KEGG   PATHWAY: mju04141
Entry
mju04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Maniola jurtina (meadow brown)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mju04141  Protein processing in endoplasmic reticulum
mju04141

Other DBs
GO: 0030433 0034976
Organism
Maniola jurtina (meadow brown) [GN:mju]
Gene
123866573  protein transport protein Sec61 subunit alpha [KO:K10956]
123867391  protein transport protein Sec61 subunit beta [KO:K09481]
123866506  protein transport protein Sec61 subunit gamma [KO:K07342]
123872718  translocation protein SEC62 [KO:K12275]
123866629  translocation protein SEC63 homolog [KO:K09540]
123876215  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
123875795  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
123881151  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
123864372  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151] [EC:2.4.99.18]
123874919  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
123865887  tumor suppressor candidate 3 [KO:K19478]
123866645  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
123868786  transmembrane protein 258 [KO:K26502]
123878321  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
123873039  hypoxia up-regulated protein 1 [KO:K09486]
123864930  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
123881306  dnaJ homolog shv [KO:K09517]
123881250  uncharacterized protein F54F2.9 [KO:K09521]
123864112  dnaJ homolog subfamily C member 3 [KO:K09523]
123878221  neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
123869059  glucosidase 2 subunit beta [KO:K08288]
123865896  calnexin [KO:K08054]
123870922  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
123866870  calreticulin [KO:K08057]
123867829  mannosyl-oligosaccharide alpha-1,2-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
123880011  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
123877902  vesicular integral-membrane protein VIP36 [KO:K10082]
123879165  protein ERGIC-53 [KO:K10080]
123864717  prolactin regulatory element-binding protein [KO:K14003]
123867463  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
123875361  protein SEC13 homolog [KO:K14004]
123873588  protein transport protein Sec31A isoform X1 [KO:K14005]
123875331  protein transport protein Sec23A isoform X1 [KO:K14006]
123866822  protein transport protein Sec24A isoform X1 [KO:K14007]
123877195  protein transport protein Sec24D isoform X1 [KO:K14007]
123864282  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
123866239  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
123880249  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
123868300  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
123876242  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
123871065  protein windbeutel [KO:K09586]
123869204  thioredoxin domain-containing protein 5 homolog isoform X1 [KO:K13984] [EC:5.3.4.1]
123880894  ero1-like protein isoform X1 [KO:K10950] [EC:1.8.4.-]
123869711  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
123868507  translocon-associated protein subunit alpha [KO:K13249]
123875494  translocon-associated protein subunit beta [KO:K13250]
123872778  translocon-associated protein subunit gamma [KO:K13251]
123878386  translocon-associated protein subunit delta [KO:K04571]
123874510  B-cell receptor-associated protein 31-like [KO:K14009]
123872430  B-cell receptor-associated protein 31 [KO:K14009]
123875124  translocating chain-associated membrane protein 1 [KO:K14010]
123865259  derlin-1 [KO:K11519]
123872463  derlin-2 [KO:K13989]
123879214  UBX domain-containing protein 4 isoform X1 [KO:K24348]
123869287  UBX domain-containing protein 1-B [KO:K24348]
123865285  UBX domain-containing protein 6 [KO:K14011]
123865470  NSFL1 cofactor p47 [KO:K14012]
123877047  uncharacterized protein LOC123877047 [KO:K14014]
123875645  transitional endoplasmic reticulum ATPase TER94 isoform X1 [KO:K13525]
123871677  nuclear protein localization protein 4 homolog [KO:K14015]
123871063  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
123866576  heat shock protein 68-like [KO:K03283]
123877166  heat shock protein 68-like [KO:K03283]
123867911  heat shock 70 kDa protein cognate 4 [KO:K03283]
123878823  heat shock protein 68-like [KO:K03283]
123879561  heat shock protein 70 B2-like isoform X1 [KO:K03283]
123869192  heat shock protein 68-like [KO:K03283]
123871256  heat shock protein 68-like [KO:K03283]
123867549  dnaJ homolog subfamily A member 1 [KO:K09502]
123866874  dnaJ homolog subfamily A member 2-like [KO:K09503]
123877233  dnaJ protein homolog 1 [KO:K09507]
123878365  dnaJ homolog subfamily B member 14 [KO:K09518]
123864488  dnaJ homolog subfamily C member 5 [KO:K09525]
123877165  heat shock protein 83 [KO:K04079]
123866387  97 kDa heat shock protein isoform X1 [KO:K09485]
123875714  BAG family molecular chaperone regulator 2 isoform X1 [KO:K09556]
123870679  hsp70-binding protein 1 [KO:K09562]
123875973  protein lethal(2)essential for life-like [KO:K09542]
123877182  protein lethal(2)essential for life-like [KO:K09542]
123877257  protein lethal(2)essential for life-like [KO:K09542]
123877258  protein lethal(2)essential for life-like [KO:K09542]
123877259  protein lethal(2)essential for life-like [KO:K09542]
123877261  protein lethal(2)essential for life-like [KO:K09542]
123877347  protein lethal(2)essential for life-like [KO:K09542]
123877409  protein lethal(2)essential for life-like [KO:K09542]
123877410  protein lethal(2)essential for life-like [KO:K09542]
123877989  protein lethal(2)essential for life-like [KO:K09542]
123879970  protein lethal(2)essential for life-like [KO:K09542]
123870749  protein lethal(2)essential for life-like [KO:K09542]
123870779  protein lethal(2)essential for life-like [KO:K09542]
123872390  protein lethal(2)essential for life-like [KO:K09542]
123870795  heat shock protein Hsp-12.2-like [KO:K09542]
123867742  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
123866851  phospholipase A-2-activating protein [KO:K14018]
123880869  UV excision repair protein RAD23 homolog A [KO:K10839]
123874519  ubiquilin-1 [KO:K04523]
123875734  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
123873838  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
123876896  eukaryotic translation initiation factor 2-alpha kinase-like isoform X1 [KO:K08860] [EC:2.7.11.1]
123865546  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123868262  activating transcription factor of chaperone isoform X1 [KO:K04374]
123877602  wolframin isoform X1 [KO:K14020]
123880640  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
123870172  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
123872050  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123869952  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
123864929  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
123873725  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
123868085  E3 ubiquitin-protein ligase MARCHF6 [KO:K10661] [EC:2.3.2.27]
123874758  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
123874311  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
123874674  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
123871460  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
123879797  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
123880496  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
123874764  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
123881071  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
123878846  selenoprotein S-like [KO:K14025]
123874857  protein sel-1 homolog 1 isoform X1 [KO:K14026]
123875790  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
123872131  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
123869683  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
123866146  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
123879050  cullin-1 [KO:K03347]
123866144  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
mju00510  N-Glycan biosynthesis
mju03050  Proteasome
mju03060  Protein export
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system