
100021133  MYL4; myosin light chain 4 [KO:K12750]
100019715  MYL2; myosin light chain 2 [KO:K10351]
100027358  MYL5; myosin light chain 5 [KO:K12753]
100030115  MYL7; myosin light chain 7 [KO:K12754]
100028971  MYL9; myosin light chain 9 [KO:K12755]
100028046  MYL10; myosin light chain 10 [KO:K12756]
100012236  myosin regulatory light polypeptide 9 [KO:K12757]
100012278  MYL12B; myosin light chain 12B [KO:K12757]
100017537  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
100022118  ACTA1; actin, alpha 1, skeletal muscle [KO:K10354]
100014836  actin, alpha skeletal muscle 3-like [KO:K10354]
100012397  ACTA2; actin, alpha 2, smooth muscle, aorta [KO:K12313]
100017854  actin-like [KO:K12313]
100026925  ACTC1; actin, alpha, cardiac muscle 1 [KO:K12314]
100012779  ACTG2; actin, gamma 2, smooth muscle, enteric [KO:K12315]
100025924  ACTG1; actin gamma 1 [KO:K05692]
100029767  actin, cytoplasmic type 5 [KO:K05692]
100011313  actin, cytoplasmic 1 [KO:K05692]
100016601  actin, cytoplasmic 1-like [KO:K05692]
100020439  actin, cytoplasmic 1-like [KO:K05692]
100024060  actin, cytoplasmic 1-like [KO:K05692]
100028958  actin, cytoplasmic 1-like [KO:K05692]
103096124  actin, cytoplasmic 1-like [KO:K05692]
100011351  ACTB; actin beta [KO:K05692]
100020553  TNNC1; troponin C1, slow skeletal and cardiac type [KO:K05865]
100014100  TNNI1; troponin I1, slow skeletal type [KO:K10371]
100032910  TNNT1; troponin T1, slow skeletal type [KO:K10372]
100021819  TNNC2; troponin C2, fast skeletal type [KO:K12042]
100032908  TNNI3; troponin I3, cardiac type [KO:K12044]
100013928  TNNT2; troponin T2, cardiac type [KO:K12045]
100016737  TPM1; tropomyosin 1 (alpha) [KO:K10373]
100020343  TPM2; tropomyosin 2 (beta) [KO:K10374]
100015402  TPM3; tropomyosin 3 [KO:K09290]
100617065  TPM4; tropomyosin 4 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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