KEGG ORTHOLOGY: K12314

ORTHOLOGY: K12314

Entry

K12314                      KO

Symbol

ACTC1

Name

actin, alpha cardiac muscle

Pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00292

Hypertrophic cardiomyopathy

H00294

Dilated cardiomyopathy

H00546

Atrial septal defect

H01216

Left ventricular noncompaction

H01219

Restrictive cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K12314  ACTC1; actin, alpha cardiac muscle
   04261 Adrenergic signaling in cardiomyocytes
    K12314  ACTC1; actin, alpha cardiac muscle
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K12314  ACTC1; actin, alpha cardiac muscle
   05414 Dilated cardiomyopathy
    K12314  ACTC1; actin, alpha cardiac muscle
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K12314  ACTC1; actin, alpha cardiac muscle
   04147 Exosome
    K12314  ACTC1; actin, alpha cardiac muscle
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     K12314  ACTC1; actin, alpha cardiac muscle
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K12314  ACTC1; actin, alpha cardiac muscle
  Exosomal proteins of bladder cancer cells
   K12314  ACTC1; actin, alpha cardiac muscle

Genes

HSA:

70(ACTC1)

PTR:	453307(ACTC1)

PPS:

100987752

GGO:	101150071(ACTC1)

PON:

100442237

NLE:	100603570(ACTC1)

HMH:	116481842(ACTC1)

MCC:	697367(ACTC1)

MCF:	102135975(ACTC1)

MTHB:

126958845

MNI:	105492919(ACTC1)

CSAB:

103245896(ACTC1)

CATY:

105574124(ACTC1)

PANU:

101020447(ACTC1)

TGE:	112627532(ACTC1)

MLEU:

105548603(ACTC1)

RRO:	104665644(ACTC1)

RBB:	108543689(ACTC1)

TFN:	117070916(ACTC1)

PTEH:

111554612(ACTC1)

CANG:

105505005(ACTC1)

CJC:	100398865(ACTC1)

SBQ:	101037742(ACTC1)

CIMI:

108311889(ACTC1)

CSYR:

103268331(ACTC1)

MMUR:

105872390(ACTC1)

LCAT:

123621825(ACTC1)

PCOQ:

105814487(ACTC1)

OGA:	100943877(ACTC1)

MMU:	11464(Actc1)

MCAL:

110308886(Actc1)

MPAH:

110317581(Actc1)

RNO:	29275(Actc1)

MCOC:

116090660(Actc1)

ANU:	117702973(Actc1)

MUN:	110555967(Actc1)

CGE:	100766388(Actc1)

MAUA:

101824839(Actc1)

PROB:

127221770(Actc1)

PLEU:

114697505(Actc1)

MORG:

121465679(Actc1)

MFOT:

126495089

AAMP:

119815907(Actc1)

NGI:	103740516(Actc1)

HGL:	101723544(Actc1)

CPOC:

100731953(Actc1)

CCAN:

109677781(Actc1)

DORD:

105981033

DSP:	122114665(Actc1)

NCAR:

124971702

OCU:

100340339

OPI:	101524138(ACTC1)

TUP:	102486241(ACTC1)

GVR:

103606831

CFA:	478250(ACTC1)

CLUD:

112676179(ACTC1)

VVP:	112919920(ACTC1)

VLG:	121484876(ACTC1) 121488685

AML:	100464234(ACTC1)

UMR:	103673559(ACTC1) 103679895

UAH:	113242071(ACTC1)

UAR:	123776450(ACTC1)

ELK:

111158552

LLV:

125105260

MPUF:

101684977(ACTC1)

NVS:	122893521(ACTC1)

ORO:	101383699(ACTC1)

EJU:	114221336(ACTC1)

ZCA:	113910477(ACTC1)

MLX:	118003185(ACTC1)

NSU:	110585162(ACTC1)

LWW:	102730313(ACTC1) 102731551

FCA:	101095586(ACTC1)

PYU:	121041457(ACTC1)

PBG:	122468819(ACTC1)

LRUF:

124508107

PTG:	102958158(ACTC1)

PPAD:

109263206(ACTC1)

PUC:

125909814

AJU:	106969798(ACTC1)

HHV:	120241888(ACTC1)

BTA:	533219(ACTC1)

BOM:	102266730(ACTC1)

BIU:	109564901(ACTC1)

BBUB:

102402622(ACTC1)

BBIS:

104991631(ACTC1)

CHX:	102170606(ACTC1)

OAS:	101111554(ACTC1)

ODA:	120853247(ACTC1) 120867442

CCAD:

122443347(ACTC1)

SSC:	100152267(ACTC1)

CFR:	102524504(ACTC1)

CBAI:

105076871(ACTC1)

CDK:	105089985(ACTC1)

VPC:	102536147(ACTC1) 102544879(ACTA1)

BACU:

103001576(ACTC1)

LVE:	103074529(ACTC1)

OOR:	101287649(ACTC1)

DLE:	111181781(ACTC1)

PCAD:

102996486(ACTC1)

PSIU:

116749865(ACTC1)

NASI:

112391190(ACTC1)

ECB:	100057678(ACTC1)

EPZ:	103549173(ACTC1)

EAI:	106835151(ACTC1)

MYB:	102247353(ACTC1)

MYD:	102763375(ACTC1)

MMYO:

118649467(ACTC1)

MLF:	102435405(ACTC1)

MNA:	107543021(ACTC1)

PKL:	118723947(ACTC1)

HAI:	109386250(ACTC1)

DRO:	112311247(ACTC1)

SHON:

118993629(ACTC1)

AJM:	119040247(ACTC1)

PDIC:

114491619(ACTC1)

PHAS:

123808170(ACTC1)

MMF:	118620606(ACTC1)

RFQ:	117024179(ACTC1)

PALE:

102880535(ACTC1)

PGIG:

120587219(ACTC1)

PVP:	105288607(ACTC1)

RAY:	107508080(ACTC1)

MJV:

108396706

TOD:	119237896(ACTC1)

SARA:

101546466(ACTC1)

LAV:	100658146(ACTC1)

TMU:

101341415

ETF:	101652118(ACTC1)

DNM:	101443467(ACTC1)

MDO:	100026925(ACTC1)

GAS:	123235979(ACTC1) 123254541

SHR:	100918763(ACTC1)

AFZ:

127549197

PCW:	110214160(ACTC1)

OAA:	100086207(ACTC1) 100088994

GGA:	423298(ACTC1) 426652(ACTBL2L)

PCOC:

116229100 116229330(ACTC1)

MGP:	100303693 100541147

CJO:	107311421(ACTA1) 107314384 107314994(ACTC1)

NMEL:

110400816(ACTC1) 110401710

APLA:

101792025(ACTC1) 101803316

ACYG:

106031717(ACTC1) 106044622

AFUL:

116490045 116490308(ACTC1)

TGU:	100229664(ACTC1)

LSR:	110475286(ACTC1)

SCAN:

103826575(ACTC1)

PMOA:

120500352(ACTC1)

OTC:	121331502(ACTC1)

PRUF:

121362526

GFR:	102038037(ACTC1)

FAB:	101808145(ACTC1)

PHI:	102099989(ACTC1)

PMAJ:

107206305(ACTC1)

CCAE:

111942704

CCW:	104684380(ACTC1)

CBRC:

103620831(ACTC1)

ETL:	114055305(ACTC1)

ZAB:	102067828(ACTC1)

ACHL:

103798007

SVG:	106862468(ACTC1)

FPG:	101914921(ACTC1) 101915966

FCH:	102050360(ACTC1) 102051901

CLV:	102084489 102093431(ACTC1)

EGZ:	104126475(ACTC1)

NNI:	104009401 104015900(ACTC1)

PLET:

104615515 104616853

PCRI:

104025962 104031825 104033361

PCAO:

104042630 104046926

ACUN:

113480547(ACTC1) 113481280

TALA:

104363846(ACTC1) 104364034

PADL:

103921934(ACTC1) 103925776

AFOR:

103904992 103908048(ACTC1)

ACHC:

115335583(ACTC1) 115352224

HALD:

104320391 104325481

HLE:	104829436 104835950(ACTC1)

AGEN:

126046808 126049381

GCL:	127016508 127016582

CCRI:

104156113 104159708

CSTI:

104562459

EHS:	104506634 104514298

CMAC:

104474231 104474300

MUI:

104542631

FGA:	104071454 104084426

GSTE:

104251775 104259123

LDI:	104350763 104353957

MNB:

103776397

OHA:	104338997(ACTC1)

NNT:	104404810(ACTA1) 104406869

SHAB:

115606000 115606898(ACTC1)

DPUB:

104310285(ACTC1)

PGUU:

104459047 104468155

ACAR:

104518948 104522967

CPEA:

104397700(ACTC1)

AVIT:

104279614

CVF:	104288164(ACTC1)

CUCA:

104064868(ACTC1)

TEO:	104370607 104370627

BRHI:

104502241

AAM:	106482816(ACTC1) 106498226

AROW:

112970906(ACTC1) 112977262

NPD:	112943475 112958082(ACTC1)

TGT:	104564432(ACTC1) 104567934

DNE:	112979618(ACTC1) 112983091

SCAM:

104145942(ACTC1) 104152862

ASN:	102373984 102375012

AMJ:	102570695 106736711(ACTC1)

CPOO:

109308415(ACTRT3) 109321048 109321560(ACTC1)

GGN:	109287959(ACTRT3) 109298700(ACTC1) 109298981

PSS:	102450720 102456632

CMY:	102931639 102939680(ACTC1)

CPIC:

101941415 101944575(ACTC1)

TST:	117876655(ACTC1) 117877029

CABI:

116821643(ACTC1) 116825210

MRV:	120402762 120405035(ACTC1)

ACS:	100560364(actc1) 100564866 100566451

PVT:	110073536 110076864(ACTC1) 110085534

SUND:

121915179 121918273(ACTC1) 121930529

PBI:	103048247 103056625 103065681

PMUR:

107299881 107299889

CTIG:

120304881(ACTC1) 120314109

TSR:

106552958

PGUT:

117665444 117665724(ACTC1)

VKO:	123026375 123026633(ACTC1)

PMUA:

114587228 114593238(ACTC1) 114596644

ZVI:	118075728 118082603(ACTC1) 118085804

GJA:	107118263 107121602

STOW:

125426159(ACTC1) 125441438

XLA:	108699710(actc1.S) 108716753(acta1.L) 379351(MGC75582.L) 379752(actc1.L) 432314(acta1.S) 779096(acta4.L) 779129(MGC75582.S)

XTR:	394673(acta4) 394698(actc1) 394982(MGC75582) 448346(acta1)

NPR:	108793897 108794424 108800042 108800760

RTEM:

120920821(ACTC1) 120937454 120937456 120938933

BBUF:

120981786(ACTC1) 120988887 120997871(ACTRT3) 120998599

BGAR:

122921503(ACTC1) 122924331 122933741(ACTRT3) 122934088

DRE:	337770(si:ch73-187m15.4) 408256(actc1a) 415164(acte1) 550445(acta1a) 570210(actc2) 58114(actc1b)

SRX:	107707500 107712442 107714084 107721305 107740296 107745353 107756589

SANH:

107654103 107664814 107668140 107668229 107674972 107678759 107687214 107693795

SGH:	107549100 107549542 107572152 107589168 107594158 107598132 107601891

CCAR:

109052669 109058221 109080038 109082580 109108280 109113560

CAUA:

113043728 113057006 113063012 113063117 113063129 113066811 113068199 113068205 113072543 113078190 113096599 113117808 113120874 113121127 113121180

CGIB:

127933287 127938823 127938914 127947436 127949120 127970770 127976778 127983981 127984180 128014725 128020021 128026230

PPRM:

120460348(acte1) 120477686(actc1b) 120480042(acta1b) 120488726(acta1a) 120493795(actc1a) 120494120(actc2)

MAMB:

125247186(acte1) 125269229(actc1b) 125271770(acta1a) 125276877(acta1b) 125277823(actc1a) 125279027(actc2)

CIDE:

127498899 127501809 127502701 127507577 127512561 127524410

MASI:

127410044 127410121 127410725 127411819 127414133 127416246 127416495 127435618 127437791 127444541 127455229

IPU:	108257679(actc2) 108258095(actc1a) 108258624(acta1a) 108264857 108269395(acte1) 108269850 124626966

PHYP:

113524817 113526557 113529562 113531857 113537359 113538705 113546513

SMEO:

124377101(actc2) 124377193(actc1a) 124378397(acta1a) 124385997(acte1) 124389968 124390080 124395545 124400632(acta1b)

TFD:	113636109(acte1) 113638829 113648008(actc2) 113655680(actc1a) 113660301(actc1b) 113661105(acta1b) 113663672(acta1a)

AMEX:

103024089 103025229 103031709 103031734 103039206 103042272 103042935 111196450

EEE:	113570535 113571346 113579635 113580113 113582053

TRU:	101062076 101069447(acta1a) 101072885 101074318 101077200 101080182(actc1)

TNG:	GSTEN00011952G001 GSTEN00022994G001 GSTEN00032002G001 GSTEN00032809G001

LCO:	104918508 104920157 104922409(actc1) 104926557 104931734

NCC:	104955598 104966012

CGOB:

115003500 115006214 115006217 115027279(actc1) 115027559 115028965

ELY:	117252602(acta1b) 117256023(acta1a) 117266627 117267022 117270614(actc1a)

EFO:	125885473(acta1a) 125896641(actc1a) 125899329(acta1b) 125900374 125900378

PLEP:

121942312(acta1a) 121951369(acta1b) 121953212 121953743 121955164(actc1a)

SLUC:

116035720 116049845(acta1a) 116057592 116060522(acta1b) 116066187(actc1a)

ECRA:

117935922 117953779(acta1b) 117961217(actc1a) 117962125(acta1a)

ESP:	116670252 116670704(actc1) 116687960 116689506 116705930

PFLV:

114546443 114546752(actc1) 114547979 114548473 114573063

GAT:	120808226 120811837(acta1b) 120832566 120833408

PPUG:

119195173(actc1a) 119196063(acta1b) 119227458 119227655

MSAM:

119890821(acta1b) 119896821 119898218(acta1a) 119909244(actc1a) 119909895

CUD:	121508155(acta1a) 121510138(acta1b) 121521277(actc1a) 121526002 121526107

ALAT:

119004434 119005037 119012285(actc1a) 119013601(acta1a) 119018719(acta1b)

MZE:	101464265 101470161 101471995 101481306(actc1) 101487925

ONL:	100534411 100534413 100694494(actc1) 100706681 100712462

OAU:	116311282(actc1a) 116313239(acta1b) 116321490(acta1a) 116322369 116326097

OLA:	100049431(acta1) 101159887 101161456 101170382

OML:	112138110(acta1a) 112144614 112157710(actc1a) 112161115(acta1b)

XMA:	102225200 102227614 102230365(actc1) 102233599

XCO:	114133993 114134391(actc1) 114143458(acta1) 114159161

XHE:	116708901(actc1) 116709089 116718741(acta1) 116734748

PRET:

103457336 103458530 103458759(actc1) 103462807(acta1)

PFOR:

103136121 103136490(acta1) 103154821(actc1) 103156675

PLAI:

106949430 106959002(acta1) 106959035 106961437(actc1)

PMEI:

106906445(actc1) 106907938 106915026 106924149(acta1)

GAF:	122824882(actc1a) 122842308(acta1b) 122846001 122846687

CVG:	107084063 107092155(acta1) 107094549

CTUL:

119778341 119787488 119789624(acta1b)

GMU:	124867557(acta1b) 124881790(actc1a) 124884866

NFU:	107377808 107381193(acta1) 107392170(actc1) 107392454

KMR:	108233466(actc1a) 108234028 108235814 108237352(acta1b)

ALIM:

106513136 106520111 106522422 106531354

NWH:	119418606(actc1a) 119422625(acta1a) 119423215(acta1b) 119427281 119427288

AOCE:

111562555 111570292 111573261(actc1) 111575667 111586900 111587057

MCEP:

124998701(actc1a) 125003702(acta1a) 125005141(acta1b) 125023487 125023714

CSEM:

103378615 103378761 103381182 103383882 103386973 103391372

POV:	109628044 109636065 109636843 109646190 109647272

SSEN:

122772298(acta1b) 122782779 122782840 122784046(actc1a)

HHIP:

117753815(acta1b) 117756580 117756773 117758333(actc1a) 117764434(acta1a)

HSP:	118099232(acta1a) 118099240(actc1a) 118103330(acta1b) 118115892 118116146

LCF:	108875000 108876896(acta1b) 108882509(acta1a) 108887244 108892514

SDU:	111216472 111217992 111225976 111226209(actc1) 111238236

SLAL:

111648972 111650685 111661457 111668859 111673256

XGL:	120788983(actc1a) 120795307 120795337 120800720(acta1a) 120804960(acta1b)

HCQ:	109507758 109516306 109517465(actc1) 109531543

SSCV:

125966802 125980381 125980629 125990104

BPEC:

110155223 110156395 110172824

MALB:

109951638 109954531 109962396 109974803

BSPL:

114848006 114848937 114849506(actc1a) 114852400(acta1b)

SASA:

100194557 106561611 106571104 106571646 106573099 106601553(actc1) 106608170 106608259 106610845

STRU:

115152353 115152854 115157012 115161672 115162374 115172438(actc1) 115172654 115174584 115175121 115178705 115197599 115201473 115208722

OTW:	112217913 112217949(actc1a) 112218885 112235643 112252672(acte1) 112256654 112261625 112261825

OMY:	110497758 110498364 110499906 110505499 110522536 110522582(actc1a) 110524558(acte1) 110529317

OGO:	123990513 123995361 123995401(actc1a) 124001296 124001789 124004062(acte1) 124004360 124015067 124033262 124039571 124040258 124046426

ONE:	115107517 115109682 115112847 115124047 115131447 115138467 115139148 115142494 115142495 115144313 115145380 115146082(actc1)

SALP:

111952750 111954389 111962756 111963243 111968583(actc1) 111968769 111973043 112070447 112070495

SNH:	120019159 120019188 120023079 120023887(actc2) 120024614 120029579 120032577 120046830 120054163(acte1) 120060236 120060395 120066345 120066369

CCLU:

121531647 121539245 121544770 121544945 121547615 121548516 121548560 121552813 121561304 121577043 121577954 123486571

ELS:	105015494(actc1) 105015666 105017577 105018274 105021204 105021500 105024319

SFM:	108924075 108928298 108932839(acta1) 108941121

PKI:	111838863 111841594 111841768 111855084(acta1)

AANG:

118210600 118210959 118215310 118217623 118218176 118226726 118230674

LOC:	102684028(acta1) 102685048(actc1) 102688628 102689871

PSPA:

121295041 121316038 121317153 121324248 121324506(actc1a) 121329870 121329947 121329983

ARUT:

117397907 117402814 117411538 117418419 117419276 117422419 117422629 117432207 117434966

PSEX:

120518305 120525714 120538919

LCM:	102352337(ACTC1) 102362273 102364634

CMK:	103175184(actc1) 103180967

RTP:	109925418 109927506

CPLA:

122544463 122553748

BFO:	118429843 118429844 118429845 118429846 118429849 118429855

BBEL:

109479779 109479780 109479781 109479816

CIN:	100176797 100182007 100183636 100185123 100186048 101243473 104265362

SCLV:

120326129 120327489 120328101 120328494 120328495 120331462 120331632 120331731 120331732 120331733 120331736 120333695 120335717 120338943 120339878 120342095 120342130 120342525 120346652

AGS:

114120988

RMD:

113557908

PVM:	113815139 113818736 113819259 113819260 113819262 113819263 113819264 113819266 113819268 113819269 113819270

PJA:	122243773 122250387 122250405 122250406 122250407 122250409 122250410 122250411 122250412 122250413 122250414 122250415 122250422 122250423 122257641 122257647 122259288 122259292 122265510