KEGG   PATHWAY: mlx04814
Entry
mlx04814                    Pathway                                
Name
Motor proteins - Mirounga leonina (Southern elephant seal)
Class
Cellular Processes; Cell motility
Pathway map
mlx04814  Motor proteins
mlx04814

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118002341  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
118013158  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
118012335  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
118020788  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
118023705  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
118002594  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
118008190  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
118024709  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
118018549  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
118026827  dynein light chain 1, cytoplasmic-like [KO:K10418]
118023833  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
118011400  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
118001845  dynein light chain Tctex-type 1 [KO:K10420]
118001967  dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
118009169  DYNLT3; dynein light chain Tctex-type 3 isoform X1 [KO:K10420]
118001828  tctex1 domain-containing protein 3 [KO:K25419]
118001891  tctex1 domain-containing protein 3 [KO:K25419]
118019501  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
118020209  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
118000035  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
118000080  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
118007925  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
118001218  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
118024210  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
118018313  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
118004905  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
118005003  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
118012659  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
118012873  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
118006201  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
117999170  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
118021291  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
118018151  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
118024310  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
118019210  DNAI3; WD repeat-containing protein 63 [KO:K24722]
118019297  DNAI4; LOW QUALITY PROTEIN: WD repeat-containing protein 78 [KO:K24723]
118019673  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
118002036  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
117998668  DNAL4; dynein light chain 4, axonemal [KO:K10412]
118007958  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
118008671  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
118018001  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
118006697  dynactin subunit 4 [KO:K10426]
118006818  DCTN4; dynactin subunit 4 [KO:K10426]
117999127  DCTN5; dynactin subunit 5 [KO:K10427]
118009998  DCTN6; dynactin subunit 6 [KO:K10428]
118008216  ACTR1B; beta-centractin [KO:K16575]
118025544  ACTR1A; alpha-centractin [KO:K16575]
118002312  ACTR10; actin-related protein 10 [KO:K16576]
118016853  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
118025470  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
118018996  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
118021011  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
118019936  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
118018534  BICD family-like cargo adapter 1 [KO:K16756]
118021745  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
118009910  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
118008882  tubulin alpha-1B chain [KO:K07374]
118008883  tubulin alpha-1A chain [KO:K07374]
118008885  TUBA1C; tubulin alpha-1C chain [KO:K07374]
118025829  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
118012024  tubulin alpha-4A chain [KO:K07374]
118014190  tubulin alpha-8 chain-like [KO:K07374]
117999803  tubulin alpha-3 chain-like [KO:K07374]
117999807  tubulin alpha-3 chain [KO:K07374]
118021622  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118023396  tubulin beta-3 chain [KO:K07375]
118016456  TUBB6; tubulin beta-6 chain [KO:K07375]
118024014  TUBB1; tubulin beta-1 chain [KO:K07375]
118017483  TUBB4B; tubulin beta-4B chain [KO:K07375]
118005105  TUBB4A; tubulin beta-4A chain [KO:K07375]
118027362  TUBB; tubulin beta chain [KO:K07375]
118027399  tubulin beta-2A chain-like [KO:K07375]
118027402  TUBB2B; tubulin beta-2B chain [KO:K07375]
118024924  TUBG1; tubulin gamma-1 chain [KO:K10389]
118024927  tubulin gamma-2 chain isoform X1 [KO:K10389]
118024674  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
118001617  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
118008426  KIF5A; kinesin heavy chain [KO:K10396]
118012462  KIF5C; kinesin heavy chain [KO:K10396]
117998425  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
118001187  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
118016083  KLC2; kinesin light chain 2 [KO:K10407]
118002576  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
117998137  KLC3; kinesin light chain 3 [KO:K10407]
118016623  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
118011336  KIF3B; kinesin-like protein KIF3B [KO:K20196]
118014493  KIFAP3; kinesin-associated protein 3 [KO:K25388]
118007667  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
118019635  KIF17; kinesin-like protein KIF17 [KO:K20198]
117999950  KIF1C; kinesin-like protein KIF1C isoform X1 [KO:K10392]
118011873  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
118020018  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
118022129  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
117997444  KIF13A; kinesin-like protein KIF13A [KO:K17914]
118014228  KIF14; kinesin-like protein KIF14 [KO:K17915]
118011218  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
118003029  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
118026008  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
118023048  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
118025512  KIF21A; kinesin-like protein KIF21A [KO:K24185]
118014223  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
118023311  KIF27; kinesin-like protein KIF27 [KO:K24186]
118023750  KIF11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
118023531  KIF20B; kinesin-like protein KIF20B [KO:K10402]
118016678  KIF20A; kinesin-like protein KIF20A [KO:K10402]
118002974  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
118026993  centromere-associated protein E-like [KO:K11498]
118015717  KIF18A; kinesin-like protein KIF18A [KO:K10401]
118024989  KIF18B; kinesin-like protein KIF18B [KO:K26156]
118024306  KIF19; kinesin-like protein KIF19 [KO:K26157]
118001224  KIF6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
118005369  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
117999614  KIF22; kinesin-like protein KIF22 [KO:K10403]
118002162  KIF26A; kinesin-like protein KIF26A [KO:K10404]
118014565  KIF26B; kinesin-like protein KIF26B [KO:K10404]
118018131  KIF12; kinesin-like protein KIF12 [KO:K10399]
118005840  KIF15; kinesin-like protein KIF15 [KO:K10400]
118016823  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
118025039  KIF2B; kinesin-like protein KIF2B [KO:K10393]
118018010  KIF24; kinesin-like protein KIF24 [KO:K10393]
118019505  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
118000580  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
118015322  KIFC2; kinesin-like protein KIFC2 [KO:K10406]
118023737  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
118001769  kinesin-like protein KIF25 [KO:K18627]
118001895  kinesin-like protein KIF25 [KO:K18627]
118008686  MYO1A; unconventional myosin-Ia [KO:K10356]
118024508  MYO1G; unconventional myosin-Ig [KO:K10356]
118025222  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
118025333  MYO1D; unconventional myosin-Id [KO:K10356]
118003640  MYO1E; unconventional myosin-Ie [KO:K10356]
118018581  MYO1H; unconventional myosin-Ih [KO:K10356]
118012201  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
118005878  MYO1F; unconventional myosin-If [KO:K10356]
118026579  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
118012682  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
118003348  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
118003743  MYO5C; unconventional myosin-Vc [KO:K10357]
118004445  MYO5B; unconventional myosin-Vb [KO:K10357]
118001260  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
118004053  MYO7A; LOW QUALITY PROTEIN: unconventional myosin-VIIa [KO:K10359]
118011699  MYO7B; unconventional myosin-VIIb [KO:K21868]
118002989  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
118005823  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
118006158  MYO10; unconventional myosin-X [KO:K12559]
118000143  MYO15A; unconventional myosin-XV [KO:K10361]
118024412  MYO15B; LOW QUALITY PROTEIN: myosin XVB [KO:K10361]
118009630  MYO16; unconventional myosin-XVI [KO:K17481]
118025266  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
118018604  MYO18B; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
118024658  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
118000070  myosin-8 [KO:K24220]
118000071  myosin-3 [KO:K24220]
118000073  myosin-2-like [KO:K24220]
118001007  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
118011406  MYH7B; myosin-7B isoform X1 [KO:K24220]
117999904  MYH13; LOW QUALITY PROTEIN: myosin-13 [KO:K24220]
117999905  myosin-1-like [KO:K24220]
118003495  myosin-7-like [KO:K17751]
118000061  MYH10; myosin-10 [KO:K10352]
117998259  MYH14; myosin-14 isoform X1 [KO:K10352]
117998736  MYH9; myosin-9 [KO:K10352]
118021860  MYH11; myosin-11 isoform X1 [KO:K10352]
118012087  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
118005172  MYL3; myosin light chain 3 [KO:K12749]
118027183  MYL4; myosin light chain 4 [KO:K12750]
118008720  MYL6B; myosin light chain 6B [KO:K12751]
118008722  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
118018471  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
118010819  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
118024560  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
118011444  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
117999242  MYL10; myosin regulatory light chain 10 [KO:K12756]
118024266  myosin regulatory light chain 12A-like [KO:K12757]
118004378  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
118004379  myosin regulatory light chain 12B [KO:K12757]
117999604  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
118012883  ACTA1; actin, alpha skeletal muscle [KO:K10354]
118012959  ACTA2; actin, aortic smooth muscle [KO:K12313]
118003185  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
118007966  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
118024176  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117999316  ACTB; actin, cytoplasmic 1 [KO:K05692]
118005799  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
118014215  TNNI1; troponin I, slow skeletal muscle isoform X1 [KO:K10371]
118011154  TNNC2; troponin C, skeletal muscle [KO:K12042]
118016196  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
118016191  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
117997899  TNNI3; troponin I, cardiac muscle [KO:K12044]
118014217  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
118017970  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
118004404  tropomyosin alpha-3 chain-like [KO:K09290]
118013841  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
118006002  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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